hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02105
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CEP250 | Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2) | UniProt NCBI |
| CNTRL | Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) | UniProt NCBI |
| TSGA10 | Testis-specific gene 10 protein (Testis development protein NYD-SP7) | UniProt NCBI |
| FAM167A | Protein FAM167A | UniProt NCBI |
| CDC42BPG | Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-380259 | 0.0295837500362 | 0.4 | CNTRL CEP250 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.0295837500362 | 0.4 | CNTRL CEP250 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8854518 | 0.0323002764482 | 0.4 | CNTRL CEP250 | AURKA Activation by TPX2 |
| REAC:R-HSA-380287 | 0.0411580285567 | 0.4 | CNTRL CEP250 | Centrosome maturation |
| REAC:R-HSA-380270 | 0.0411580285567 | 0.4 | CNTRL CEP250 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-2565942 | 0.0465369402216 | 0.4 | CNTRL CEP250 | Regulation of PLK1 Activity at G2/M Transition |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TSGA10 | FAM167A | 0.338 | 0.528 | bioplex (FAM167A) bioplex_WMM |
| CNTRL | FAM167A | 0.26 | 0.482 | bioplex (FAM167A) bioplex_WMM |
| FAM167A | CDC42BPG | 0.121 | 0.392 | bioplex (FAM167A) bioplex_WMM |
| CEP250 | FAM167A | 0.058 | 0.325 | bioplex (FAM167A) bioplex_WMM |
| TSGA10 | CNTRL | 0.008 | 0.091 | bioplex_WMM WMM_only |
| TSGA10 | CDC42BPG | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CNTRL | CDC42BPG | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CEP250 | TSGA10 | 0.008 | 0.08 | bioplex_WMM WMM_only |
| CEP250 | CNTRL | 0.008 | 0.048 | bioplex_WMM WMM_only |
| CEP250 | CDC42BPG | 0.008 | 0.048 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02105 has an average edge precision of 0.217 which is ranked 5908 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CEP250 | HuMAP2_01390 HuMAP2_02105 HuMAP2_06963 |
| CNTRL | HuMAP2_02105 HuMAP2_05551 |
| TSGA10 | HuMAP2_02105 HuMAP2_05551 |
| FAM167A | HuMAP2_02105 HuMAP2_05551 |
| CDC42BPG | HuMAP2_02105 HuMAP2_05551 |