hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02228
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CCND1 | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) | UniProt NCBI |
| WDR45B | WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein) | UniProt NCBI |
| GAS2L1 | GAS2-like protein 1 (GAS2-related protein on chromosome 22) (Growth arrest-specific protein 2-like 1) | UniProt NCBI |
| FAM114A1 | Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1) | UniProt NCBI |
| CDKN2C | Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6) | UniProt NCBI |
| MAPRE3 | Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3998 | 0.00524729006009 | 0.333333333333 | CCND1 CDKN2C | Prader-Willi and Angelman Syndrome |
| WP:WP45 | 0.0107960863784 | 0.333333333333 | CCND1 CDKN2C | G1 to S cell cycle control |
| WP:WP2261 | 0.0182958407223 | 0.333333333333 | CCND1 CDKN2C | Signaling Pathways in Glioblastoma |
| REAC:R-HSA-69231 | 0.0189534530409 | 0.333333333333 | CCND1 CDKN2C | Cyclin D associated events in G1 |
| REAC:R-HSA-69236 | 0.0189534530409 | 0.333333333333 | CCND1 CDKN2C | G1 Phase |
| KEGG:01522 | 0.0246844798555 | 0.333333333333 | CCND1 CDKN2C | Endocrine resistance |
| HP:0100634 | 0.0262553193116 | 0.333333333333 | CCND1 CDKN2C | Neuroendocrine neoplasm |
| WP:WP179 | 0.0365222779269 | 0.333333333333 | CCND1 CDKN2C | Cell Cycle |
| GO:1904825 | 0.0405595771497 | 0.333333333333 | MAPRE3 GAS2L1 | protein localization to microtubule plus-end |
| GO:1905725 | 0.0405595771497 | 0.333333333333 | MAPRE3 GAS2L1 | protein localization to microtubule end |
| WP:WP2877 | 0.0437238028604 | 0.333333333333 | CCND1 CDKN2C | Vitamin D Receptor Pathway |
| KEGG:04110 | 0.0437703225478 | 0.333333333333 | CCND1 CDKN2C | Cell cycle |
| CORUM:2635 | 0.0499726005494 | 0.166666666667 | CCND1 | BETA2-Cyclin D1 complex |
| CORUM:3084 | 0.0499726005494 | 0.166666666667 | CCND1 | CCND1-CDK4 complex |
| CORUM:3087 | 0.0499726005494 | 0.166666666667 | CCND1 | CCND1-CDK6 complex |
| CORUM:5287 | 0.0499726005494 | 0.166666666667 | CCND1 | CCND1-CDK4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAPRE3 | GAS2L1 | 1.0 | 0.949 | bioplex (GAS2L1) bioplex_WMM |
| WDR45B | GAS2L1 | 0.047 | 0.293 | bioplex (GAS2L1) bioplex_WMM |
| CDKN2C | CCND1 | 0.035 | 0.261 | bioplex (CCND1) bioplex_WMM |
| CDKN2C | GAS2L1 | 0.031 | 0.24 | bioplex (GAS2L1) bioplex_WMM |
| FAM114A1 | MAPRE3 | 0.029 | 0.233 | fraction |
| CDKN2C | MAPRE3 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| WDR45B | MAPRE3 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| CDKN2C | WDR45B | 0.006 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02228 has an average edge precision of 0.248 which is ranked 5405 out of all 6965 complexes.
Related Complexes