hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02131
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SIAH1 | E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a) | UniProt NCBI |
| SIAH2 | E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2359 | 0.000799186956535 | 1.0 | SIAH2 SIAH1 | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-373752 | 0.00165916422775 | 1.0 | SIAH2 SIAH1 | Netrin-1 signaling |
| GO:1902841 | 0.00270494046827 | 1.0 | SIAH2 SIAH1 | regulation of netrin-activated signaling pathway |
| GO:1902842 | 0.00270494046827 | 1.0 | SIAH2 SIAH1 | negative regulation of netrin-activated signaling pathway |
| GO:0038007 | 0.00676235117068 | 1.0 | SIAH2 SIAH1 | netrin-activated signaling pathway |
| REAC:R-HSA-977225 | 0.00846341348499 | 1.0 | SIAH2 SIAH1 | Amyloid fiber formation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SIAH2 | SIAH1 | 0.995 | 0.923 | bioplex (SIAH1) bioplex_WMM |
Images
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Complex HuMAP2_02131 has an average edge precision of 0.923 which is ranked 461 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SIAH1 | HuMAP2_02131 HuMAP2_05978 |
| SIAH2 | HuMAP2_02131 HuMAP2_05978 |