hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02199
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRDM10 | PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) (Tristanin) | UniProt NCBI |
| GOLGA7 | Golgin subfamily A member 7 (Golgi complex-associated protein of 16 kDa) | UniProt NCBI |
| NBEAL1 | Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) | UniProt NCBI |
| SULF1 | Extracellular sulfatase Sulf-1 (hSulf-1) (EC 3.1.6.-) | UniProt NCBI |
| TMEFF1 | Tomoregulin-1 (TR-1) (H7365) (Transmembrane protein with EGF-like and one follistatin-like domain) | UniProt NCBI |
| DHRS2 | Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1) | UniProt NCBI |
| SDC2 | Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362) | UniProt NCBI |
| SDC1 | Syndecan-1 (SYND1) (CD antigen CD138) | UniProt NCBI |
| FGF2 | Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) | UniProt NCBI |
| SDC4 | Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3000170 | 3.18193650843e-07 | 0.4 | SDC2 FGF2 SDC4 SDC1 | Syndecan interactions |
| REAC:R-HSA-3000171 | 8.32359312483e-06 | 0.4 | SDC2 FGF2 SDC4 SDC1 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-3656253 | 1.65338728209e-05 | 0.3 | SDC2 SDC4 SDC1 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-3656237 | 1.65338728209e-05 | 0.3 | SDC2 SDC4 SDC1 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-3560783 | 4.39370578466e-05 | 0.3 | SDC2 SDC4 SDC1 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-4420332 | 4.39370578466e-05 | 0.3 | SDC2 SDC4 SDC1 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3560801 | 4.39370578466e-05 | 0.3 | SDC2 SDC4 SDC1 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-2024096 | 6.0263228955e-05 | 0.3 | SDC2 SDC4 SDC1 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 9.16118331264e-05 | 0.3 | SDC2 SDC4 SDC1 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 0.000165098589509 | 0.3 | SDC2 SDC4 SDC1 | HS-GAG biosynthesis |
| KEGG:05205 | 0.000233940185601 | 0.4 | SDC2 FGF2 SDC4 SDC1 | Proteoglycans in cancer |
| REAC:R-HSA-3560782 | 0.000411472353333 | 0.3 | SDC2 SDC4 SDC1 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 0.000479614787766 | 0.3 | SDC2 SDC4 SDC1 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.000595243365748 | 0.3 | SDC2 SDC4 SDC1 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-1793185 | 0.000728001600925 | 0.3 | SDC2 SDC4 SDC1 | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-1638091 | 0.00087904559287 | 0.3 | SDC2 SDC4 SDC1 | Heparan sulfate/heparin (HS-GAG) metabolism |
| GO:0006027 | 0.00116245674185 | 0.4 | SDC2 FGF2 SDC4 SDC1 | glycosaminoglycan catabolic process |
| GO:0006026 | 0.00159423941993 | 0.4 | SDC2 FGF2 SDC4 SDC1 | aminoglycan catabolic process |
| KEGG:04514 | 0.00168693359085 | 0.3 | SDC2 SDC4 SDC1 | Cell adhesion molecules (CAMs) |
| REAC:R-HSA-2187338 | 0.00300181929167 | 0.3 | SDC2 SDC4 SDC1 | Visual phototransduction |
| KEGG:05418 | 0.00318926561715 | 0.3 | SDC2 SDC4 SDC1 | Fluid shear stress and atherosclerosis |
| REAC:R-HSA-1474244 | 0.00407503752083 | 0.4 | SDC2 FGF2 SDC4 SDC1 | Extracellular matrix organization |
| REAC:R-HSA-202733 | 0.00756040058613 | 0.3 | SDC2 SDC4 SDC1 | Cell surface interactions at the vascular wall |
| REAC:R-HSA-1630316 | 0.00973605157338 | 0.3 | SDC2 SDC4 SDC1 | Glycosaminoglycan metabolism |
| KEGG:05144 | 0.0101858362789 | 0.2 | SDC2 SDC1 | Malaria |
| REAC:R-HSA-3781865 | 0.0132265636945 | 0.3 | SDC2 SDC4 SDC1 | Diseases of glycosylation |
