hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02221

Confidence: Medium High

Genename	Protein Name	Links
RBM8A	RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A)	UniProt NCBI
FAF1	FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)	UniProt NCBI
PYM1	Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog)	UniProt NCBI
MAGOHB	Protein mago nashi homolog 2	UniProt NCBI
CASC3	Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)	UniProt NCBI
SDE2	Replication stress response regulator SDE2	UniProt NCBI
MAGOH	Protein mago nashi homolog	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:755	4.54099480282e-12	0.571428571429	MAGOH CASC3 PYM1 RBM8A	Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14, PYM)
GO:0035145	1.99723678299e-09	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	exon-exon junction complex
KEGG:03015	6.99890529764e-09	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	mRNA surveillance pathway
CORUM:740	1.3523445861e-08	0.428571428571	MAGOH CASC3 RBM8A	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
CORUM:744	1.3523445861e-08	0.428571428571	MAGOH CASC3 RBM8A	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
CORUM:754	1.3523445861e-08	0.428571428571	MAGOH CASC3 RBM8A	Exon junction complex (EIF4A3, MLN51, UPF3B, MAGOH, Y14)
CORUM:769	1.3523445861e-08	0.428571428571	MAGOH CASC3 RBM8A	Exon junction complex (EIF4A3, MLN51, MAGOH, Y14)
KEGG:03013	1.15995464249e-07	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	RNA transport
REAC:R-HSA-72187	8.95849477501e-07	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	mRNA 3'-end processing
REAC:R-HSA-73856	1.68489749807e-06	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	RNA Polymerase II Transcription Termination
REAC:R-HSA-159236	2.30170723977e-06	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	Transport of Mature mRNA derived from an Intron-Containing Transcript
REAC:R-HSA-72202	3.81921586265e-06	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	Transport of Mature Transcript to Cytoplasm
CORUM:773	1.007158685e-05	0.285714285714	MAGOH RBM8A	Y14-Magoh complex
CORUM:763	1.007158685e-05	0.285714285714	MAGOH RBM8A	Y14-Magoh complex
REAC:R-HSA-927802	1.80658141094e-05	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	Nonsense-Mediated Decay (NMD)
REAC:R-HSA-975957	1.80658141094e-05	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GO:0000184	2.38559538933e-05	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
CORUM:1293	3.02079974644e-05	0.285714285714	MAGOH RBM8A	IPO13-RBM8A-MAGOH complex
REAC:R-HSA-9010553	8.90403607787e-05	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	Regulation of expression of SLITs and ROBOs
REAC:R-HSA-72163	0.000112255388571	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	mRNA Splicing - Major Pathway
REAC:R-HSA-72172	0.000133860306432	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	mRNA Splicing
CORUM:6742	0.000150938581911	0.285714285714	MAGOH RBM8A	SMG1-UPF2-Y14-MAGOH-UPF3B-EIF4A3 complex
CORUM:785	0.000211266711219	0.285714285714	MAGOH RBM8A	Exon junction complex
REAC:R-HSA-376176	0.000230147875754	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	Signaling by ROBO receptors
REAC:R-HSA-72203	0.000340690824707	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	Processing of Capped Intron-Containing Pre-mRNA
GO:0000956	0.000395509369864	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	nuclear-transcribed mRNA catabolic process
GO:0071012	0.000698035893352	0.428571428571	MAGOHB CASC3 RBM8A	catalytic step 1 spliceosome
GO:0071006	0.000698035893352	0.428571428571	MAGOHB CASC3 RBM8A	U2-type catalytic step 1 spliceosome
KEGG:03040	0.00116183627381	0.428571428571	MAGOHB RBM8A MAGOH	Spliceosome
GO:0031124	0.00245741336962	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	mRNA 3'-end processing
GO:0071427	0.00433362278423	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	mRNA-containing ribonucleoprotein complex export from nucleus
GO:0006406	0.00433362278423	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	mRNA export from nucleus
GO:0051028	0.00521131302174	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	mRNA transport
GO:0006402	0.00582560339799	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	mRNA catabolic process
