hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02172
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KMT2A | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | UniProt NCBI |
| KMT2B | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) | UniProt NCBI |
| CXXC1 | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | UniProt NCBI |
| SETD1A | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.43) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | UniProt NCBI |
| BOD1L1 | Biorientation of chromosomes in cell division protein 1-like 1 | UniProt NCBI |
| SETD1B | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.43) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | UniProt NCBI |
| WDR5 | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein) | UniProt NCBI |
| ASH2L | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | UniProt NCBI |
| RBBP5 | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) | UniProt NCBI |
| HCFC2 | Host cell factor 2 (HCF-2) (C2 factor) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6470 | 2.19324782779e-19 | 0.7 | BOD1L1 CXXC1 SETD1B WDR5 RBBP5 HCFC2 ASH2L | Set1B complex |
| GO:0042800 | 2.41331625249e-19 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | histone methyltransferase activity (H3-K4 specific) |
| CORUM:6469 | 2.16441743941e-16 | 0.6 | CXXC1 WDR5 SETD1A RBBP5 HCFC2 ASH2L | Set1A complex |
| GO:0018024 | 2.3007119597e-15 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | histone-lysine N-methyltransferase activity |
| GO:0042054 | 1.40959669731e-14 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | histone methyltransferase activity |
| CORUM:2731 | 1.84266796996e-14 | 0.5 | WDR5 SETD1A RBBP5 CXXC1 ASH2L | Set1A complex |
| CORUM:2730 | 1.84266796996e-14 | 0.5 | WDR5 RBBP5 SETD1B CXXC1 ASH2L | Set1B complex |
| GO:0016279 | 2.80977932526e-14 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | protein-lysine N-methyltransferase activity |
| GO:0016278 | 3.30889940526e-14 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | lysine N-methyltransferase activity |
| GO:0048188 | 3.19913768116e-13 | 0.6 | SETD1B CXXC1 WDR5 SETD1A RBBP5 ASH2L | Set1C/COMPASS complex |
| GO:0008276 | 7.02007303242e-13 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | protein methyltransferase activity |
| REAC:R-HSA-3214841 | 1.02476093069e-12 | 0.7 | SETD1B WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | PKMTs methylate histone lysines |
| GO:0035097 | 1.07869267565e-12 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | histone methyltransferase complex |
| GO:0008170 | 1.62149705431e-12 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | N-methyltransferase activity |
| GO:0051568 | 2.33779682166e-12 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | histone H3-K4 methylation |
| REAC:R-HSA-8936459 | 6.72547703603e-12 | 0.7 | SETD1B WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| CORUM:6457 | 7.6236129225e-12 | 0.4 | WDR5 RBBP5 ASH2L KMT2A | MLL1 core complex |
| GO:0034708 | 1.20900867184e-11 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | methyltransferase complex |
| CORUM:6851 | 3.81057767206e-11 | 0.4 | WDR5 RBBP5 ASH2L KMT2A | MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30) |
| GO:0008757 | 1.10307895563e-10 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | S-adenosylmethionine-dependent methyltransferase activity |
