hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02178
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MYO18A | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | UniProt NCBI |
| MYH14 | Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C) | UniProt NCBI |
| MYL12B | Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1) | UniProt NCBI |
| ACTRT1 | Actin-related protein T1 (ARP-T1) | UniProt NCBI |
| MYL6B | Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B) | UniProt NCBI |
| LIMCH1 | LIM and calponin homology domains-containing protein 1 | UniProt NCBI |
| SYNPO | Synaptopodin | UniProt NCBI |
| MYH9 | Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) | UniProt NCBI |
| IQGAP3 | Ras GTPase-activating-like protein IQGAP3 | UniProt NCBI |
| MYL6 | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | UniProt NCBI |
| MYH10 | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04530 | 1.03101357765e-10 | 0.636363636364 | MYL6 SYNPO MYL6B MYH14 MYH9 MYH10 MYL12B | Tight junction |
| REAC:R-HSA-416572 | 1.92112435197e-10 | 0.454545454545 | MYL6 MYH14 MYH10 MYL12B MYH9 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5625900 | 1.92112435197e-10 | 0.454545454545 | MYL6 MYH14 MYH10 MYL12B MYH9 | RHO GTPases activate CIT |
| REAC:R-HSA-5627117 | 1.92112435197e-10 | 0.454545454545 | MYL6 MYH14 MYH10 MYL12B MYH9 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5627123 | 2.56063835949e-10 | 0.454545454545 | MYL6 MYH14 MYH10 MYL12B MYH9 | RHO GTPases activate PAKs |
| REAC:R-HSA-400685 | 5.55186257817e-10 | 0.454545454545 | MYL6 MYH14 MYH10 MYL12B MYH9 | Sema4D in semaphorin signaling |
| REAC:R-HSA-3928663 | 1.08423247185e-09 | 0.454545454545 | MYL6 MYH14 MYH10 MYL12B MYH9 | EPHA-mediated growth cone collapse |
| GO:0016459 | 1.67612320464e-09 | 0.545454545455 | MYL6 MYL6B LIMCH1 MYH14 MYH9 MYH10 | myosin complex |
| GO:0042641 | 5.4537424476e-08 | 0.545454545455 | MYO18A SYNPO LIMCH1 MYH14 MYH9 MYH10 | actomyosin |
| REAC:R-HSA-373755 | 8.16076088605e-08 | 0.454545454545 | MYL6 MYH14 MYH10 MYL12B MYH9 | Semaphorin interactions |
| GO:0016460 | 9.90978452533e-08 | 0.454545454545 | MYH14 MYH10 LIMCH1 MYL6B MYH9 | myosin II complex |
| REAC:R-HSA-2682334 | 5.62551831799e-07 | 0.454545454545 | MYL6 MYH14 MYH10 MYL12B MYH9 | EPH-Ephrin signaling |
| REAC:R-HSA-5625740 | 8.37516579484e-07 | 0.454545454545 | MYL6 MYH14 MYH10 MYL12B MYH9 | RHO GTPases activate PKNs |
| GO:0030898 | 1.01246124774e-06 | 0.363636363636 | MYH14 MYH10 MYH9 MYL6 | actin-dependent ATPase activity |
| GO:0015629 | 1.49081219785e-06 | 0.727272727273 | MYL6 MYO18A MYH10 SYNPO MYL6B MYH14 MYH9 LIMCH1 | actin cytoskeleton |
| KEGG:04810 | 5.78968916019e-06 | 0.454545454545 | MYH14 MYH10 MYL12B IQGAP3 MYH9 | Regulation of actin cytoskeleton |
| REAC:R-HSA-195258 | 7.05339766305e-06 | 0.545454545455 | MYL6 IQGAP3 MYH14 MYL12B MYH10 MYH9 | RHO GTPase Effectors |
| GO:0097513 | 1.49850650438e-05 | 0.272727272727 | MYH14 MYH9 MYH10 | myosin II filament |
| GO:0030029 | 3.40724571526e-05 | 0.727272727273 | MYL6 MYO18A MYH10 SYNPO MYL6B MYH14 MYH9 LIMCH1 | actin filament-based process |
| REAC:R-HSA-194315 | 5.0121930858e-05 | 0.545454545455 | MYL6 IQGAP3 MYH14 MYL12B MYH10 MYH9 | Signaling by Rho GTPases |
| REAC:R-HSA-445355 | 0.000354278963792 | 0.272727272727 | MYL6 MYL6B MYL12B | Smooth Muscle Contraction |