GO:0071426	0.00735794310123	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	ribonucleoprotein complex export from nucleus
REAC:R-HSA-422475	0.00749530493622	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	Axon guidance
GO:0071166	0.00760403592695	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	ribonucleoprotein complex localization
GO:0006401	0.00891451540705	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	RNA catabolic process
GO:0006405	0.009800844161	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	RNA export from nucleus
GO:0031123	0.0107359250842	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	RNA 3'-end processing
GO:0050657	0.0168953290765	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	nucleic acid transport
GO:0050658	0.0168953290765	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	RNA transport
GO:0051236	0.0182937084766	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	establishment of RNA localization
REAC:R-HSA-8953854	0.0191594284188	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	Metabolism of RNA
GO:0006611	0.0208141612097	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	protein export from nucleus
GO:0005681	0.0224457600324	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	spliceosomal complex
GO:0044265	0.024558499611	0.857142857143	PYM1 MAGOH MAGOHB CASC3 RBM8A FAF1	cellular macromolecule catabolic process
GO:0034655	0.0271422741221	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	nucleobase-containing compound catabolic process
GO:0051168	0.0279164723718	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	nuclear export
CORUM:1181	0.0297343384587	0.285714285714	MAGOH RBM8A	C complex spliceosome
GO:0015931	0.0299438047992	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	nucleobase-containing compound transport
GO:0046700	0.0390972199184	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	heterocycle catabolic process
GO:0044270	0.0394916293115	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	cellular nitrogen compound catabolic process
GO:0006403	0.0400242316232	0.571428571429	MAGOHB CASC3 RBM8A MAGOH	RNA localization
GO:0019439	0.0444762556298	0.714285714286	MAGOHB PYM1 CASC3 RBM8A MAGOH	aromatic compound catabolic process
CORUM:772	0.0499886427319	0.142857142857	CASC3	EIF4A3-MLN51 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
MAGOH	RBM8A	1.0	0.949	hein_WMM bioplex (MAGOH) bioplex_WMM youn_WMM hein (MAGOH,RBM8A) gupta_WMM treiber_WMM
MAGOH	PYM1	1.0	0.949	hein_WMM bioplex (MAGOH,PYM1) bioplex_WMM youn_WMM hein (MAGOH)
RBM8A	PYM1	0.384	0.55	hein_WMM bioplex (PYM1) bioplex_WMM youn_WMM hein (RBM8A) gupta_WMM
MAGOHB	RBM8A	0.344	0.534	hein_WMM hein (MAGOHB,RBM8A) gupta_WMM
MAGOHB	MAGOH	0.254	0.478	hein_WMM hein (MAGOH) gupta_WMM
SDE2	RBM8A	0.159	0.416	hein_WMM bioplex_WMM youn_WMM hein (RBM8A) gupta_WMM
MAGOHB	FAF1	0.114	0.385	fraction
MAGOH	FAF1	0.102	0.366	bioplex_WMM fraction
CASC3	MAGOH	0.053	0.3	hein_WMM bioplex (MAGOH) bioplex_WMM youn_WMM
CASC3	RBM8A	0.052	0.301	hein_WMM bioplex_WMM youn_WMM hein (RBM8A)
CASC3	PYM1	0.013	0.152	hein_WMM bioplex (PYM1) bioplex_WMM youn_WMM
FAF1	PYM1	0.007	0.005	bioplex_WMM WMM_only
MAGOHB	SDE2	0.007	0.005	hein_WMM WMM_only
SDE2	MAGOH	0.007	0.006	hein_WMM bioplex_WMM youn_WMM WMM_only
SDE2	PYM1	0.007	0.002	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
SDE2	FAF1	0.007	0.0	bioplex_WMM WMM_only
MAGOHB	CASC3	0.007	0.004	hein_WMM WMM_only
RBM8A	FAF1	0.007	0.004	bioplex_WMM WMM_only
CASC3	SDE2	0.006	0.002	hein_WMM bioplex_WMM youn_WMM WMM_only
MAGOHB	PYM1	0.004	0.012	hein_WMM hein (MAGOHB)

Images

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Complex HuMAP2_02221 has an average edge precision of 0.271 which is ranked 5006 out of all 6965 complexes.

Related Complexes

Genename	Complexes
RBM8A	HuMAP2_00752 HuMAP2_02221 HuMAP2_02922 HuMAP2_03053 HuMAP2_03472
FAF1	HuMAP2_00752 HuMAP2_01968 HuMAP2_02221 HuMAP2_03053 HuMAP2_06881
PYM1	HuMAP2_00752 HuMAP2_01153 HuMAP2_02097 HuMAP2_02221 HuMAP2_02422 HuMAP2_03053 HuMAP2_03472 HuMAP2_05786
MAGOHB	HuMAP2_00752 HuMAP2_02221 HuMAP2_02922 HuMAP2_03053
CASC3	HuMAP2_00752 HuMAP2_02221 HuMAP2_03053 HuMAP2_06651
SDE2	HuMAP2_00752 HuMAP2_01387 HuMAP2_02221 HuMAP2_04055
MAGOH	HuMAP2_00752 HuMAP2_02221 HuMAP2_02422 HuMAP2_03053 HuMAP2_03472

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02221