| GO:0034968 | 1.78631383926e-10 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | histone lysine methylation |
| CORUM:1254 | 2.66568478766e-10 | 0.4 | WDR5 RBBP5 ASH2L KMT2B | Menin-associated histone methyltransferase complex |
| CORUM:1256 | 2.66568478766e-10 | 0.4 | WDR5 RBBP5 ASH2L KMT2A | MLL-HCF complex |
| GO:0008168 | 3.45790679056e-10 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | methyltransferase activity |
| GO:0016741 | 5.13533383262e-10 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | transferase activity, transferring one-carbon groups |
| CORUM:6462 | 5.3296507144e-10 | 0.4 | WDR5 RBBP5 ASH2L KMT2A | MLL1 complex |
| GO:0018022 | 6.39245096343e-10 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | peptidyl-lysine methylation |
| GO:0016571 | 9.06754491968e-10 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | histone methylation |
| CORUM:1401 | 1.59786433072e-09 | 0.4 | WDR5 RBBP5 SETD1A KMT2A | MOF complex |
| CORUM:5195 | 1.59786433072e-09 | 0.4 | WDR5 RBBP5 ASH2L KMT2B | PTIP-HMT complex |
| CORUM:6460 | 1.59786433072e-09 | 0.4 | WDR5 RBBP5 ASH2L HCFC2 | MLL2 complex |
| REAC:R-HSA-8878171 | 3.2658629553e-09 | 0.7 | SETD1B WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | Transcriptional regulation by RUNX1 |
| GO:0006479 | 8.00624855491e-09 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | protein methylation |
| GO:0008213 | 8.00624855491e-09 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | protein alkylation |
| REAC:R-HSA-4839726 | 1.3904522139e-08 | 0.7 | SETD1B WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | Chromatin organization |
| REAC:R-HSA-3247509 | 1.3904522139e-08 | 0.7 | SETD1B WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | Chromatin modifying enzymes |
| CORUM:6850 | 1.62176028613e-08 | 0.3 | WDR5 ASH2L RBBP5 | WRA complex (WDR5, RBBP5, ASH2L) |
| CORUM:6849 | 6.48475406063e-08 | 0.3 | WDR5 ASH2L RBBP5 | WRAD complex (WDR5, RBBP5, ASH2L, DPY30) |
| CORUM:6845 | 6.48475406063e-08 | 0.3 | WDR5 ASH2L RBBP5 | NIF1-ASH2L-RBBP5-WDR5 complex |
| CORUM:7367 | 6.48475406063e-08 | 0.3 | WDR5 ASH2L RBBP5 | ASH2L-KDM6B-KDM6B-WDR5 complex |
| CORUM:1399 | 6.48475406063e-08 | 0.3 | WDR5 ASH2L RBBP5 | WDR5-ASH2L-RBBP5-MLL2 complex |
| GO:0045652 | 9.78090078193e-08 | 0.6 | WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | regulation of megakaryocyte differentiation |
| GO:0030219 | 1.26426213072e-07 | 0.6 | WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | megakaryocyte differentiation |
| CORUM:5386 | 1.32805454073e-07 | 0.4 | WDR5 RBBP5 ASH2L KMT2A | MLL1-WDR5 complex |
| GO:0043414 | 5.24257774584e-07 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | macromolecule methylation |
| GO:0032259 | 8.86896527643e-07 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | methylation |
| CORUM:6461 | 1.35939923621e-06 | 0.3 | WDR5 ASH2L RBBP5 | MLL3 complex |
| CORUM:6467 | 1.35939923621e-06 | 0.3 | WDR5 ASH2L RBBP5 | MLL4 complex |
| KEGG:00310 | 2.523804843e-06 | 0.4 | KMT2A SETD1B SETD1A KMT2B | Lysine degradation |
| CORUM:3075 | 3.55656615278e-06 | 0.3 | WDR5 ASH2L RBBP5 | UTX-MLL2/3 complex |
| WP:WP2369 | 4.51826231782e-06 | 0.4 | KMT2A SETD1B SETD1A KMT2B | Histone Modifications |
| GO:0018205 | 5.11181727015e-06 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | peptidyl-lysine modification |
| GO:0045637 | 1.0810551949e-05 | 0.6 | WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | regulation of myeloid cell differentiation |
