hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02234
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BBS9 | Protein PTHB1 (Bardet-Biedl syndrome 9 protein) (Parathyroid hormone-responsive B1 gene protein) | UniProt NCBI |
| BBS1 | Bardet-Biedl syndrome 1 protein (BBS2-like protein 2) | UniProt NCBI |
| BBS7 | Bardet-Biedl syndrome 7 protein (BBS2-like protein 1) | UniProt NCBI |
| TTC8 | Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein) | UniProt NCBI |
| BBS4 | Bardet-Biedl syndrome 4 protein | UniProt NCBI |
| BBS2 | Bardet-Biedl syndrome 2 protein | UniProt NCBI |
| BBS5 | Bardet-Biedl syndrome 5 protein | UniProt NCBI |
| LZTFL1 | Leucine zipper transcription factor-like protein 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6163 | 9.19738178297e-23 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | BBSome |
| REAC:R-HSA-5620922 | 6.01880516365e-22 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | BBSome-mediated cargo-targeting to cilium |
| HP:0010747 | 1.18702364332e-20 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Medial flaring of the eyebrow |
| GO:0034464 | 9.93317232561e-20 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | BBSome |
| REAC:R-HSA-5620920 | 9.30098970296e-19 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Cargo trafficking to the periciliary membrane |
| HP:0008724 | 9.72735143081e-18 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Hypoplasia of the ovary |
| HP:0010462 | 1.33627353143e-17 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Aplasia/Hypoplasia of the ovary |
| WP:WP4536 | 2.00725182405e-16 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Genes related to primary cilium development (based on CRISPR) |
| HP:0001162 | 6.41305658625e-16 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Postaxial hand polydactyly |
| HP:0000003 | 1.33401594646e-15 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Multicystic kidney dysplasia |
| HP:0031065 | 1.87892168224e-15 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal ovarian morphology |
| HP:0001395 | 1.87892168224e-15 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Hepatic fibrosis |
| HP:0002230 | 1.87892168224e-15 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Generalized hirsutism |
| HP:0000100 | 3.86346527163e-15 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Nephrotic syndrome |
| HP:0100259 | 6.97238748462e-15 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Postaxial polydactyly |
| WP:WP4656 | 2.03982344287e-14 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | Joubert Syndrome |
| HP:0000580 | 3.47393175942e-14 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Pigmentary retinopathy |
| HP:0000512 | 5.4620447786e-14 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal electroretinogram |
| HP:0001161 | 6.43102468474e-14 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Hand polydactyly |
| WP:WP4352 | 7.47442024769e-14 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Ciliary landscape |
| HP:0001007 | 8.82933364768e-14 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Hirsutism |
| HP:0000426 | 1.02981436472e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Prominent nasal bridge |
| HP:0006101 | 1.08331121483e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Finger syndactyly |
| REAC:R-HSA-5617833 | 1.1199468523e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Cilium Assembly |
| HP:0009997 | 1.94251102903e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Duplication of phalanx of hand |
| HP:0004275 | 2.03556544959e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Duplication of hand bones |
| HP:0009142 | 2.03556544959e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Duplication of bones involving the upper extremities |
| HP:0000137 | 3.20345293764e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the ovary |
| HP:0030453 | 3.4970340869e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal visual electrophysiology |
| HP:0000368 | 4.92021075924e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Low-set, posteriorly rotated ears |
| HP:0010442 | 6.2977463413e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Polydactyly |
| HP:0000107 | 8.0016077982e-13 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Renal cyst |
| CORUM:6165 | 1.58119379133e-12 | 0.5 | BBS9 BBS7 BBS2 BBS1 | BBSome core complex |
| REAC:R-HSA-1852241 | 2.43388104095e-12 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Organelle biogenesis and maintenance |
| HP:0000556 | 2.75441526558e-12 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Retinal dystrophy |
| HP:0000470 | 3.70909098624e-12 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Short neck |
| HP:0000822 | 4.08601621822e-12 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Hypertension |
| HP:0007703 | 7.35038370508e-12 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of retinal pigmentation |
| CORUM:6601 | 7.90426989013e-12 | 0.5 | BBS4 BBS5 TTC8 BBS1 | BBS1-BBS4-BBS5-PKD1-TTC8 complex |
| HP:0003319 | 9.03097965195e-12 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the cervical spine |
| HP:0032263 | 1.01349112763e-11 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Increased blood pressure |
| HP:0000135 | 1.45808406801e-11 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Hypogonadism |
| HP:0000358 | 1.58211350122e-11 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Posteriorly rotated ears |
| HP:0001159 | 1.58211350122e-11 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Syndactyly |
| HP:0001513 | 2.01132482597e-11 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Obesity |
| HP:0004207 | 2.67168644484e-11 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal 5th finger morphology |
| HP:0000510 | 3.0632300659e-11 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | Rod-cone dystrophy |
| HP:0030972 | 3.8740963513e-11 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal systemic blood pressure |
