hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02230
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| REV3L | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | UniProt NCBI |
| POLD4 | DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) | UniProt NCBI |
| POLD3 | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | UniProt NCBI |
| AMZ1 | Archaemetzincin-1 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 1) | UniProt NCBI |
| POLD2 | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:297 | 1.35119464053e-08 | 0.6 | POLD4 POLD2 POLD3 | PCNA-DNA polymerase delta complex |
| REAC:R-HSA-110313 | 2.69082165127e-08 | 0.8 | POLD4 POLD3 POLD2 REV3L | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-73893 | 6.49889456043e-08 | 0.8 | POLD4 POLD3 POLD2 REV3L | DNA Damage Bypass |
| WP:WP186 | 1.47866495656e-07 | 0.6 | POLD4 POLD2 POLD3 | Homologous recombination |
| CORUM:1107 | 1.62061692851e-07 | 0.6 | POLD4 POLD2 POLD3 | DNA synthesome core complex |
| GO:0042575 | 2.21856478938e-07 | 0.8 | POLD4 POLD3 POLD2 REV3L | DNA polymerase complex |
| REAC:R-HSA-174437 | 3.26064244298e-07 | 0.6 | POLD4 POLD2 POLD3 | Removal of the Flap Intermediate from the C-strand |
| CORUM:1098 | 3.86130280192e-07 | 0.6 | POLD4 POLD2 POLD3 | DNA synthesome complex (13 subunits) |
| REAC:R-HSA-174414 | 4.48293159034e-07 | 0.6 | POLD4 POLD2 POLD3 | Processive synthesis on the C-strand of the telomere |
| CORUM:1108 | 6.14174359209e-07 | 0.6 | POLD4 POLD2 POLD3 | DNA synthesome complex (15 subunits) |
| GO:0003887 | 8.91404751529e-07 | 0.8 | POLD4 POLD3 POLD2 REV3L | DNA-directed DNA polymerase activity |
| CORUM:1111 | 9.17701933879e-07 | 0.6 | POLD4 POLD2 POLD3 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 9.17701933879e-07 | 0.6 | POLD4 POLD2 POLD3 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-5358606 | 9.88662921473e-07 | 0.6 | POLD4 POLD2 POLD3 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-69091 | 9.88662921473e-07 | 0.6 | POLD4 POLD2 POLD3 | Polymerase switching |
| REAC:R-HSA-174411 | 9.88662921473e-07 | 0.6 | POLD4 POLD2 POLD3 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-69109 | 9.88662921473e-07 | 0.6 | POLD4 POLD2 POLD3 | Leading Strand Synthesis |
| REAC:R-HSA-69166 | 9.88662921473e-07 | 0.6 | POLD4 POLD2 POLD3 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358565 | 9.88662921473e-07 | 0.6 | POLD4 POLD2 POLD3 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-69183 | 1.23570409997e-06 | 0.6 | POLD4 POLD2 POLD3 | Processive synthesis on the lagging strand |
| REAC:R-HSA-5358508 | 1.23570409997e-06 | 0.6 | POLD4 POLD2 POLD3 | Mismatch Repair |
| KEGG:03430 | 1.52872218556e-06 | 0.6 | POLD4 POLD2 POLD3 | Mismatch repair |
| GO:0034061 | 2.49427518271e-06 | 0.8 | POLD4 POLD3 POLD2 REV3L | DNA polymerase activity |
| REAC:R-HSA-69186 | 3.09448976434e-06 | 0.6 | POLD4 POLD2 POLD3 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 3.60987410111e-06 | 0.6 | POLD4 POLD2 POLD3 | PCNA-Dependent Long Patch Base Excision Repair |
| GO:0016035 | 3.6323771075e-06 | 0.6 | REV3L POLD2 POLD3 | zeta DNA polymerase complex |