| GO:0006325 | 1.0889816169e-05 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | chromatin organization |
| GO:0016570 | 1.2532575542e-05 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | histone modification |
| CORUM:2721 | 1.31637369008e-05 | 0.3 | WDR5 ASH2L SETD1A | HCF-1 complex |
| GO:0016569 | 1.71906868138e-05 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | covalent chromatin modification |
| CORUM:0000000 | 3.01031808081e-05 | 1.0 | BOD1L1 CXXC1 SETD1B WDR5 SETD1A RBBP5 KMT2B HCFC2 KMT2A ASH2L | CORUM root |
| GO:1990234 | 4.68463310657e-05 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | transferase complex |
| CORUM:1257 | 5.26623941492e-05 | 0.3 | WDR5 RBBP5 KMT2A | ALL-1 supercomplex |
| KEGG:04934 | 7.43511629847e-05 | 0.4 | WDR5 RBBP5 ASH2L KMT2A | Cushing syndrome |
| GO:0030099 | 0.000133486868504 | 0.6 | WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | myeloid cell differentiation |
| REAC:R-HSA-212436 | 0.000158873773892 | 0.7 | SETD1B WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | Generic Transcription Pathway |
| CORUM:6340 | 0.000301566439547 | 0.2 | RBBP5 ASH2L | PITX2-MLL4-ASH2L-RBBP5-PTIP complex |
| REAC:R-HSA-73857 | 0.00033374524047 | 0.7 | SETD1B WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | RNA Polymerase II Transcription |
| GO:0044451 | 0.000410768266253 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | nucleoplasm part |
| GO:0051276 | 0.000443702834808 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | chromosome organization |
| GO:1903706 | 0.0005989919036 | 0.6 | WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | regulation of hemopoiesis |
| CORUM:1400 | 0.000632835990272 | 0.2 | RBBP5 ASH2L | ASCOM complex |
| REAC:R-HSA-74160 | 0.00070013120119 | 0.7 | SETD1B WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | Gene expression (Transcription) |
| GO:0044666 | 0.00179314168727 | 0.3 | WDR5 ASH2L RBBP5 | MLL3/4 complex |
| GO:1902494 | 0.00326458532783 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | catalytic complex |
| GO:0005654 | 0.00998195755149 | 1.0 | BOD1L1 CXXC1 SETD1B WDR5 SETD1A RBBP5 KMT2B HCFC2 KMT2A ASH2L | nucleoplasm |
| GO:0030097 | 0.0107320440947 | 0.6 | WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | hemopoiesis |
| REAC:R-HSA-5619507 | 0.0108219930226 | 0.3 | WDR5 ASH2L RBBP5 | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.0108219930226 | 0.3 | WDR5 ASH2L RBBP5 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| GO:0018193 | 0.0121093775605 | 0.7 | SETD1B CXXC1 WDR5 RBBP5 KMT2B KMT2A ASH2L | peptidyl-amino acid modification |
| GO:0048534 | 0.0124049790497 | 0.6 | WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | hematopoietic or lymphoid organ development |
| GO:0002520 | 0.0179481992183 | 0.6 | WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | immune system development |
| GO:0045322 | 0.020287053512 | 0.2 | KMT2A CXXC1 | unmethylated CpG binding |
| GO:0071339 | 0.0316085885479 | 0.3 | WDR5 RBBP5 KMT2A | MLL1 complex |
| GO:0044665 | 0.0316085885479 | 0.3 | WDR5 RBBP5 KMT2A | MLL1/2 complex |
| GO:0140096 | 0.0493086862327 | 0.8 | SETD1B CXXC1 WDR5 SETD1A RBBP5 KMT2B KMT2A ASH2L | catalytic activity, acting on a protein |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KMT2B | WDR5 | 1.0 | 0.949 | bioplex (WDR5) bioplex_WMM youn_WMM |
| CXXC1 | SETD1B | 0.997 | 0.931 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1,SETD1B) |
