hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02160

Confidence: Medium High

Genename	Protein Name	Links
LIMA1	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)	UniProt NCBI
DBN1	Drebrin (Developmentally-regulated brain protein)	UniProt NCBI
ACTG1	Actin, cytoplasmic 2 (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]	UniProt NCBI
MISP	Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein)	UniProt NCBI
MYO6	Unconventional myosin-VI (Unconventional myosin-6)	UniProt NCBI
MYO1C	Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)	UniProt NCBI
MYH9	Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)	UniProt NCBI
CALML3	Calmodulin-like protein 3 (CaM-like protein) (CLP) (Calmodulin-related protein NB-1)	UniProt NCBI
SVIL	Supervillin (Archvillin) (p205/p250)	UniProt NCBI
TMOD3	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)	UniProt NCBI
NEXN	Nexilin (F-actin-binding protein) (Nelin)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0015629	1.29389855037e-08	0.818181818182	DBN1 ACTG1 TMOD3 MYO1C MYO6 MISP MYH9 SVIL LIMA1	actin cytoskeleton
GO:0051015	9.8620702641e-08	0.636363636364	DBN1 LIMA1 MYO6 MISP MYH9 SVIL NEXN	actin filament binding
GO:0003779	7.88819254127e-06	0.636363636364	DBN1 LIMA1 MYO6 MISP MYH9 SVIL NEXN	actin binding
GO:0099512	1.59921657141e-05	0.727272727273	DBN1 ACTG1 MYO1C NEXN MYO6 MISP SVIL TMOD3	supramolecular fiber
GO:0099081	1.7517714484e-05	0.727272727273	DBN1 ACTG1 MYO1C NEXN MYO6 MISP SVIL TMOD3	supramolecular polymer
GO:0099080	1.77839322092e-05	0.727272727273	DBN1 ACTG1 MYO1C NEXN MYO6 MISP SVIL TMOD3	supramolecular complex
GO:0008092	0.000196965607555	0.727272727273	DBN1 LIMA1 NEXN MYO6 MISP MYH9 SVIL TMOD3	cytoskeletal protein binding
GO:0005884	0.000236469407566	0.454545454545	DBN1 MYO6 MYO1C ACTG1 MISP	actin filament
KEGG:05130	0.000268536654501	0.363636363636	MYO1C MYH9 ACTG1 MYO6	Pathogenic Escherichia coli infection
GO:0044430	0.000303715640978	0.818181818182	DBN1 ACTG1 TMOD3 MYO1C MYO6 MISP MYH9 SVIL LIMA1	cytoskeletal part
GO:0005912	0.00035747053878	0.636363636364	MISP LIMA1 NEXN TMOD3 MYH9 SVIL ACTG1	adherens junction
GO:0070161	0.000421723272005	0.636363636364	MISP LIMA1 NEXN TMOD3 MYH9 SVIL ACTG1	anchoring junction
GO:0005856	0.00203520096664	0.818181818182	DBN1 ACTG1 TMOD3 MYO1C MYO6 MISP MYH9 SVIL LIMA1	cytoskeleton
REAC:R-HSA-2029482	0.0020889055103	0.272727272727	MYO1C ACTG1 MYH9	Regulation of actin dynamics for phagocytic cup formation
REAC:R-HSA-1445148	0.00320858712168	0.272727272727	MYO1C ACTG1 MYH9	Translocation of SLC2A4 (GLUT4) to the plasma membrane
GO:0005925	0.00361066709088	0.545454545455	MISP LIMA1 NEXN MYH9 SVIL ACTG1	focal adhesion
GO:0005924	0.00373351226538	0.545454545455	MISP LIMA1 NEXN MYH9 SVIL ACTG1	cell-substrate adherens junction
GO:0030055	0.00405583141134	0.545454545455	MISP LIMA1 NEXN MYH9 SVIL ACTG1	cell-substrate junction
REAC:R-HSA-2029480	0.00523472188549	0.272727272727	MYO1C ACTG1 MYH9	Fcgamma receptor (FCGR) dependent phagocytosis
GO:0099513	0.00585037001196	0.545454545455	DBN1 ACTG1 MYO1C MYO6 MISP SVIL	polymeric cytoskeletal fiber
GO:0030054	0.00604791278478	0.636363636364	MISP LIMA1 NEXN TMOD3 MYH9 SVIL ACTG1	cell junction
REAC:R-HSA-190873	0.00714871709538	0.181818181818	MYO6 ACTG1	Gap junction degradation
GO:0044877	0.0140547932033	0.636363636364	DBN1 LIMA1 MYO6 MISP MYH9 SVIL NEXN	protein-containing complex binding