| REAC:R-HSA-196854 | 0.0345790439207 | 0.3 | SDC2 SDC4 SDC1 | Metabolism of vitamins and cofactors |
| GO:0030203 | 0.0378914716756 | 0.4 | SDC2 FGF2 SDC4 SDC1 | glycosaminoglycan metabolic process |
| MIRNA:hsa-miR-5688 | 0.0380403957621 | 0.3 | TMEFF1 FGF2 SDC2 | hsa-miR-5688 |
| GO:0006022 | 0.0462322956675 | 0.4 | SDC2 FGF2 SDC4 SDC1 | aminoglycan metabolic process |
| MIRNA:hsa-miR-495-3p | 0.0469852659169 | 0.3 | TMEFF1 FGF2 SDC2 | hsa-miR-495-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FGF2 | TMEFF1 | 0.562 | 0.65 | bioplex (TMEFF1) bioplex_WMM |
| TMEFF1 | DHRS2 | 0.146 | 0.408 | bioplex (TMEFF1) bioplex_WMM |
| SDC2 | DHRS2 | 0.118 | 0.391 | bioplex (SDC2) bioplex_WMM |
| SDC2 | FGF2 | 0.063 | 0.347 | bioplex (SDC2) bioplex_WMM boldt_WMM |
| SDC2 | NBEAL1 | 0.053 | 0.301 | bioplex (SDC2) bioplex_WMM |
| FGF2 | SDC1 | 0.044 | 0.28 | bioplex (SDC1) bioplex_WMM |
| SDC2 | PRDM10 | 0.037 | 0.266 | bioplex (SDC2) bioplex_WMM |
| SDC2 | SDC4 | 0.029 | 0.232 | bioplex (SDC2) bioplex_WMM |
| DHRS2 | SDC1 | 0.029 | 0.231 | bioplex (SDC1) bioplex_WMM |
| GOLGA7 | TMEFF1 | 0.027 | 0.229 | bioplex (TMEFF1) bioplex_WMM |
| SDC2 | SULF1 | 0.021 | 0.194 | bioplex (SDC2) bioplex_WMM |
| PRDM10 | SDC1 | 0.021 | 0.189 | bioplex (SDC1) bioplex_WMM |
| FGF2 | DHRS2 | 0.013 | 0.155 | bioplex_WMM WMM_only |
| FGF2 | PRDM10 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| PRDM10 | DHRS2 | 0.011 | 0.144 | bioplex_WMM WMM_only |
| TMEFF1 | SDC4 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| NBEAL1 | SDC4 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| TMEFF1 | SDC1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SDC2 | TMEFF1 | 0.008 | 0.08 | bioplex_WMM WMM_only |
| FGF2 | NBEAL1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| SDC4 | SDC1 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| NBEAL1 | SULF1 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| NBEAL1 | DHRS2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| GOLGA7 | FGF2 | 0.008 | 0.059 | bioplex_WMM WMM_only |
| PRDM10 | NBEAL1 | 0.008 | 0.047 | bioplex_WMM WMM_only |
| SDC2 | SDC1 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| FGF2 | SDC4 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| GOLGA7 | DHRS2 | 0.008 | 0.023 | bioplex_WMM WMM_only |
| SULF1 | SDC4 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| DHRS2 | SDC4 | 0.008 | 0.012 | bioplex_WMM WMM_only |
| PRDM10 | SDC4 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| FGF2 | SULF1 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| GOLGA7 | PRDM10 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| DHRS2 | SULF1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PRDM10 | SULF1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| TMEFF1 | PRDM10 | 0.0 | 0.0 | bioplex (TMEFF1) bioplex_WMM |
Images
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Complex HuMAP2_02199 has an average edge precision of 0.141 which is ranked 6767 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRDM10 | HuMAP2_01604 HuMAP2_02199 HuMAP2_03877 |
| GOLGA7 | HuMAP2_00899 HuMAP2_02199 HuMAP2_02858 HuMAP2_05963 |
| NBEAL1 | HuMAP2_01740 HuMAP2_02199 HuMAP2_04691 |
| SULF1 | HuMAP2_02199 HuMAP2_04691 |
| TMEFF1 | HuMAP2_01569 HuMAP2_02199 HuMAP2_06778 |
| DHRS2 | HuMAP2_01740 HuMAP2_02199 |
| SDC2 | HuMAP2_00939 HuMAP2_01740 HuMAP2_02199 HuMAP2_04691 |
| SDC1 | HuMAP2_02199 |
| FGF2 | HuMAP2_01569 HuMAP2_02199 |
| SDC4 | HuMAP2_02199 HuMAP2_03731 HuMAP2_04691 HuMAP2_04797 |