| CXXC1 | SETD1A | 0.994 | 0.919 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) fraction |
| SETD1B | WDR5 | 0.981 | 0.896 | hein_WMM bioplex (WDR5) bioplex_WMM hein (SETD1B) |
| CXXC1 | BOD1L1 | 0.98 | 0.896 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (BOD1L1,CXXC1) |
| KMT2B | HCFC2 | 0.97 | 0.881 | bioplex (HCFC2) bioplex_WMM |
| CXXC1 | WDR5 | 0.964 | 0.872 | hein_WMM bioplex (CXXC1,WDR5) bioplex_WMM hein (CXXC1,WDR5) |
| ASH2L | WDR5 | 0.931 | 0.846 | hein_WMM bioplex (WDR5) bioplex_WMM youn_WMM |
| WDR5 | SETD1A | 0.878 | 0.812 | hein_WMM bioplex (WDR5) bioplex_WMM youn_WMM |
| RBBP5 | WDR5 | 0.866 | 0.801 | hein_WMM bioplex (WDR5) bioplex_WMM youn_WMM |
| CXXC1 | ASH2L | 0.677 | 0.706 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) fraction |
| WDR5 | BOD1L1 | 0.635 | 0.685 | hein_WMM bioplex (WDR5) bioplex_WMM youn_WMM |
| CXXC1 | RBBP5 | 0.617 | 0.675 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) |
| HCFC2 | KMT2A | 0.483 | 0.613 | hein_WMM bioplex (HCFC2) bioplex_WMM youn_WMM |
| WDR5 | KMT2A | 0.273 | 0.486 | hein_WMM bioplex (WDR5) bioplex_WMM youn_WMM gupta_WMM |
| SETD1A | BOD1L1 | 0.157 | 0.416 | hein_WMM bioplex_WMM youn_WMM hein (BOD1L1) |
| ASH2L | HCFC2 | 0.078 | 0.353 | hein_WMM bioplex (HCFC2) bioplex_WMM |
| HCFC2 | SETD1A | 0.06 | 0.336 | bioplex (HCFC2) bioplex_WMM youn_WMM |
| RBBP5 | SETD1B | 0.043 | 0.269 | hein_WMM bioplex_WMM youn_WMM hein (SETD1B) |
| RBBP5 | HCFC2 | 0.037 | 0.265 | bioplex (HCFC2) bioplex_WMM |
| RBBP5 | ASH2L | 0.034 | 0.26 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CXXC1 | HCFC2 | 0.026 | 0.219 | bioplex (CXXC1,HCFC2) bioplex_WMM |
| ASH2L | SETD1B | 0.016 | 0.155 | hein_WMM bioplex_WMM youn_WMM hein (SETD1B) |
| HCFC2 | WDR5 | 0.014 | 0.144 | hein_WMM bioplex (HCFC2,WDR5) bioplex_WMM |
| HCFC2 | BOD1L1 | 0.013 | 0.147 | bioplex (HCFC2) bioplex_WMM youn_WMM |
| ASH2L | BOD1L1 | 0.012 | 0.147 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RBBP5 | SETD1A | 0.011 | 0.142 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| KMT2B | KMT2A | 0.011 | 0.145 | bioplex_WMM youn_WMM WMM_only |
| KMT2B | BOD1L1 | 0.01 | 0.142 | bioplex_WMM youn_WMM WMM_only |
| SETD1B | SETD1A | 0.01 | 0.129 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| KMT2A | BOD1L1 | 0.01 | 0.121 | bioplex_WMM youn_WMM WMM_only |
| SETD1B | BOD1L1 | 0.01 | 0.105 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| KMT2B | SETD1A | 0.01 | 0.101 | bioplex_WMM youn_WMM WMM_only |
| SETD1A | KMT2A | 0.009 | 0.115 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ASH2L | KMT2B | 0.009 | 0.107 | bioplex_WMM youn_WMM WMM_only |
| RBBP5 | KMT2B | 0.009 | 0.108 | bioplex_WMM youn_WMM WMM_only |
| CXXC1 | KMT2B | 0.009 | 0.1 | bioplex_WMM youn_WMM WMM_only |
| ASH2L | KMT2A | 0.009 | 0.103 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SETD1B | KMT2B | 0.009 | 0.091 | bioplex_WMM youn_WMM WMM_only |
| RBBP5 | KMT2A | 0.008 | 0.087 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SETD1B | KMT2A | 0.008 | 0.085 | bioplex_WMM youn_WMM WMM_only |
| CXXC1 | KMT2A | 0.008 | 0.07 | bioplex_WMM youn_WMM WMM_only |
| SETD1B | HCFC2 | 0.008 | 0.059 | bioplex_WMM WMM_only |
| RBBP5 | BOD1L1 | 0.005 | 0.007 | hein_WMM bioplex_WMM youn_WMM hein (BOD1L1) |
| ASH2L | SETD1A | 0.0 | 0.014 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_02172 has an average edge precision of 0.367 which is ranked 3677 out of all 6965 complexes.
Related Complexes