| GO:0043625 | 3.6323771075e-06 | 0.6 | POLD4 POLD2 POLD3 | delta DNA polymerase complex |
| KEGG:03410 | 4.27757362181e-06 | 0.6 | POLD4 POLD2 POLD3 | Base excision repair |
| REAC:R-HSA-174417 | 5.49186125546e-06 | 0.6 | POLD4 POLD2 POLD3 | Telomere C-strand (Lagging Strand) Synthesis |
| KEGG:03030 | 6.15515195207e-06 | 0.6 | POLD4 POLD2 POLD3 | DNA replication |
| REAC:R-HSA-5696397 | 6.24012216224e-06 | 0.6 | POLD4 POLD2 POLD3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-110373 | 6.24012216224e-06 | 0.6 | POLD4 POLD2 POLD3 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| WP:WP466 | 7.69263363807e-06 | 0.6 | POLD4 POLD2 POLD3 | DNA Replication |
| KEGG:03440 | 8.5137761885e-06 | 0.6 | POLD4 POLD2 POLD3 | Homologous recombination |
| REAC:R-HSA-110314 | 1.10096191184e-05 | 0.6 | POLD4 POLD2 POLD3 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 1.10096191184e-05 | 0.6 | POLD4 POLD2 POLD3 | Extension of Telomeres |
| GO:0019985 | 1.11259903434e-05 | 0.8 | POLD4 POLD3 POLD2 REV3L | translesion synthesis |
| KEGG:03420 | 1.14079902474e-05 | 0.6 | POLD4 POLD2 POLD3 | Nucleotide excision repair |
| REAC:R-HSA-5656169 | 1.21879917622e-05 | 0.6 | POLD4 POLD2 POLD3 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 1.34474619847e-05 | 0.6 | POLD4 POLD2 POLD3 | DNA strand elongation |
| REAC:R-HSA-73933 | 1.77393158174e-05 | 0.6 | POLD4 POLD2 POLD3 | Resolution of Abasic Sites (AP sites) |
| GO:0000731 | 1.98600319243e-05 | 0.8 | POLD4 POLD3 POLD2 REV3L | DNA synthesis involved in DNA repair |
| GO:0006301 | 2.802206198e-05 | 0.8 | POLD4 POLD3 POLD2 REV3L | postreplication repair |
| REAC:R-HSA-5696400 | 2.88749669481e-05 | 0.6 | POLD4 POLD2 POLD3 | Dual Incision in GG-NER |
| WP:WP4022 | 5.27923808575e-05 | 0.6 | POLD4 POLD2 POLD3 | Pyrimidine metabolism |
| REAC:R-HSA-6782210 | 0.000112594374126 | 0.6 | POLD4 POLD2 POLD3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-5685942 | 0.000118030564163 | 0.6 | POLD4 POLD2 POLD3 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-6782135 | 0.000118030564163 | 0.6 | POLD4 POLD2 POLD3 | Dual incision in TC-NER |
| REAC:R-HSA-73894 | 0.00015586029631 | 0.8 | POLD4 POLD3 POLD2 REV3L | DNA Repair |
| REAC:R-HSA-6781827 | 0.000205300002873 | 0.6 | POLD4 POLD2 POLD3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 0.00023017619861 | 0.6 | POLD4 POLD2 POLD3 | Telomere Maintenance |
| REAC:R-HSA-5696399 | 0.00025697910325 | 0.6 | POLD4 POLD2 POLD3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-73884 | 0.000285779749786 | 0.6 | POLD4 POLD2 POLD3 | Base Excision Repair |
| REAC:R-HSA-73886 | 0.000549269398166 | 0.6 | POLD4 POLD2 POLD3 | Chromosome Maintenance |
| REAC:R-HSA-5696398 | 0.000580533129267 | 0.6 | POLD4 POLD2 POLD3 | Nucleotide Excision Repair |
| REAC:R-HSA-69239 | 0.000717394603045 | 0.6 | POLD4 POLD2 POLD3 | Synthesis of DNA |
| GO:0016779 | 0.000726326030407 | 0.8 | POLD4 POLD3 POLD2 REV3L | nucleotidyltransferase activity |
| REAC:R-HSA-69306 | 0.000874143100407 | 0.6 | POLD4 POLD2 POLD3 | DNA Replication |
