hu.MAP 2.0: Complex View

Genename	Protein Name	Links
FTH1	Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed]	UniProt NCBI
NCOA4	Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ret-activating protein ELE1)	UniProt NCBI
SDR16C5	Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5)	UniProt NCBI
FTL	Ferritin light chain (Ferritin L subunit)	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4313	1.9001116486e-06	0.75	FTH1 NCOA4 FTL	Ferroptosis
KEGG:04216	2.26605907722e-06	0.75	FTH1 NCOA4 FTL	Ferroptosis
CORUM:6135	5.02777038712e-06	0.5	FTH1 FTL	Ferritin complex
GO:0044754	2.03382379613e-05	0.75	FTH1 NCOA4 FTL	autolysosome
GO:0005767	7.98841194917e-05	0.75	FTH1 NCOA4 FTL	secondary lysosome
REAC:R-HSA-3000480	0.00136571756437	0.5	FTH1 FTL	Scavenging by Class A Receptors
KEGG:04978	0.00206562690353	0.5	FTH1 FTL	Mineral absorption
GO:0070288	0.00270494046827	0.5	FTH1 FTL	ferritin complex
GO:0008043	0.00270494046827	0.5	FTH1 FTL	intracellular ferritin complex
HP:0003281	0.00347280043641	0.5	FTH1 FTL	Increased serum ferritin
HP:0040133	0.0038810174634	0.5	FTH1 FTL	Abnormal serum ferritin
REAC:R-HSA-2173782	0.00596538345738	0.5	FTH1 FTL	Binding and Uptake of Ligands by Scavenger Receptors
WP:WP2884	0.0101571058973	0.5	FTH1 FTL	NRF2 pathway
REAC:R-HSA-432722	0.0143225711665	0.5	FTH1 FTL	Golgi Associated Vesicle Biogenesis
REAC:R-HSA-917937	0.0143225711665	0.5	FTH1 FTL	Iron uptake and transport
GO:0005776	0.0143823911437	0.75	FTH1 NCOA4 FTL	autophagosome
GO:0006880	0.0162267366884	0.5	FTH1 FTL	intracellular sequestering of iron ion
KEGG:04217	0.0226863463099	0.5	FTH1 FTL	Necroptosis
REAC:R-HSA-199992	0.0255411590024	0.5	FTH1 FTL	trans-Golgi Network Vesicle Budding
GO:0097577	0.0270421395626	0.5	FTH1 FTL	sequestering of iron ion
GO:0008199	0.0405595771497	0.5	FTH1 FTL	ferric iron binding

Protein 1	Protein 2	Score	Precision	Evidence
FTL	FTH1	0.176	0.435	bioplex (FTH1) bioplex_WMM
NCOA4	FTH1	0.132	0.404	bioplex (FTH1,NCOA4) bioplex_WMM
FTH1	SDR16C5	0.028	0.228	bioplex (FTH1) bioplex_WMM
NCOA4	FTL	0.021	0.185	bioplex (NCOA4) bioplex_WMM
NCOA4	SDR16C5	0.008	0.04	bioplex_WMM WMM_only
FTL	SDR16C5	0.007	0.003	bioplex_WMM WMM_only

Click to enlarge

Complex HuMAP2_02114 has an average edge precision of 0.216 which is ranked 5935 out of all 6965 complexes.