| CORUM:486 | 0.00050247669008 | 0.181818181818 | MYL6 MYH9 | WIP-WASp-actin-myosin-IIa complex |
| GO:0032982 | 0.000837474301274 | 0.272727272727 | MYH14 MYH9 MYH10 | myosin filament |
| GO:0031032 | 0.00140269047354 | 0.454545454545 | MYH14 MYH10 MYO18A MYH9 LIMCH1 | actomyosin structure organization |
| GO:0097517 | 0.00167705989078 | 0.363636363636 | SYNPO MYH10 MYH9 LIMCH1 | contractile actin filament bundle |
| GO:0001725 | 0.00167705989078 | 0.363636363636 | SYNPO MYH10 MYH9 LIMCH1 | stress fiber |
| GO:0032432 | 0.00249850568129 | 0.363636363636 | SYNPO MYH10 MYH9 LIMCH1 | actin filament bundle |
| REAC:R-HSA-422475 | 0.00405504349953 | 0.454545454545 | MYL6 MYH14 MYH10 MYL12B MYH9 | Axon guidance |
| GO:0008092 | 0.00795425159776 | 0.636363636364 | MYO18A IQGAP3 SYNPO LIMCH1 MYH14 MYH9 MYH10 | cytoskeletal protein binding |
| GO:0044430 | 0.0106952876619 | 0.727272727273 | MYL6 MYO18A MYH10 SYNPO MYL6B MYH14 MYH9 LIMCH1 | cytoskeletal part |
| KEGG:05130 | 0.0114336243325 | 0.272727272727 | MYH14 MYH9 MYH10 | Pathogenic Escherichia coli infection |
| GO:0030036 | 0.0271582078479 | 0.545454545455 | MYO18A SYNPO LIMCH1 MYH14 MYH9 MYH10 | actin cytoskeleton organization |
| WP:WP4352 | 0.0291755615244 | 0.272727272727 | IQGAP3 MYL6B MYL6 | Ciliary landscape |
| GO:0003774 | 0.0304462237354 | 0.363636363636 | MYL6 MYH10 MYL6B MYH9 | motor activity |
| GO:0003779 | 0.0356702818862 | 0.454545454545 | MYH14 MYH10 MYO18A MYH9 SYNPO | actin binding |
| GO:0030048 | 0.037045922265 | 0.363636363636 | MYL6 MYH10 MYL6B MYH9 | actin filament-based movement |
| GO:0043531 | 0.0434092832834 | 0.272727272727 | MYO18A MYH9 MYH10 | ADP binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MYH9 | MYH10 | 0.981 | 0.897 | hein_WMM bioplex (MYH9) bioplex_WMM boldt youn_WMM hein (MYH10,MYH9) gupta_WMM boldt_WMM treiber_WMM |
| MYL6 | MYO18A | 0.98 | 0.896 | hein_WMM bioplex (MYL6) bioplex_WMM hein (MYO18A) |
| MYL12B | MYL6 | 0.875 | 0.809 | hein_WMM bioplex (MYL6) bioplex_WMM boldt youn_WMM hein (MYL12B) gupta_WMM boldt_WMM treiber_WMM |
| MYL6 | MYH9 | 0.743 | 0.739 | hein_WMM bioplex (MYH9,MYL6) bioplex_WMM boldt youn_WMM hein (MYH9) gupta_WMM boldt_WMM treiber_WMM |
| MYL12B | MYH9 | 0.604 | 0.672 | hein_WMM bioplex (MYH9) bioplex_WMM boldt youn_WMM hein (MYH9,MYL12B) gupta_WMM boldt_WMM treiber_WMM |
| MYL6 | MYL6B | 0.26 | 0.482 | hein_WMM bioplex (MYL6) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| MYL6 | MYH10 | 0.12 | 0.392 | hein_WMM bioplex (MYL6) bioplex_WMM boldt youn_WMM hein (MYH10) gupta_WMM boldt_WMM treiber_WMM |
| MYL12B | MYO18A | 0.102 | 0.364 | hein_WMM bioplex_WMM hein (MYL12B,MYO18A) |
| MYH14 | MYL6 | 0.071 | 0.353 | bioplex (MYL6) bioplex_WMM gupta_WMM boldt_WMM treiber_WMM |
| MYH9 | ACTRT1 | 0.052 | 0.304 | hein_WMM hein (MYH9) |
| IQGAP3 | MYL6 | 0.044 | 0.281 | bioplex (MYL6) bioplex_WMM boldt youn_WMM boldt_WMM |
| MYH9 | SYNPO | 0.043 | 0.269 | hein_WMM hein (MYH9) |
| MYO18A | LIMCH1 | 0.039 | 0.264 | hein_WMM bioplex_WMM hein (MYO18A) |
| MYO18A | MYH9 | 0.028 | 0.23 | hein_WMM bioplex_WMM hein (MYH9,MYO18A) treiber_WMM |
| MYL12B | MYL6B | 0.02 | 0.186 | hein_WMM bioplex_WMM hein (MYL12B) gupta_WMM treiber_WMM |
| MYL12B | MYH10 | 0.02 | 0.186 | hein_WMM bioplex_WMM boldt youn_WMM hein (MYH10) gupta_WMM boldt_WMM |
| MYL6B | LIMCH1 | 0.012 | 0.149 | hein_WMM bioplex (LIMCH1) bioplex_WMM |
