hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02200
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KDM2B | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | UniProt NCBI |
| RNF2 | E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2) | UniProt NCBI |
| PCGF6 | Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) | UniProt NCBI |
| PCGF1 | Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) | UniProt NCBI |
| RYBP | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | UniProt NCBI |
| RING1 | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | UniProt NCBI |
| BCOR | BCL-6 corepressor (BCoR) | UniProt NCBI |
| YAF2 | YY1-associated factor 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1178 | 2.39587484326e-18 | 0.75 | RING1 PCGF1 RNF2 RYBP BCOR KDM2B | BCOR complex |
| GO:0035518 | 2.41347674848e-16 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | histone H2A monoubiquitination |
| GO:0033522 | 5.9626307868e-15 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | histone H2A ubiquitination |
| GO:0010390 | 1.93554495458e-14 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | histone monoubiquitination |
| GO:0016574 | 3.99286457326e-13 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | histone ubiquitination |
| GO:0006513 | 4.2231721809e-12 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | protein monoubiquitination |
| REAC:R-HSA-8953750 | 4.50456749059e-10 | 0.625 | PCGF6 RYBP YAF2 RNF2 RING1 | Transcriptional Regulation by E2F6 |
| CORUM:1194 | 7.81346056655e-10 | 0.5 | PCGF6 RNF2 YAF2 RING1 | E2F-6 complex |
| GO:0031519 | 8.61825625718e-10 | 0.75 | RING1 PCGF1 RYBP RNF2 PCGF6 KDM2B | PcG protein complex |
| WP:WP4553 | 7.96421488284e-08 | 0.5 | BCOR RNF2 PCGF1 KDM2B | FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma |
| GO:0070317 | 1.98894336804e-07 | 0.625 | PCGF6 RYBP YAF2 RNF2 RING1 | negative regulation of G0 to G1 transition |
| GO:0070316 | 2.28991321124e-07 | 0.625 | PCGF6 RYBP YAF2 RNF2 RING1 | regulation of G0 to G1 transition |
| GO:0045023 | 3.00089323888e-07 | 0.625 | PCGF6 RYBP YAF2 RNF2 RING1 | G0 to G1 transition |
| REAC:R-HSA-8939243 | 3.54260492885e-07 | 0.5 | RING1 RNF2 YAF2 RYBP | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| GO:0000152 | 3.87822799753e-07 | 0.625 | PCGF6 RNF2 BCOR PCGF1 RING1 | nuclear ubiquitin ligase complex |
| GO:0016570 | 8.67623488902e-07 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | histone modification |
| GO:0016569 | 1.19224153963e-06 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | covalent chromatin modification |
| GO:0035102 | 2.32549003135e-06 | 0.5 | PCGF6 RNF2 PCGF1 RING1 | PRC1 complex |
| GO:0016567 | 4.4330337265e-05 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | protein ubiquitination |
| GO:0006325 | 5.19270313175e-05 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | chromatin organization |
| CORUM:1462 | 7.00904180673e-05 | 0.25 | RING1 RNF2 | hPRC1L complex |
| GO:0032446 | 0.000103172691785 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | protein modification by small protein conjugation |
| GO:0036353 | 0.00028444859377 | 0.375 | PCGF6 PCGF1 RNF2 | histone H2A-K119 monoubiquitination |
| CORUM:0000000 | 0.000356401437906 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | CORUM root |
| GO:0070647 | 0.000532319978735 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | protein modification by small protein conjugation or removal |
| REAC:R-HSA-8878171 | 0.00053900421153 | 0.5 | RING1 RNF2 YAF2 RYBP | Transcriptional regulation by RUNX1 |
