hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02137

Confidence: Medium

Genename	Protein Name	Links
UTP4	U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component)	UniProt NCBI
NOL7	Nucleolar protein 7 (Nucleolar protein of 27 kDa)	UniProt NCBI
HEATR1	HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed]	UniProt NCBI
WDR43	WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog)	UniProt NCBI
IPO13	Importin-13 (Imp13) (Karyopherin-13) (Kap13) (Ran-binding protein 13) (RanBP13)	UniProt NCBI
MON2	Protein MON2 homolog (Protein SF21)	UniProt NCBI
WDR75	WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)	UniProt NCBI
CNRIP1	CB1 cannabinoid receptor-interacting protein 1 (CRIP-1)	UniProt NCBI
NOL11	Nucleolar protein 11	UniProt NCBI
UTP15	U3 small nucleolar RNA-associated protein 15 homolog	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-6790901	1.43419579799e-10	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	rRNA modification in the nucleus and cytosol
KEGG:03008	3.84348276176e-08	0.5	HEATR1 UTP15 WDR43 WDR75 UTP4	Ribosome biogenesis in eukaryotes
GO:0045943	4.18200118726e-08	0.5	UTP15 NOL11 WDR43 WDR75 HEATR1	positive regulation of transcription by RNA polymerase I
REAC:R-HSA-6791226	1.25107582264e-07	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	Major pathway of rRNA processing in the nucleolus and cytosol
REAC:R-HSA-8868773	1.73111022823e-07	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	rRNA processing in the nucleus and cytosol
REAC:R-HSA-72312	2.35515548217e-07	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	rRNA processing
GO:0006356	2.43511577028e-07	0.5	UTP15 NOL11 WDR43 WDR75 HEATR1	regulation of transcription by RNA polymerase I
GO:2000234	6.4446669519e-07	0.4	UTP15 WDR43 WDR75 HEATR1	positive regulation of rRNA processing
GO:0090070	6.4446669519e-07	0.4	UTP15 WDR43 WDR75 HEATR1	positive regulation of ribosome biogenesis
GO:2000232	2.52938509427e-06	0.4	UTP15 WDR43 WDR75 HEATR1	regulation of rRNA processing
GO:0090069	3.65237807149e-06	0.4	UTP15 WDR43 WDR75 HEATR1	regulation of ribosome biogenesis
GO:0006360	1.01797815181e-05	0.5	UTP15 NOL11 WDR43 WDR75 HEATR1	transcription by RNA polymerase I
GO:0034455	1.08982291228e-05	0.3	UTP4 NOL11 HEATR1	t-UTP complex
GO:0006364	2.27506958544e-05	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	rRNA processing
GO:0016072	3.09128661745e-05	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	rRNA metabolic process
GO:0042254	0.000144204297775	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	ribosome biogenesis
REAC:R-HSA-8953854	0.000259932734672	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	Metabolism of RNA
GO:0034470	0.00083455006321	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	ncRNA processing
GO:0044452	0.00195027484661	0.5	HEATR1 UTP15 WDR43 NOL11 UTP4	nucleolar part
GO:0022613	0.00217923587035	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	ribonucleoprotein complex biogenesis
GO:0034660	0.00351697198321	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	ncRNA metabolic process
GO:0005730	0.00415706884416	0.7	HEATR1 WDR75 UTP15 UTP4 WDR43 NOL7 NOL11	nucleolus
MIRNA:hsa-miR-16-5p	0.0449959292106	0.6	HEATR1 NOL11 UTP15 WDR43 UTP4 WDR75	hsa-miR-16-5p
GO:0001650	0.0462322956675	0.4	HEATR1 UTP15 WDR43 UTP4	fibrillar center