| MYH14 | MYH9 | 0.01 | 0.1 | bioplex_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM |
| SYNPO | ACTRT1 | 0.009 | 0.09 | hein_WMM WMM_only |
| MYH14 | MYL12B | 0.009 | 0.097 | bioplex_WMM gupta_WMM WMM_only boldt_WMM |
| MYH14 | MYL6B | 0.008 | 0.083 | bioplex_WMM gupta_WMM WMM_only |
| MYL12B | LIMCH1 | 0.008 | 0.043 | hein_WMM bioplex (LIMCH1) bioplex_WMM youn_WMM gupta_WMM |
| MYL6B | MYH10 | 0.007 | 0.009 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| MYH9 | MYL6B | 0.007 | 0.003 | hein_WMM bioplex (MYH9) bioplex_WMM youn_WMM hein (MYH9) gupta_WMM treiber_WMM |
| MYL6B | ACTRT1 | 0.007 | 0.008 | hein_WMM WMM_only |
| MYH14 | MYO18A | 0.007 | 0.004 | bioplex_WMM WMM_only treiber_WMM |
| IQGAP3 | LIMCH1 | 0.007 | 0.005 | youn_WMM WMM_only |
| LIMCH1 | ACTRT1 | 0.007 | 0.002 | hein_WMM WMM_only |
| MYH14 | MYH10 | 0.007 | 0.001 | bioplex_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM |
| ACTRT1 | MYH10 | 0.007 | 0.001 | hein_WMM WMM_only |
| MYL12B | ACTRT1 | 0.007 | 0.003 | hein_WMM WMM_only |
| MYH14 | IQGAP3 | 0.007 | 0.003 | bioplex_WMM WMM_only treiber_WMM |
| MYL6 | ACTRT1 | 0.007 | 0.008 | hein_WMM WMM_only |
| MYH14 | LIMCH1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| MYL12B | IQGAP3 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only boldt_WMM |
| MYL6 | LIMCH1 | 0.007 | 0.002 | hein_WMM bioplex (LIMCH1) bioplex_WMM youn_WMM gupta_WMM |
| IQGAP3 | MYL6B | 0.006 | 0.004 | bioplex_WMM boldt boldt_WMM |
| IQGAP3 | MYO18A | 0.006 | 0.008 | bioplex_WMM WMM_only treiber_WMM |
| MYO18A | ACTRT1 | 0.006 | 0.006 | hein_WMM WMM_only |
| IQGAP3 | MYH10 | 0.006 | 0.001 | hein_WMM bioplex_WMM WMM_only boldt_WMM treiber_WMM |
| IQGAP3 | MYH9 | 0.006 | 0.006 | bioplex_WMM youn_WMM WMM_only boldt_WMM treiber_WMM |
| MYL6B | SYNPO | 0.006 | 0.002 | hein_WMM WMM_only |
| MYL12B | SYNPO | 0.006 | 0.002 | hein_WMM WMM_only |
| LIMCH1 | SYNPO | 0.006 | 0.001 | hein_WMM WMM_only |
| MYL6 | SYNPO | 0.006 | 0.007 | hein_WMM WMM_only boldt_WMM |
| MYO18A | MYH10 | 0.005 | 0.009 | hein_WMM bioplex_WMM hein (MYH10) treiber_WMM |
| MYO18A | SYNPO | 0.005 | 0.009 | hein_WMM WMM_only |
| MYO18A | MYL6B | 0.005 | 0.014 | hein_WMM bioplex_WMM hein (MYO18A) |
| MYH9 | LIMCH1 | 0.003 | 0.02 | hein_WMM bioplex (LIMCH1) bioplex_WMM youn_WMM hein (MYH9) gupta_WMM |
| SYNPO | MYH10 | 0.0 | 0.012 | hein_WMM hein (MYH10) |
| LIMCH1 | MYH10 | 0.0 | 0.008 | hein_WMM bioplex (LIMCH1) bioplex_WMM youn_WMM hein (MYH10) gupta_WMM |
Images
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Complex HuMAP2_02178 has an average edge precision of 0.158 which is ranked 6648 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MYO18A | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04655 |
| MYH14 | HuMAP2_01307 HuMAP2_02178 HuMAP2_04152 |
| MYL12B | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04655 |
| ACTRT1 | HuMAP2_02178 HuMAP2_03956 |
| MYL6B | HuMAP2_02178 HuMAP2_04152 |
| LIMCH1 | HuMAP2_02178 |
| SYNPO | HuMAP2_02178 HuMAP2_03582 HuMAP2_04615 HuMAP2_05394 HuMAP2_05638 |
| MYH9 | HuMAP2_02160 HuMAP2_02178 HuMAP2_03239 HuMAP2_03956 HuMAP2_06706 |
| IQGAP3 | HuMAP2_01307 HuMAP2_02178 HuMAP2_04152 |
| MYL6 | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04152 HuMAP2_04655 |
| MYH10 | HuMAP2_02178 HuMAP2_03239 HuMAP2_03956 HuMAP2_04152 |