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SVIL	TMOD3	0.979	0.895	hein_WMM bioplex (TMOD3) bioplex_WMM youn_WMM hein (TMOD3) gupta_WMM
DBN1	LIMA1	0.831	0.778	hein_WMM bioplex_WMM youn_WMM hein (DBN1,LIMA1) gupta_WMM treiber_WMM
TMOD3	LIMA1	0.823	0.774	hein_WMM bioplex (TMOD3) bioplex_WMM youn_WMM hein (LIMA1) gupta_WMM
NEXN	LIMA1	0.422	0.573	hein_WMM bioplex (NEXN) bioplex_WMM hein (LIMA1)
TMOD3	NEXN	0.407	0.566	hein_WMM bioplex (NEXN) bioplex_WMM hein (TMOD3)
TMOD3	MYH9	0.349	0.536	hein_WMM bioplex (MYH9,TMOD3) bioplex_WMM youn_WMM hein (MYH9) gupta_WMM boldt_WMM treiber_WMM
ACTG1	MYH9	0.322	0.512	hein_WMM hein (MYH9) gupta_WMM boldt_WMM
LIMA1	ACTG1	0.27	0.483	hein_WMM hein (LIMA1) gupta_WMM
DBN1	MYO6	0.264	0.481	hein_WMM bioplex (DBN1,MYO6) bioplex_WMM youn_WMM hein (DBN1) gupta_WMM treiber_WMM
MYO1C	ACTG1	0.17	0.427	hein_WMM hein (MYO1C) boldt_WMM
DBN1	ACTG1	0.152	0.409	hein_WMM hein (DBN1) gupta_WMM boldt_WMM
DBN1	CALML3	0.15	0.41	hein_WMM bioplex_WMM hein (CALML3)
ACTG1	CALML3	0.146	0.409	hein_WMM hein (CALML3) boldt_WMM
LIMA1	CALML3	0.141	0.405	hein_WMM bioplex_WMM hein (CALML3)
TMOD3	ACTG1	0.129	0.4	hein_WMM hein (TMOD3) gupta_WMM boldt_WMM
TMOD3	MYO1C	0.124	0.397	hein_WMM bioplex (TMOD3) bioplex_WMM youn_WMM hein (MYO1C)
MYO1C	CALML3	0.112	0.38	hein_WMM bioplex_WMM hein (CALML3)
MISP	CALML3	0.107	0.372	hein_WMM hein (CALML3)
NEXN	CALML3	0.1	0.36	hein_WMM hein (CALML3)
SVIL	CALML3	0.089	0.352	hein_WMM hein (CALML3)
MYO1C	LIMA1	0.085	0.349	hein_WMM bioplex_WMM youn_WMM hein (LIMA1,MYO1C) treiber_WMM
MYO1C	DBN1	0.067	0.35	hein_WMM bioplex (DBN1) bioplex_WMM youn_WMM hein (DBN1,MYO1C) treiber_WMM
MISP	LIMA1	0.065	0.347	hein_WMM hein (LIMA1) treiber_WMM
TMOD3	MYO6	0.064	0.348	hein_WMM bioplex (MYO6,TMOD3) bioplex_WMM youn_WMM hein (TMOD3) gupta_WMM fraction
NEXN	MYH9	0.059	0.328	hein_WMM bioplex (NEXN) bioplex_WMM hein (MYH9)
MISP	MYH9	0.058	0.323	hein_WMM hein (MYH9) treiber_WMM
MISP	DBN1	0.057	0.321	hein_WMM hein (DBN1) treiber_WMM
LIMA1	MYH9	0.056	0.312	hein_WMM bioplex_WMM youn_WMM hein (MYH9) gupta_WMM treiber_WMM
TMOD3	CALML3	0.055	0.306	hein_WMM bioplex_WMM hein (CALML3)
NEXN	DBN1	0.053	0.301	hein_WMM bioplex (NEXN) hein (DBN1)
MYO1C	MISP	0.045	0.293	hein_WMM bioplex (MISP) hein (MYO1C) treiber_WMM
MYO1C	MYO6	0.043	0.269	hein_WMM bioplex (MYO6) bioplex_WMM boldt youn_WMM hein (MYO1C) boldt_WMM treiber_WMM
MYO1C	MYH9	0.043	0.269	hein_WMM bioplex_WMM boldt youn_WMM hein (MYH9,MYO1C) boldt_WMM treiber_WMM
SVIL	LIMA1	0.042	0.268	hein_WMM bioplex_WMM youn_WMM hein (LIMA1) gupta_WMM
LIMA1	MYO6	0.039	0.266	hein_WMM bioplex (MYO6) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
MYH9	CALML3	0.039	0.265	hein_WMM bioplex_WMM boldt hein (MYH9) boldt_WMM treiber_WMM
SVIL	DBN1	0.033	0.247	hein_WMM youn_WMM hein (DBN1) gupta_WMM
SVIL	MYH9	0.021	0.187	hein_WMM bioplex_WMM youn_WMM hein (MYH9) gupta_WMM treiber_WMM
SVIL	MYO1C	0.019	0.186	hein_WMM bioplex_WMM youn_WMM hein (MYO1C) boldt_WMM
MYO6	MYH9	0.01	0.117	hein_WMM bioplex (MYH9,MYO6) bioplex_WMM youn_WMM hein (MYH9) gupta_WMM treiber_WMM
MYO6	CALML3	0.007	0.006	hein_WMM bioplex_WMM hein (CALML3)
SVIL	NEXN	0.006	0.006	hein_WMM WMM_only
NEXN	MISP	0.006	0.008	hein_WMM WMM_only
NEXN	MYO6	0.006	0.008	hein_WMM bioplex (NEXN)
NEXN	ACTG1	0.006	0.008	hein_WMM WMM_only
SVIL	ACTG1	0.005	0.012	hein_WMM gupta_WMM WMM_only
MISP	MYO6	0.005	0.007	hein_WMM bioplex (MISP) treiber_WMM
ACTG1	MYO6	0.004	0.012	hein_WMM gupta_WMM WMM_only
MISP	ACTG1	0.004	0.009	hein_WMM WMM_only
SVIL	MISP	0.004	0.016	hein_WMM WMM_only
TMOD3	MISP	0.004	0.014	hein_WMM WMM_only
SVIL	MYO6	0.004	0.012	hein_WMM youn_WMM gupta_WMM WMM_only
TMOD3	DBN1	0.003	0.012	hein_WMM bioplex (DBN1,TMOD3) bioplex_WMM youn_WMM hein (DBN1,TMOD3) gupta_WMM fraction boldt_WMM
DBN1	MYH9	0.0	0.013	hein_WMM bioplex (DBN1,MYH9) bioplex_WMM youn_WMM hein (MYH9) gupta_WMM fraction boldt_WMM treiber_WMM
MYO1C	NEXN	0.0	0.01	hein_WMM bioplex (NEXN) bioplex_WMM hein (MYO1C)