Edges

Protein 1	Protein 2	Score	Precision	Evidence
UTP4	NOL11	0.916	0.839	bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
UTP4	WDR43	0.798	0.764	hein_WMM bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
UTP4	CNRIP1	0.648	0.686	bioplex (CNRIP1) bioplex_WMM
UTP15	UTP4	0.57	0.656	hein_WMM bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
UTP15	NOL11	0.428	0.576	bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM
UTP4	WDR75	0.398	0.559	bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
HEATR1	UTP15	0.237	0.47	bioplex_WMM youn_WMM Malo gupta_WMM fraction
UTP15	NOL7	0.06	0.336	bioplex (NOL7) bioplex_WMM youn_WMM treiber_WMM
WDR75	NOL7	0.048	0.295	bioplex (NOL7) bioplex_WMM youn_WMM
HEATR1	IPO13	0.026	0.218	bioplex_WMM boldt youn_WMM boldt_WMM
IPO13	MON2	0.023	0.211	bioplex_WMM boldt boldt_WMM
NOL7	WDR43	0.023	0.211	bioplex (NOL7) bioplex_WMM youn_WMM
UTP15	WDR43	0.015	0.152	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
WDR75	WDR43	0.015	0.144	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
UTP15	WDR75	0.013	0.151	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
WDR43	NOL11	0.01	0.122	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
WDR75	NOL11	0.009	0.101	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
NOL7	NOL11	0.008	0.068	bioplex (NOL7) bioplex_WMM youn_WMM
HEATR1	UTP4	0.008	0.024	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
HEATR1	WDR43	0.007	0.014	youn_WMM gupta_WMM WMM_only treiber_WMM
HEATR1	NOL7	0.007	0.003	bioplex_WMM youn_WMM WMM_only boldt_WMM
HEATR1	NOL11	0.007	0.008	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
NOL7	MON2	0.007	0.004	bioplex_WMM youn_WMM WMM_only
UTP15	MON2	0.007	0.0	bioplex_WMM youn_WMM WMM_only
NOL7	IPO13	0.007	0.004	bioplex_WMM WMM_only
WDR43	MON2	0.007	0.0	youn_WMM gupta_WMM WMM_only
WDR75	MON2	0.007	0.001	youn_WMM WMM_only
UTP4	MON2	0.007	0.001	bioplex_WMM youn_WMM WMM_only
UTP15	IPO13	0.007	0.001	bioplex_WMM WMM_only
NOL7	CNRIP1	0.007	0.005	bioplex_WMM WMM_only
NOL11	IPO13	0.007	0.005	bioplex_WMM WMM_only
NOL11	MON2	0.007	0.001	bioplex_WMM youn_WMM WMM_only
UTP4	NOL7	0.006	0.004	bioplex (NOL7,UTP4) bioplex_WMM youn_WMM treiber_WMM
HEATR1	MON2	0.006	0.004	bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM
HEATR1	WDR75	0.0	0.001	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM

Images

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Complex HuMAP2_02137 has an average edge precision of 0.19 which is ranked 6314 out of all 6965 complexes.

Related Complexes

Genename	Complexes
UTP4	HuMAP2_01136 HuMAP2_02137 HuMAP2_02340 HuMAP2_03243 HuMAP2_03334 HuMAP2_03580 HuMAP2_04259 HuMAP2_06420
NOL7	HuMAP2_01136 HuMAP2_02137 HuMAP2_02340 HuMAP2_04259 HuMAP2_06420
HEATR1	HuMAP2_01080 HuMAP2_02137 HuMAP2_02340 HuMAP2_04259
WDR43	HuMAP2_01136 HuMAP2_02137 HuMAP2_03243 HuMAP2_03334 HuMAP2_03580 HuMAP2_04259
IPO13	HuMAP2_02137 HuMAP2_04259
MON2	HuMAP2_02137 HuMAP2_04259
WDR75	HuMAP2_01136 HuMAP2_02137 HuMAP2_02340 HuMAP2_03334 HuMAP2_04259 HuMAP2_06420
CNRIP1	HuMAP2_01136 HuMAP2_02137 HuMAP2_03243 HuMAP2_03334 HuMAP2_04259 HuMAP2_06420
NOL11	HuMAP2_01136 HuMAP2_02137 HuMAP2_02340 HuMAP2_03243 HuMAP2_03334 HuMAP2_03580 HuMAP2_04259 HuMAP2_06420
UTP15	HuMAP2_01136 HuMAP2_02137 HuMAP2_02340 HuMAP2_03243 HuMAP2_03334 HuMAP2_04259 HuMAP2_06420

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02137