hu.MAP 2.0: Complex View

Genename	Protein Name	Links
MAPK1	Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)	UniProt NCBI
TET2	Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)	UniProt NCBI
PROSER1	Proline and serine-rich protein 1	UniProt NCBI
CYCS	Cytochrome c	UniProt NCBI
NONO	Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (55 kDa nuclear protein) (DNA-binding p52/p100 complex, 52 kDa subunit) (NMT55) (p54(nrb)) (p54nrb)	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9627069	0.000889652787086	0.4	CYCS MAPK1	Regulation of the apoptosome activity
REAC:R-HSA-111458	0.000889652787086	0.4	CYCS MAPK1	Formation of apoptosome
REAC:R-HSA-111461	0.00122631290825	0.4	CYCS MAPK1	Cytochrome c-mediated apoptotic response
REAC:R-HSA-111471	0.00161668141155	0.4	CYCS MAPK1	Apoptotic factor-mediated response
WP:WP2324	0.00688743357746	0.4	CYCS MAPK1	AGE/RAGE pathway
WP:WP4255	0.00799132765459	0.4	CYCS MAPK1	Non-small cell lung cancer
WP:WP4216	0.00822185347081	0.4	CYCS MAPK1	Chromosomal and microsatellite instability in colorectal cancer
WP:WP4298	0.00917640250894	0.4	CYCS MAPK1	Viral Acute Myocarditis
WP:WP2059	0.0104424923561	0.4	CYCS MAPK1	Alzheimers Disease
KEGG:01524	0.0108715181024	0.4	CYCS MAPK1	Platinum drug resistance
KEGG:05210	0.0141063112147	0.4	CYCS MAPK1	Colorectal cancer
REAC:R-HSA-109606	0.0164283536306	0.4	CYCS MAPK1	Intrinsic Pathway for Apoptosis
KEGG:05145	0.0185363159266	0.4	CYCS MAPK1	Toxoplasmosis
KEGG:04210	0.0327287628992	0.4	CYCS MAPK1	Apoptosis
WP:WP4666	0.0341988987854	0.4	CYCS MAPK1	Hepatitis B infection
MIRNA:hsa-miR-3936	0.0376213618901	0.4	NONO MAPK1	hsa-miR-3936
KEGG:05160	0.038710268063	0.4	CYCS MAPK1	Hepatitis C
KEGG:05164	0.0457961859483	0.4	CYCS MAPK1	Influenza A
KEGG:05152	0.0470338525035	0.4	CYCS MAPK1	Tuberculosis
KEGG:05010	0.0495576477539	0.4	CYCS MAPK1	Alzheimer disease
CORUM:57	0.0499494897235	0.2	MAPK1	HDAC4-ERK2 complex
CORUM:330	0.0499494897235	0.2	NONO	PSF-p54(nrb) complex
CORUM:1248	0.0499494897235	0.2	CYCS	Apoptosome

Protein 1	Protein 2	Score	Precision	Evidence
CYCS	NONO	0.146	0.408	bioplex (NONO) boldt fraction boldt_WMM
MAPK1	NONO	0.119	0.392	bioplex_WMM boldt fraction boldt_WMM treiber_WMM
NONO	PROSER1	0.055	0.311	bioplex (NONO) bioplex_WMM
TET2	NONO	0.048	0.293	bioplex (NONO) bioplex_WMM
TET2	PROSER1	0.009	0.099	bioplex_WMM youn_WMM WMM_only
MAPK1	PROSER1	0.007	0.003	youn_WMM WMM_only

Click to enlarge

Complex HuMAP2_02168 has an average edge precision of 0.251 which is ranked 5362 out of all 6965 complexes.