hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02124
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SF3B3 | Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130) | UniProt NCBI |
| SF3B1 | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | UniProt NCBI |
| SF3B2 | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | UniProt NCBI |
| SF3B5 | Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1737 | 3.17414367033e-12 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | SF3b complex |
| CORUM:430 | 4.81835009157e-10 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | 18S U11/U12 snRNP |
| CORUM:2755 | 1.63060294836e-09 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | 17S U2 snRNP |
| REAC:R-HSA-72165 | 2.455200129e-08 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | mRNA Splicing - Minor Pathway |
| WP:WP411 | 1.46848778508e-07 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | mRNA Processing |
| KEGG:03040 | 2.052638918e-07 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | Spliceosome |
| GO:0005689 | 3.08603851103e-07 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | U12-type spliceosomal complex |
| REAC:R-HSA-72163 | 3.66683425084e-06 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 4.37825325788e-06 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | mRNA Splicing |
| GO:0071005 | 5.61829777936e-06 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | U2-type precatalytic spliceosome |
| GO:0071011 | 6.09645078186e-06 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | precatalytic spliceosome |
| REAC:R-HSA-72203 | 1.12324610099e-05 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | Processing of Capped Intron-Containing Pre-mRNA |
| CORUM:1181 | 5.11748339077e-05 | 0.75 | SF3B1 SF3B3 SF3B2 | C complex spliceosome |
| GO:0005684 | 6.52012849586e-05 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | U2-type spliceosomal complex |
| GO:0005686 | 0.000296207880886 | 0.75 | SF3B1 SF3B5 SF3B2 | U2 snRNP |
| CORUM:351 | 0.000300134552669 | 0.75 | SF3B1 SF3B3 SF3B2 | Spliceosome |
| GO:0005681 | 0.000657808747052 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | spliceosomal complex |
| REAC:R-HSA-8953854 | 0.000676603019954 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | Metabolism of RNA |
| CORUM:1183 | 0.00203634341963 | 0.5 | SF3B1 SF3B2 | CDC5L complex |
| GO:0000398 | 0.00944788787297 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | mRNA splicing, via spliceosome |
| GO:0000377 | 0.00944788787297 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.00981835447646 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | RNA splicing, via transesterification reactions |
| GO:0097525 | 0.0106004966657 | 0.75 | SF3B1 SF3B5 SF3B2 | spliceosomal snRNP complex |
| GO:0030532 | 0.0143823911437 | 0.75 | SF3B1 SF3B5 SF3B2 | small nuclear ribonucleoprotein complex |
| GO:0008380 | 0.0187431053955 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | RNA splicing |
| GO:0120114 | 0.023464682987 | 0.75 | SF3B1 SF3B5 SF3B2 | Sm-like protein family complex |
| GO:0006397 | 0.0251226492241 | 1.0 | SF3B1 SF3B5 SF3B3 SF3B2 | mRNA processing |
| GO:0071013 | 0.03324351702 | 0.75 | SF3B1 SF3B3 SF3B2 | catalytic step 2 spliceosome |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SF3B1 | SF3B5 | 1.0 | 0.949 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SF3B3 | SF3B2 | 1.0 | 0.949 | bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SF3B1 | SF3B3 | 1.0 | 0.949 | bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SF3B3 | SF3B5 | 1.0 | 0.949 | bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| SF3B1 | SF3B2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SF3B2 | SF3B5 | 0.998 | 0.938 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_02124 has an average edge precision of 0.947 which is ranked 359 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SF3B3 | HuMAP2_02124 HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |
| SF3B1 | HuMAP2_02124 HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |
| SF3B2 | HuMAP2_02124 HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |
| SF3B5 | HuMAP2_02124 HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |