hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02144
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUPT20H | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | UniProt NCBI |
| KAT2A | Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97) | UniProt NCBI |
| TADA3 | Transcriptional adapter 3 (ADA3 homolog) (hADA3) (STAF54) (Transcriptional adapter 3-like) (ADA3-like protein) | UniProt NCBI |
| TADA2A | Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) | UniProt NCBI |
| KAT14 | Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14) | UniProt NCBI |
| SGF29 | SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) | UniProt NCBI |
| MBIP | MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) | UniProt NCBI |
| KAT2B | Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57) | UniProt NCBI |
| YEATS2 | YEATS domain-containing protein 2 | UniProt NCBI |
| ZNF131 | Zinc finger protein 131 | UniProt NCBI |
| ZZZ3 | ZZ-type zinc finger-containing protein 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6657 | 8.37746696956e-24 | 0.727272727273 | KAT2A MBIP TADA2A SGF29 ZZZ3 KAT14 YEATS2 TADA3 | ATAC complex, GCN5-linked |
| CORUM:6665 | 5.58655726126e-22 | 0.727272727273 | KAT2A MBIP TADA2A SGF29 ZZZ3 KAT14 YEATS2 TADA3 | ATAC complex, YEATS2-linked |
| GO:0005671 | 1.75501085012e-15 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | Ada2/Gcn5/Ada3 transcription activator complex |
| REAC:R-HSA-3214847 | 5.97805620303e-15 | 0.818181818182 | KAT2A SUPT20H MBIP KAT2B SGF29 ZZZ3 KAT14 YEATS2 TADA3 | HATs acetylate histones |
| REAC:R-HSA-4839726 | 2.09223518187e-12 | 0.818181818182 | KAT2A SUPT20H MBIP KAT2B SGF29 ZZZ3 KAT14 YEATS2 TADA3 | Chromatin organization |
| REAC:R-HSA-3247509 | 2.09223518187e-12 | 0.818181818182 | KAT2A SUPT20H MBIP KAT2B SGF29 ZZZ3 KAT14 YEATS2 TADA3 | Chromatin modifying enzymes |
| GO:0000123 | 3.18660292868e-12 | 0.727272727273 | KAT2A SUPT20H MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | histone acetyltransferase complex |
| GO:1902493 | 8.71999915837e-12 | 0.727272727273 | KAT2A SUPT20H MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | acetyltransferase complex |
| GO:0031248 | 8.71999915837e-12 | 0.727272727273 | KAT2A SUPT20H MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | protein acetyltransferase complex |
| GO:1902562 | 1.14236811498e-11 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | H4 histone acetyltransferase complex |
| GO:0043966 | 5.06464425371e-11 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | histone H3 acetylation |
| GO:0016573 | 1.30451153705e-08 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | histone acetylation |
| GO:0018393 | 1.48994845416e-08 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | internal peptidyl-lysine acetylation |
| GO:0006475 | 2.05506303497e-08 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | internal protein amino acid acetylation |
| GO:0018394 | 2.18774399626e-08 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | peptidyl-lysine acetylation |
| CORUM:6664 | 3.31599626832e-08 | 0.363636363636 | KAT2A SUPT20H SGF29 TADA3 | STAGA complex, SPT3-linked |
| CORUM:6643 | 4.19868136666e-08 | 0.363636363636 | KAT2A SUPT20H SGF29 TADA3 | SAGA complex, GCN5-linked |
| GO:0006473 | 1.26156284482e-07 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | protein acetylation |
| GO:0070461 | 1.99732718129e-07 | 0.454545454545 | KAT2A KAT2B SUPT20H SGF29 TADA3 | SAGA-type complex |
| GO:0043543 | 5.73905505782e-07 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | protein acylation |
| CORUM:471 | 2.42644341986e-06 | 0.272727272727 | TADA3 TADA2A KAT2B | PCAF complex |
| CORUM:477 | 2.42644341986e-06 | 0.272727272727 | TADA3 TADA2A KAT2B | PCAF complex |
| GO:0018205 | 1.38271175108e-05 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | peptidyl-lysine modification |
| GO:0016570 | 3.38208832323e-05 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | histone modification |
| GO:0016569 | 4.63498309108e-05 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | covalent chromatin modification |
| GO:1990234 | 0.000164689157322 | 0.727272727273 | KAT2A SUPT20H MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | transferase complex |
| CORUM:0000000 | 0.000238379812555 | 0.909090909091 | KAT2A SUPT20H MBIP KAT2B SGF29 ZZZ3 TADA2A KAT14 YEATS2 TADA3 | CORUM root |
| CORUM:6641 | 0.000937200833563 | 0.181818181818 | KAT2A TADA3 | USP22-SAGA complex |
| GO:0044451 | 0.00142432637195 | 0.727272727273 | KAT2A SUPT20H MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | nucleoplasm part |
| CORUM:438 | 0.0015050021591 | 0.181818181818 | KAT2A TADA3 | GCN5-TRRAP histone acetyltransferase complex |
| GO:0006325 | 0.00193227521823 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | chromatin organization |
| CORUM:475 | 0.00220555818369 | 0.181818181818 | KAT2A TADA3 | STAGA complex |
| CORUM:476 | 0.00220555818369 | 0.181818181818 | KAT2A TADA3 | STAGA complex |
| GO:0000124 | 0.0024645761864 | 0.272727272727 | TADA3 SUPT20H SGF29 | SAGA complex |
| GO:0004402 | 0.0028995469326 | 0.363636363636 | KAT2A KAT2B KAT14 TADA3 | histone acetyltransferase activity |
| GO:0061733 | 0.00334684762898 | 0.363636363636 | KAT2A KAT2B KAT14 TADA3 | peptide-lysine-N-acetyltransferase activity |
| CORUM:445 | 0.00350460312996 | 0.181818181818 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:455 | 0.00350460312996 | 0.181818181818 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:456 | 0.00350460312996 | 0.181818181818 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:462 | 0.00350460312996 | 0.181818181818 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:513 | 0.00400364699879 | 0.181818181818 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:470 | 0.00400364699879 | 0.181818181818 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| GO:0034212 | 0.00602588334679 | 0.363636363636 | KAT2A KAT2B KAT14 TADA3 | peptide N-acetyltransferase activity |
| REAC:R-HSA-8941856 | 0.00844507994095 | 0.181818181818 | KAT2A KAT2B | RUNX3 regulates NOTCH signaling |
| REAC:R-HSA-210744 | 0.00984862364944 | 0.181818181818 | KAT2A KAT2B | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| GO:0008080 | 0.0105990723032 | 0.363636363636 | KAT2A KAT2B KAT14 TADA3 | N-acetyltransferase activity |
| GO:1902494 | 0.0111232355916 | 0.727272727273 | KAT2A SUPT20H MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | catalytic complex |
| REAC:R-HSA-9013695 | 0.0184695024726 | 0.181818181818 | KAT2A KAT2B | NOTCH4 Intracellular Domain Regulates Transcription |
| GO:0016410 | 0.0199147327968 | 0.363636363636 | KAT2A KAT2B KAT14 TADA3 | N-acyltransferase activity |
| KEGG:04330 | 0.0237135359686 | 0.181818181818 | KAT2A KAT2B | Notch signaling pathway |
| WP:WP268 | 0.0244944369611 | 0.181818181818 | KAT2A KAT2B | Notch Signaling |
| GO:0016407 | 0.0258322357025 | 0.363636363636 | KAT2A KAT2B KAT14 TADA3 | acetyltransferase activity |
| REAC:R-HSA-9013508 | 0.0272822106263 | 0.181818181818 | KAT2A KAT2B | NOTCH3 Intracellular Domain Regulates Transcription |
| GO:0018193 | 0.0316059482924 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | peptidyl-amino acid modification |
| REAC:R-HSA-350054 | 0.0377890612586 | 0.181818181818 | KAT2A KAT2B | Notch-HLH transcription pathway |
| REAC:R-HSA-186712 | 0.0436752094358 | 0.181818181818 | KAT2A KAT2B | Regulation of beta-cell development |
| GO:0051276 | 0.0471465755723 | 0.636363636364 | KAT2A MBIP KAT2B SGF29 KAT14 YEATS2 TADA3 | chromosome organization |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SGF29 | TADA3 | 1.0 | 0.949 | hein_WMM bioplex (SGF29,TADA3) bioplex_WMM Guru youn_WMM hein (SGF29) Malo fraction boldt_WMM |
| KAT14 | MBIP | 1.0 | 0.949 | bioplex (MBIP) bioplex_WMM |
| ZZZ3 | MBIP | 0.999 | 0.949 | hein_WMM bioplex (MBIP) bioplex_WMM youn_WMM |
