hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02132
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1-gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I gamma) (PIP5KIgamma) | UniProt NCBI |
| PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00562 | 0.000362555397177 | 1.0 | PIP5K1A PIP5K1C | Inositol phosphate metabolism |
| KEGG:04666 | 0.000558495798951 | 1.0 | PIP5K1A PIP5K1C | Fc gamma R-mediated phagocytosis |
| KEGG:05231 | 0.000571334782835 | 1.0 | PIP5K1A PIP5K1C | Choline metabolism in cancer |
| KEGG:04070 | 0.000610727119751 | 1.0 | PIP5K1A PIP5K1C | Phosphatidylinositol signaling system |
| KEGG:05135 | 0.000906899134346 | 1.0 | PIP5K1A PIP5K1C | Yersinia infection |
| KEGG:04072 | 0.00114894316007 | 1.0 | PIP5K1A PIP5K1C | Phospholipase D signaling pathway |
| WP:WP23 | 0.00142624133782 | 1.0 | PIP5K1A PIP5K1C | B Cell Receptor Signaling Pathway |
| REAC:R-HSA-1660499 | 0.00189044166556 | 1.0 | PIP5K1A PIP5K1C | Synthesis of PIPs at the plasma membrane |
| KEGG:04810 | 0.00253730419006 | 1.0 | PIP5K1A PIP5K1C | Regulation of actin cytoskeleton |
| WP:WP51 | 0.00322133819403 | 1.0 | PIP5K1A PIP5K1C | Regulation of Actin Cytoskeleton |
| KEGG:04144 | 0.00387576825996 | 1.0 | PIP5K1A PIP5K1C | Endocytosis |
| REAC:R-HSA-6811558 | 0.00393171644273 | 1.0 | PIP5K1A PIP5K1C | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.00477638186777 | 1.0 | PIP5K1A PIP5K1C | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-1483255 | 0.00503279815751 | 1.0 | PIP5K1A PIP5K1C | PI Metabolism |
| GO:0016308 | 0.00676235117068 | 1.0 | PIP5K1A PIP5K1C | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| REAC:R-HSA-1483257 | 0.0282158474125 | 1.0 | PIP5K1A PIP5K1C | Phospholipid metabolism |
| GO:0016307 | 0.0351642260875 | 1.0 | PIP5K1A PIP5K1C | phosphatidylinositol phosphate kinase activity |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | PIP5K1A PIP5K1C | PIP3 activates AKT signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PIP5K1A | PIP5K1C | 0.992 | 0.912 | bioplex (PIP5K1A) bioplex_WMM |
Images
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Complex HuMAP2_02132 has an average edge precision of 0.912 which is ranked 502 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PIP5K1C | HuMAP2_02132 HuMAP2_04983 HuMAP2_06505 |
| PIP5K1A | HuMAP2_02132 HuMAP2_04983 HuMAP2_06505 |