Images

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Complex HuMAP2_02160 has an average edge precision of 0.286 which is ranked 4799 out of all 6965 complexes.

Related Complexes

Genename	Complexes
LIMA1	HuMAP2_01907 HuMAP2_02160 HuMAP2_02789 HuMAP2_04716 HuMAP2_06706
DBN1	HuMAP2_01907 HuMAP2_02160 HuMAP2_04716 HuMAP2_05657 HuMAP2_06706
ACTG1	HuMAP2_02160 HuMAP2_03895 HuMAP2_06706 HuMAP2_06976
MISP	HuMAP2_00566 HuMAP2_02160 HuMAP2_05297 HuMAP2_05462 HuMAP2_05657 HuMAP2_06706
MYO6	HuMAP2_02160 HuMAP2_02314 HuMAP2_05657 HuMAP2_06020 HuMAP2_06706 HuMAP2_06848
MYO1C	HuMAP2_00433 HuMAP2_01461 HuMAP2_01930 HuMAP2_02160 HuMAP2_06706
MYH9	HuMAP2_02160 HuMAP2_02178 HuMAP2_03239 HuMAP2_03956 HuMAP2_06706
CALML3	HuMAP2_02160 HuMAP2_02789 HuMAP2_05394 HuMAP2_06706
SVIL	HuMAP2_00057 HuMAP2_00088 HuMAP2_02160 HuMAP2_02789 HuMAP2_06706
TMOD3	HuMAP2_00057 HuMAP2_00088 HuMAP2_02160 HuMAP2_02314 HuMAP2_02789 HuMAP2_06706
NEXN	HuMAP2_00523 HuMAP2_02160 HuMAP2_02789 HuMAP2_06706

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02160