hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02111
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AP2S1 | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin) | UniProt NCBI |
| SPC25 | Kinetochore protein Spc25 (hSpc25) | UniProt NCBI |
| ITSN1 | Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) | UniProt NCBI |
| EPS15L1 | Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) | UniProt NCBI |
| CCDC32 | Coiled-coil domain-containing protein 32 | UniProt NCBI |
| EPS15 | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856825 | 2.90272483296e-06 | 0.666666666667 | AP2S1 ITSN1 EPS15 EPS15L1 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-8856828 | 1.30320445382e-05 | 0.666666666667 | AP2S1 ITSN1 EPS15 EPS15L1 | Clathrin-mediated endocytosis |
| WP:WP437 | 0.000981982556245 | 0.5 | AP2S1 EPS15 EPS15L1 | EGF/EGFR Signaling Pathway |
| KEGG:04144 | 0.00329433483006 | 0.5 | AP2S1 EPS15 EPS15L1 | Endocytosis |
| REAC:R-HSA-199991 | 0.00529378407845 | 0.666666666667 | AP2S1 ITSN1 EPS15 EPS15L1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.00654030934977 | 0.666666666667 | AP2S1 ITSN1 EPS15 EPS15L1 | Vesicle-mediated transport |
| REAC:R-HSA-182971 | 0.00662414399653 | 0.333333333333 | EPS15L1 EPS15 | EGFR downregulation |
| GO:0005905 | 0.00986527098502 | 0.5 | AP2S1 EPS15 ITSN1 | clathrin-coated pit |
| REAC:R-HSA-177929 | 0.019874448248 | 0.333333333333 | EPS15L1 EPS15 | Signaling by EGFR |
| REAC:R-HSA-162582 | 0.0348492364063 | 0.833333333333 | AP2S1 ITSN1 SPC25 EPS15 EPS15L1 | Signal Transduction |
| CORUM:3231 | 0.0499726005494 | 0.166666666667 | EPS15 | Eps15-stonin2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CCDC32 | AP2S1 | 0.987 | 0.901 | bioplex (AP2S1) bioplex_WMM |
| EPS15 | AP2S1 | 0.483 | 0.613 | hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM gupta_WMM |
| EPS15 | SPC25 | 0.326 | 0.515 | bioplex (SPC25) bioplex_WMM gupta_WMM |
| ITSN1 | AP2S1 | 0.154 | 0.414 | bioplex (AP2S1) bioplex_WMM youn_WMM gupta_WMM |
| SPC25 | EPS15L1 | 0.115 | 0.385 | bioplex (SPC25) bioplex_WMM gupta_WMM |
| AP2S1 | EPS15L1 | 0.102 | 0.365 | bioplex (AP2S1) bioplex_WMM youn_WMM gupta_WMM |
| EPS15 | EPS15L1 | 0.027 | 0.228 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| ITSN1 | CCDC32 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| EPS15 | CCDC32 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| ITSN1 | SPC25 | 0.007 | 0.0 | gupta_WMM WMM_only |
| CCDC32 | EPS15L1 | 0.0 | 0.009 | bioplex_WMM fraction |
| EPS15 | ITSN1 | 0.0 | 0.009 | bioplex_WMM youn_WMM gupta_WMM fraction |
| ITSN1 | EPS15L1 | 0.0 | 0.003 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_02111 has an average edge precision of 0.273 which is ranked 4982 out of all 6965 complexes.
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