| CORUM:115 | 0.000641288348151 | 0.25 | RING1 RNF2 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| CORUM:116 | 0.000769339286093 | 0.25 | RING1 RNF2 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| GO:0051172 | 0.000769497455075 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of nitrogen compound metabolic process |
| GO:0045892 | 0.000833989390095 | 0.875 | RING1 PCGF1 RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of transcription, DNA-templated |
| GO:1903507 | 0.000847508329733 | 0.875 | RING1 PCGF1 RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of nucleic acid-templated transcription |
| GO:1902679 | 0.0008543377534 | 0.875 | RING1 PCGF1 RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of RNA biosynthetic process |
| GO:0051276 | 0.00135023127082 | 0.875 | RING1 PCGF1 RYBP RNF2 PCGF6 BCOR KDM2B | chromosome organization |
| GO:0051253 | 0.00153219339021 | 0.875 | RING1 PCGF1 RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of RNA metabolic process |
| GO:0031324 | 0.00155173829498 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of cellular metabolic process |
| GO:0045934 | 0.00257183962514 | 0.875 | RING1 PCGF1 RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of nucleobase-containing compound metabolic process |
| GO:2000113 | 0.0025894672053 | 0.875 | RING1 PCGF1 RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of cellular macromolecule biosynthetic process |
| GO:0010558 | 0.00290532866326 | 0.875 | RING1 PCGF1 RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of macromolecule biosynthetic process |
| GO:0031327 | 0.00361323561696 | 0.875 | RING1 PCGF1 RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of cellular biosynthetic process |
| GO:0010605 | 0.00387642029018 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of macromolecule metabolic process |
| GO:0009890 | 0.00392999514621 | 0.875 | RING1 PCGF1 RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of biosynthetic process |
| GO:0000151 | 0.00394966069931 | 0.625 | PCGF6 RNF2 BCOR PCGF1 RING1 | ubiquitin ligase complex |
| REAC:R-HSA-4655427 | 0.00468368688758 | 0.25 | RING1 RNF2 | SUMOylation of DNA methylation proteins |
| GO:0010948 | 0.00673460397389 | 0.625 | PCGF6 RYBP YAF2 RNF2 RING1 | negative regulation of cell cycle process |
| GO:0006355 | 0.00757454699438 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | regulation of transcription, DNA-templated |
| CORUM:929 | 0.00771135052965 | 0.25 | RING1 RNF2 | CEN complex |
| GO:1903506 | 0.00775013880853 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | regulation of nucleic acid-templated transcription |
| GO:2001141 | 0.00783926269357 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | regulation of RNA biosynthetic process |
| GO:0009892 | 0.00786916927514 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of metabolic process |
| REAC:R-HSA-212436 | 0.0132859010078 | 0.625 | PCGF6 RYBP YAF2 RNF2 RING1 | Generic Transcription Pathway |
| GO:0006351 | 0.0145078913523 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | transcription, DNA-templated |
| GO:0097659 | 0.0148177261561 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | nucleic acid-templated transcription |
| GO:0032774 | 0.0151333353827 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | RNA biosynthetic process |
| GO:0051252 | 0.0178773875113 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | regulation of RNA metabolic process |
| REAC:R-HSA-73857 | 0.0224473446481 | 0.625 | PCGF6 RYBP YAF2 RNF2 RING1 | RNA Polymerase II Transcription |
| GO:2000112 | 0.0246985668667 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | regulation of cellular macromolecule biosynthetic process |
