hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02128
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUP58 | Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1) | UniProt NCBI |
| EEA1 | Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2) | UniProt NCBI |
| NUP62CL | Nucleoporin-62 C-terminal-like protein | UniProt NCBI |
| NUP62 | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | UniProt NCBI |
| NUP54 | Nucleoporin p54 (54 kDa nucleoporin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03013 | 0.000498609547209 | 0.6 | NUP58 NUP62 NUP54 | RNA transport |
| GO:0017056 | 0.00139593056214 | 0.6 | NUP58 NUP62 NUP54 | structural constituent of nuclear pore |
| GO:0006409 | 0.0049400991777 | 0.6 | NUP58 NUP62 NUP54 | tRNA export from nucleus |
| GO:0071431 | 0.0049400991777 | 0.6 | NUP58 NUP62 NUP54 | tRNA-containing ribonucleoprotein complex export from nucleus |
| REAC:R-HSA-168271 | 0.00508433997358 | 0.4 | NUP62 NUP54 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-170822 | 0.00508433997358 | 0.4 | NUP62 NUP54 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-168274 | 0.00508433997358 | 0.4 | NUP62 NUP54 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-5619107 | 0.00508433997358 | 0.4 | NUP62 NUP54 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168333 | 0.00508433997358 | 0.4 | NUP62 NUP54 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-180746 | 0.00584945327803 | 0.4 | NUP62 NUP54 | Nuclear import of Rev protein |
| REAC:R-HSA-180910 | 0.00584945327803 | 0.4 | NUP62 NUP54 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-159227 | 0.00584945327803 | 0.4 | NUP62 NUP54 | Transport of the SLBP independent Mature mRNA |
| GO:0051031 | 0.005924931483 | 0.6 | NUP58 NUP62 NUP54 | tRNA transport |
| REAC:R-HSA-159230 | 0.00625202329777 | 0.4 | NUP62 NUP54 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-165054 | 0.00625202329777 | 0.4 | NUP62 NUP54 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-4085377 | 0.00625202329777 | 0.4 | NUP62 NUP54 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-3301854 | 0.00666792835349 | 0.4 | NUP62 NUP54 | Nuclear Pore Complex (NPC) Disassembly |
| GO:0097064 | 0.00703245670927 | 0.6 | NUP58 NUP62 NUP54 | ncRNA export from nucleus |
| REAC:R-HSA-177243 | 0.00709716303977 | 0.4 | NUP62 NUP54 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-176033 | 0.00709716303977 | 0.4 | NUP62 NUP54 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-3232142 | 0.0075397219523 | 0.4 | NUP62 NUP54 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 0.00894729002053 | 0.4 | NUP62 NUP54 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 0.00894729002053 | 0.4 | NUP62 NUP54 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-168253 | 0.00944309181669 | 0.4 | NUP62 NUP54 | Host Interactions with Influenza Factors |
| REAC:R-HSA-159234 | 0.00944309181669 | 0.4 | NUP62 NUP54 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 0.0104745816743 | 0.4 | NUP62 NUP54 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 0.0115592172394 | 0.4 | NUP62 NUP54 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 0.0115592172394 | 0.4 | NUP62 NUP54 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 0.0132857243802 | 0.4 | NUP62 NUP54 | Nuclear Envelope Breakdown |
| GO:0019058 | 0.0151765771023 | 0.8 | EEA1 NUP62 NUP54 NUP58 | viral life cycle |
| REAC:R-HSA-194441 | 0.0164283536306 | 0.4 | NUP62 NUP54 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 0.0164283536306 | 0.4 | NUP62 NUP54 | snRNP Assembly |
| REAC:R-HSA-6784531 | 0.019180674733 | 0.4 | NUP62 NUP54 | tRNA processing in the nucleus |
| GO:0075733 | 0.022411068229 | 0.6 | NUP58 NUP62 NUP54 | intracellular transport of virus |
| GO:0046794 | 0.0264291737868 | 0.6 | NUP58 NUP62 NUP54 | transport of virus |
| REAC:R-HSA-4551638 | 0.0278384291304 | 0.4 | NUP62 NUP54 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3371453 | 0.0278384291304 | 0.4 | NUP62 NUP54 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 0.0287045163353 | 0.4 | NUP62 NUP54 | Glycolysis |
| REAC:R-HSA-1169408 | 0.0295837500362 | 0.4 | NUP62 NUP54 | ISG15 antiviral mechanism |
| REAC:R-HSA-159236 | 0.0304761248659 | 0.4 | NUP62 NUP54 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 0.0332320424718 | 0.4 | NUP62 NUP54 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.0361060371214 | 0.4 | NUP62 NUP54 | Antiviral mechanism by IFN-stimulated genes |
| GO:0006110 | 0.0376065209581 | 0.6 | NUP58 NUP62 NUP54 | regulation of glycolytic process |
| REAC:R-HSA-72202 | 0.0390979640759 | 0.4 | NUP62 NUP54 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-5619102 | 0.0422076786847 | 0.4 | NUP62 NUP54 | SLC transporter disorders |
| REAC:R-HSA-70326 | 0.0443461879505 | 0.4 | NUP62 NUP54 | Glucose metabolism |
| GO:0016925 | 0.0472676873043 | 0.6 | NUP58 NUP62 NUP54 | protein sumoylation |
| GO:0044766 | 0.0472676873043 | 0.6 | NUP58 NUP62 NUP54 | multi-organism transport |
| GO:1902579 | 0.0472676873043 | 0.6 | NUP58 NUP62 NUP54 | multi-organism localization |
| GO:0043470 | 0.0472676873043 | 0.6 | NUP58 NUP62 NUP54 | regulation of carbohydrate catabolic process |
| REAC:R-HSA-3371556 | 0.0476518941102 | 0.4 | NUP62 NUP54 | Cellular response to heat stress |
| CORUM:2572 | 0.0499494897235 | 0.2 | EEA1 | RAB5-EEA1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NUP54 | NUP58 | 1.0 | 0.949 | hein_WMM bioplex (NUP54,NUP58) bioplex_WMM youn_WMM hein (NUP58) gupta_WMM fraction treiber_WMM |
| NUP58 | NUP62CL | 0.755 | 0.747 | bioplex (NUP58) bioplex_WMM |
| NUP54 | NUP62 | 0.601 | 0.671 | hein_WMM bioplex (NUP54) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| NUP58 | NUP62 | 0.348 | 0.535 | hein_WMM bioplex (NUP58) bioplex_WMM youn_WMM hein (NUP58) gupta_WMM fraction treiber_WMM |
| NUP54 | NUP62CL | 0.106 | 0.373 | bioplex (NUP54) bioplex_WMM |
| NUP58 | EEA1 | 0.061 | 0.337 | bioplex (NUP58) bioplex_WMM |
| NUP62CL | NUP62 | 0.009 | 0.1 | bioplex_WMM WMM_only |
| NUP54 | EEA1 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| NUP62CL | EEA1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| EEA1 | NUP62 | 0.007 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02128 has an average edge precision of 0.373 which is ranked 3601 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NUP58 | HuMAP2_01098 HuMAP2_02128 HuMAP2_05690 |
| EEA1 | HuMAP2_01618 HuMAP2_01839 HuMAP2_02128 HuMAP2_04169 |
| NUP62CL | HuMAP2_01098 HuMAP2_02128 |
| NUP62 | HuMAP2_01628 HuMAP2_02128 HuMAP2_02354 HuMAP2_05690 HuMAP2_06331 |
| NUP54 | HuMAP2_01098 HuMAP2_01628 HuMAP2_02128 |