| MBIP | YEATS2 | 0.999 | 0.949 | hein_WMM bioplex (MBIP) bioplex_WMM youn_WMM |
| SGF29 | SUPT20H | 0.994 | 0.919 | hein_WMM bioplex (SGF29) bioplex_WMM youn_WMM hein (SGF29) boldt_WMM |
| MBIP | TADA2A | 0.987 | 0.901 | hein_WMM bioplex (MBIP) bioplex_WMM |
| TADA3 | KAT14 | 0.987 | 0.901 | bioplex (TADA3) bioplex_WMM youn_WMM |
| TADA3 | KAT2B | 0.986 | 0.901 | bioplex (TADA3) bioplex_WMM |
| KAT2A | SGF29 | 0.981 | 0.897 | hein_WMM bioplex (SGF29) bioplex_WMM hein (SGF29) boldt_WMM |
| SGF29 | TADA2A | 0.972 | 0.885 | hein_WMM bioplex (SGF29) bioplex_WMM hein (SGF29) |
| SGF29 | YEATS2 | 0.969 | 0.881 | hein_WMM bioplex (SGF29) bioplex_WMM youn_WMM hein (SGF29) gupta_WMM |
| TADA3 | TADA2A | 0.963 | 0.871 | hein_WMM bioplex (TADA3) bioplex_WMM |
| KAT2A | TADA3 | 0.962 | 0.87 | hein_WMM bioplex (TADA3) bioplex_WMM boldt_WMM |
| TADA3 | MBIP | 0.946 | 0.857 | hein_WMM bioplex (MBIP,TADA3) bioplex_WMM youn_WMM |
| TADA3 | YEATS2 | 0.895 | 0.821 | hein_WMM bioplex (TADA3) bioplex_WMM youn_WMM |
| SGF29 | MBIP | 0.872 | 0.804 | hein_WMM bioplex (MBIP,SGF29) bioplex_WMM youn_WMM hein (SGF29) |
| SGF29 | ZZZ3 | 0.871 | 0.804 | hein_WMM bioplex (SGF29) bioplex_WMM youn_WMM hein (SGF29) |
| TADA3 | ZZZ3 | 0.818 | 0.773 | hein_WMM bioplex (TADA3) bioplex_WMM youn_WMM |
| SUPT20H | TADA3 | 0.742 | 0.74 | hein_WMM bioplex (TADA3) bioplex_WMM youn_WMM boldt_WMM |
| ZNF131 | MBIP | 0.588 | 0.662 | bioplex (MBIP) bioplex_WMM |
| KAT2A | MBIP | 0.585 | 0.663 | hein_WMM bioplex (MBIP) bioplex_WMM |
| MBIP | KAT2B | 0.486 | 0.615 | bioplex (MBIP) bioplex_WMM |
| SGF29 | KAT2B | 0.137 | 0.407 | bioplex (SGF29) bioplex_WMM |
| ZZZ3 | YEATS2 | 0.086 | 0.351 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| KAT14 | ZZZ3 | 0.06 | 0.336 | bioplex_WMM WMM_only |
| KAT14 | YEATS2 | 0.058 | 0.325 | bioplex_WMM youn_WMM WMM_only |
| KAT2A | KAT2B | 0.031 | 0.24 | bioplex_WMM WMM_only |
| ZZZ3 | TADA2A | 0.025 | 0.211 | hein_WMM bioplex_WMM WMM_only |
| YEATS2 | TADA2A | 0.021 | 0.194 | hein_WMM bioplex_WMM WMM_only |
| KAT2A | TADA2A | 0.021 | 0.184 | hein_WMM bioplex_WMM WMM_only |
| KAT14 | TADA2A | 0.02 | 0.185 | bioplex_WMM WMM_only |
| KAT2A | KAT14 | 0.016 | 0.157 | bioplex_WMM WMM_only |
| KAT2A | YEATS2 | 0.016 | 0.161 | hein_WMM bioplex_WMM WMM_only |
| KAT2A | ZZZ3 | 0.016 | 0.154 | hein_WMM bioplex_WMM WMM_only |
| KAT2B | TADA2A | 0.015 | 0.143 | bioplex_WMM WMM_only |
| KAT14 | KAT2B | 0.014 | 0.144 | bioplex_WMM WMM_only |
| KAT2B | YEATS2 | 0.013 | 0.151 | bioplex_WMM WMM_only |
| SUPT20H | KAT2B | 0.013 | 0.151 | bioplex_WMM WMM_only |
| KAT2A | SUPT20H | 0.013 | 0.155 | hein_WMM bioplex_WMM WMM_only boldt_WMM |
| ZZZ3 | KAT2B | 0.012 | 0.146 | bioplex_WMM WMM_only |
| SUPT20H | TADA2A | 0.009 | 0.113 | hein_WMM bioplex_WMM WMM_only |
| SUPT20H | ZZZ3 | 0.009 | 0.101 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SUPT20H | MBIP | 0.009 | 0.099 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SUPT20H | YEATS2 | 0.008 | 0.089 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ZNF131 | YEATS2 | 0.008 | 0.044 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ZNF131 | TADA3 | 0.008 | 0.039 | bioplex_WMM youn_WMM WMM_only |
| ZNF131 | TADA2A | 0.008 | 0.016 | bioplex_WMM WMM_only |
| SUPT20H | KAT14 | 0.008 | 0.024 | bioplex_WMM youn_WMM WMM_only |
| ZNF131 | SGF29 | 0.008 | 0.009 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ZNF131 | KAT2B | 0.007 | 0.006 | bioplex_WMM WMM_only |
| ZNF131 | KAT2A | 0.007 | 0.009 | bioplex_WMM WMM_only |
| ZNF131 | ZZZ3 | 0.007 | 0.005 | bioplex_WMM youn_WMM WMM_only |
| ZNF131 | KAT14 | 0.007 | 0.011 | bioplex_WMM youn_WMM WMM_only |
| ZNF131 | SUPT20H | 0.007 | 0.005 | youn_WMM WMM_only |
| SGF29 | KAT14 | 0.005 | 0.008 | bioplex (SGF29) bioplex_WMM youn_WMM |
Images
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Complex HuMAP2_02144 has an average edge precision of 0.417 which is ranked 3141 out of all 6965 complexes.
Related Complexes