| GO:0010629 | 0.025164676983 | 0.875 | RING1 PCGF1 RNF2 PCGF6 YAF2 BCOR KDM2B | negative regulation of gene expression |
| GO:0010556 | 0.028892472479 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | regulation of macromolecule biosynthetic process |
| REAC:R-HSA-3899300 | 0.0345601208955 | 0.25 | RING1 RNF2 | SUMOylation of transcription cofactors |
| GO:0019219 | 0.0352235190624 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | regulation of nucleobase-containing compound metabolic process |
| REAC:R-HSA-74160 | 0.037866398773 | 0.625 | PCGF6 RYBP YAF2 RNF2 RING1 | Gene expression (Transcription) |
| GO:0031326 | 0.038100921268 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | regulation of cellular biosynthetic process |
| REAC:R-HSA-4570464 | 0.0381285523959 | 0.25 | RING1 RNF2 | SUMOylation of RNA binding proteins |
| GO:0009889 | 0.044342603266 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | regulation of biosynthetic process |
| GO:0034654 | 0.0465658023825 | 1.0 | RING1 PCGF1 RYBP RNF2 PCGF6 YAF2 BCOR KDM2B | nucleobase-containing compound biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RYBP | RNF2 | 1.0 | 0.949 | hein_WMM bioplex (RYBP) bioplex_WMM hein (RNF2) |
| RING1 | RYBP | 1.0 | 0.949 | hein_WMM bioplex (RYBP) bioplex_WMM hein (RING1) |
| PCGF1 | RYBP | 0.999 | 0.949 | hein_WMM bioplex (RYBP) bioplex_WMM hein (PCGF1) |
| RING1 | YAF2 | 0.892 | 0.819 | hein_WMM bioplex (YAF2) bioplex_WMM hein (RING1) |
| YAF2 | RNF2 | 0.888 | 0.818 | hein_WMM bioplex (YAF2) bioplex_WMM hein (RNF2) |
| BCOR | RYBP | 0.863 | 0.799 | hein_WMM bioplex (RYBP) bioplex_WMM |
| PCGF6 | RNF2 | 0.812 | 0.771 | hein_WMM bioplex (PCGF6) bioplex_WMM hein (RNF2) |
| KDM2B | RYBP | 0.772 | 0.751 | hein_WMM bioplex (RYBP) bioplex_WMM |
| PCGF6 | RYBP | 0.77 | 0.749 | hein_WMM bioplex (PCGF6,RYBP) bioplex_WMM |
| PCGF1 | YAF2 | 0.726 | 0.736 | hein_WMM bioplex (YAF2) bioplex_WMM hein (PCGF1) |
| PCGF6 | RING1 | 0.707 | 0.729 | hein_WMM bioplex (PCGF6) bioplex_WMM youn_WMM hein (RING1) gupta_WMM |
| RING1 | RNF2 | 0.551 | 0.644 | hein_WMM bioplex_WMM hein (RING1,RNF2) boldt_WMM |
| PCGF1 | KDM2B | 0.264 | 0.482 | hein_WMM bioplex_WMM youn_WMM hein (PCGF1) gupta_WMM |
| YAF2 | BCOR | 0.196 | 0.45 | hein_WMM bioplex (YAF2) bioplex_WMM hein (BCOR) |
| PCGF1 | BCOR | 0.144 | 0.407 | hein_WMM bioplex_WMM youn_WMM hein (BCOR,PCGF1) gupta_WMM |
| YAF2 | KDM2B | 0.141 | 0.405 | hein_WMM bioplex (YAF2) bioplex_WMM |
| YAF2 | RYBP | 0.133 | 0.405 | hein_WMM bioplex (YAF2) bioplex_WMM |
| PCGF6 | YAF2 | 0.093 | 0.355 | hein_WMM bioplex (PCGF6,YAF2) bioplex_WMM |
| RING1 | PCGF1 | 0.064 | 0.348 | hein_WMM bioplex_WMM youn_WMM hein (PCGF1,RING1) gupta_WMM |
| BCOR | KDM2B | 0.04 | 0.267 | hein_WMM bioplex_WMM youn_WMM hein (BCOR) gupta_WMM |
| RING1 | BCOR | 0.018 | 0.182 | hein_WMM bioplex_WMM youn_WMM hein (BCOR,RING1) gupta_WMM |
| PCGF1 | RNF2 | 0.017 | 0.166 | hein_WMM bioplex_WMM hein (PCGF1,RNF2) gupta_WMM |
| BCOR | RNF2 | 0.014 | 0.137 | hein_WMM bioplex_WMM hein (BCOR,RNF2) gupta_WMM |
| RING1 | KDM2B | 0.012 | 0.145 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PCGF6 | PCGF1 | 0.011 | 0.145 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| PCGF6 | KDM2B | 0.01 | 0.1 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| PCGF6 | BCOR | 0.008 | 0.051 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| KDM2B | RNF2 | 0.007 | 0.004 | hein_WMM bioplex_WMM hein (RNF2) gupta_WMM |
Images
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Complex HuMAP2_02200 has an average edge precision of 0.49 which is ranked 2553 out of all 6965 complexes.
Related Complexes