| REAC:R-HSA-5693567 | 0.000960389260783 | 0.6 | POLD4 POLD2 POLD3 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.00110006319269 | 0.6 | POLD4 POLD2 POLD3 | Homology Directed Repair |
| GO:0006261 | 0.00125226429768 | 0.8 | POLD4 POLD3 POLD2 REV3L | DNA-dependent DNA replication |
| GO:0006297 | 0.00160515829483 | 0.6 | POLD4 POLD2 POLD3 | nucleotide-excision repair, DNA gap filling |
| REAC:R-HSA-69242 | 0.00175946619988 | 0.6 | POLD4 POLD2 POLD3 | S Phase |
| REAC:R-HSA-5693532 | 0.00193087050228 | 0.6 | POLD4 POLD2 POLD3 | DNA Double-Strand Break Repair |
| GO:0071897 | 0.00202202063273 | 0.8 | POLD4 POLD3 POLD2 REV3L | DNA biosynthetic process |
| GO:0043601 | 0.00208420080219 | 0.6 | POLD4 POLD2 POLD3 | nuclear replisome |
| GO:0030894 | 0.00265002518516 | 0.6 | POLD4 POLD2 POLD3 | replisome |
| GO:0032201 | 0.00265002518516 | 0.6 | POLD4 POLD2 POLD3 | telomere maintenance via semi-conservative replication |
| GO:0006298 | 0.00407078924856 | 0.6 | POLD4 POLD2 POLD3 | mismatch repair |
| GO:0140097 | 0.00456271095818 | 0.8 | POLD4 POLD3 POLD2 REV3L | catalytic activity, acting on DNA |
| GO:0042769 | 0.00646290954968 | 0.6 | POLD4 POLD2 POLD3 | DNA damage response, detection of DNA damage |
| GO:0006296 | 0.00703245670927 | 0.6 | POLD4 POLD2 POLD3 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| GO:0033683 | 0.00826983957236 | 0.6 | POLD4 POLD2 POLD3 | nucleotide-excision repair, DNA incision |
| GO:0006260 | 0.00913982817851 | 0.8 | POLD4 POLD3 POLD2 REV3L | DNA replication |
| GO:0043596 | 0.00964423896068 | 0.6 | POLD4 POLD2 POLD3 | nuclear replication fork |
| GO:0061695 | 0.0120893245383 | 0.8 | POLD4 POLD3 POLD2 REV3L | transferase complex, transferring phosphorus-containing groups |
| GO:0033260 | 0.0199719657189 | 0.6 | POLD4 POLD2 POLD3 | nuclear DNA replication |
| GO:0044786 | 0.0250406933376 | 0.6 | POLD4 POLD2 POLD3 | cell cycle DNA replication |
| GO:0005657 | 0.0376065209581 | 0.6 | POLD4 POLD2 POLD3 | replication fork |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLD2 | POLD4 | 0.956 | 0.862 | hein_WMM bioplex (POLD2) bioplex_WMM |
| POLD2 | REV3L | 0.454 | 0.595 | bioplex (POLD2) bioplex_WMM |
| POLD2 | POLD3 | 0.061 | 0.336 | hein_WMM bioplex (POLD2) bioplex_WMM youn_WMM fraction |
| AMZ1 | POLD2 | 0.06 | 0.337 | bioplex (AMZ1) bioplex_WMM |
| POLD4 | REV3L | 0.009 | 0.095 | bioplex_WMM WMM_only |
| POLD4 | POLD3 | 0.009 | 0.093 | hein_WMM bioplex_WMM WMM_only |
| REV3L | POLD3 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| AMZ1 | POLD3 | 0.004 | 0.009 | bioplex (AMZ1) bioplex_WMM |
Images
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Complex HuMAP2_02230 has an average edge precision of 0.291 which is ranked 4733 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| REV3L | HuMAP2_02230 HuMAP2_05209 HuMAP2_06286 |
| POLD4 | HuMAP2_02230 HuMAP2_05209 HuMAP2_05819 HuMAP2_06286 |
| POLD3 | HuMAP2_02230 HuMAP2_05209 HuMAP2_06286 |
| AMZ1 | HuMAP2_00378 HuMAP2_02230 HuMAP2_06286 HuMAP2_06838 |
| POLD2 | HuMAP2_02230 HuMAP2_05209 HuMAP2_05819 HuMAP2_06286 |