hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02188
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CYTH2 | Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) | UniProt NCBI |
| CYTH3 | Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3) | UniProt NCBI |
| CYTH1 | Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1) | UniProt NCBI |
| CCDC120 | Coiled-coil domain-containing protein 120 | UniProt NCBI |
| CYTIP | Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) | UniProt NCBI |
| INAVA | Innate immunity activator protein | UniProt NCBI |
| IPCEF1 | Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) | UniProt NCBI |
| CNKSR1 | Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6811438 | 0.000236398544274 | 0.375 | CYTH1 CYTH2 CYTH3 | Intra-Golgi traffic |
| GO:0005086 | 0.00111635111712 | 0.375 | CYTH1 CYTH2 CYTH3 | ARF guanyl-nucleotide exchange factor activity |
| KEGG:04072 | 0.00154310698075 | 0.375 | CYTH1 CYTH2 CYTH3 | Phospholipase D signaling pathway |
| KEGG:05130 | 0.00425215180026 | 0.375 | CYTH1 CYTH2 CYTH3 | Pathogenic Escherichia coli infection |
| KEGG:04144 | 0.00936072825747 | 0.375 | CYTH1 CYTH2 CYTH3 | Endocytosis |
| REAC:R-HSA-6811442 | 0.021548816785 | 0.375 | CYTH1 CYTH2 CYTH3 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| CORUM:1063 | 0.0248670854284 | 0.125 | CYTH3 | GRASP-GRP1 complex |
| CORUM:5926 | 0.0248670854284 | 0.125 | CNKSR1 | CNK1 homodimer complex |
| CORUM:5924 | 0.0497224828424 | 0.125 | CNKSR1 | RAF1-CNK1 complex, RAS stimulated |
| CORUM:5925 | 0.0497224828424 | 0.125 | CNKSR1 | BRAF-CNK1 complex, not RAS stimulated |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CYTH1 | CYTIP | 1.0 | 0.949 | bioplex (CYTIP) bioplex_WMM |
| CYTH2 | CYTIP | 0.997 | 0.93 | bioplex (CYTIP) bioplex_WMM |
| CYTH3 | CYTIP | 0.778 | 0.752 | bioplex (CYTIP) bioplex_WMM |
| CYTH2 | CNKSR1 | 0.762 | 0.749 | bioplex (CNKSR1) |
| CYTH1 | CNKSR1 | 0.645 | 0.687 | bioplex (CNKSR1) |
| IPCEF1 | CYTH1 | 0.632 | 0.681 | bioplex (IPCEF1) bioplex_WMM |
| IPCEF1 | CYTH2 | 0.601 | 0.671 | bioplex (IPCEF1) bioplex_WMM |
| CYTH3 | CNKSR1 | 0.306 | 0.501 | bioplex (CNKSR1) |
| IPCEF1 | CYTH3 | 0.192 | 0.446 | bioplex (IPCEF1) bioplex_WMM |
| CCDC120 | CYTH2 | 0.066 | 0.348 | bioplex (CCDC120) bioplex_WMM |
| CCDC120 | CYTH1 | 0.052 | 0.3 | bioplex (CCDC120) bioplex_WMM |
| CYTH2 | INAVA | 0.035 | 0.26 | bioplex (INAVA) bioplex_WMM |
| CYTH1 | INAVA | 0.024 | 0.214 | bioplex (INAVA) bioplex_WMM |
| CYTH1 | CYTH2 | 0.019 | 0.181 | bioplex_WMM WMM_only |
| CYTH2 | CYTH3 | 0.017 | 0.174 | bioplex_WMM WMM_only |
| CYTH1 | CYTH3 | 0.016 | 0.161 | bioplex_WMM WMM_only |
| CCDC120 | CYTH3 | 0.013 | 0.144 | bioplex (CCDC120) bioplex_WMM |
| CYTH3 | INAVA | 0.012 | 0.15 | bioplex (INAVA) bioplex_WMM |
Images
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Complex HuMAP2_02188 has an average edge precision of 0.461 which is ranked 2793 out of all 6965 complexes.
Related Complexes