| GO:0001103 | 4.37916014478e-11 | 0.75 | BBS4 BBS5 BBS2 BBS7 BBS1 TTC8 | RNA polymerase II repressing transcription factor binding |
| HP:0004324 | 4.58133819178e-11 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Increased body weight |
| HP:0008736 | 4.91745585392e-11 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Hypoplasia of penis |
| HP:0000494 | 5.65499404899e-11 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Downslanted palpebral fissures |
| HP:0000534 | 1.32744303482e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal eyebrow morphology |
| HP:0000050 | 1.5329934252e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Hypoplastic male external genitalia |
| HP:0003202 | 1.98954426972e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Skeletal muscle atrophy |
| HP:0000464 | 2.23762373948e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the neck |
| HP:0003241 | 2.23762373948e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | External genital hypoplasia |
| HP:0000008 | 2.81616872455e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of female internal genitalia |
| HP:0000080 | 3.27099305689e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of reproductive system physiology |
| HP:0000812 | 5.04365414468e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal internal genitalia |
| HP:0011362 | 5.89828402202e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal hair quantity |
| HP:0010460 | 7.47993646755e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the female genitalia |
| HP:0200006 | 8.82593106025e-10 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Slanting of the palpebral fissure |
| HP:0005918 | 1.14218311799e-09 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal finger phalanx morphology |
| HP:0012211 | 1.16042157097e-09 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal renal physiology |
| HP:0030236 | 1.31574340178e-09 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of muscle size |
| HP:0008373 | 1.42179953219e-09 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Puberty and gonadal disorders |
| HP:0000036 | 1.46627156392e-09 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the penis |
| HP:0000369 | 1.55888110541e-09 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Low-set ears |
| HP:0000028 | 1.68181178596e-09 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Cryptorchidism |
| HP:0000357 | 2.50365282048e-09 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal location of ears |
| HP:0008050 | 2.61368832521e-09 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the palpebral fissures |
| GO:0070491 | 5.09995812676e-09 | 0.75 | BBS4 BBS5 BBS2 BBS7 BBS1 TTC8 | repressing transcription factor binding |
| HP:0410042 | 8.20408762047e-09 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal liver morphology |
| HP:0000479 | 1.1118652998e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal retinal morphology |
| HP:0000035 | 1.1940009842e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal testis morphology |
| HP:0000422 | 1.89057538073e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the nasal bridge |
| HP:0012210 | 1.95483890768e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal renal morphology |
| HP:0000639 | 2.85851277613e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Nystagmus |
| HP:0012547 | 3.17604406381e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal involuntary eye movements |
| HP:0011277 | 3.34607596652e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the urinary system physiology |
| HP:0001392 | 4.32134529392e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the liver |
| HP:0000032 | 4.32134529392e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of male external genitalia |
| HP:0001167 | 5.48299768108e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of finger |
| HP:0010461 | 5.64584867521e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the male genitalia |
| HP:0000811 | 5.70106479917e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal external genitalia |
| HP:0000356 | 6.1009866372e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the outer ear |
| HP:0001595 | 7.66474815312e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal hair morphology |
| HP:0002167 | 8.65004954732e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Neurological speech impairment |
| HP:0000492 | 9.65616137059e-08 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal eyelid morphology |
| HP:0011025 | 1.20863812217e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal cardiovascular system physiology |
| GO:0036064 | 1.2309433714e-07 | 0.75 | BBS4 BBS5 BBS2 BBS7 BBS1 TTC8 | ciliary basal body |
| HP:0001098 | 1.54288859464e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal fundus morphology |
| HP:0004329 | 1.58309219559e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal posterior eye segment morphology |
| HP:0002012 | 1.61040110703e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the abdominal organs |
| HP:0000077 | 1.7238031906e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the kidney |
| HP:0011138 | 2.07246549785e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of skin adnexa morphology |
| HP:0010935 | 2.15980718704e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the upper urinary tract |
| HP:0004322 | 2.32516353361e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Short stature |
| HP:0000818 | 2.32516353361e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the endocrine system |
| HP:0011297 | 2.66794132806e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal digit morphology |
| HP:0012243 | 3.0063086357e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal reproductive system morphology |
| HP:0030669 | 3.27775339183e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal ocular adnexa morphology |
| HP:0032039 | 3.71081851453e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the ocular adnexa |
| HP:0000925 | 3.85603884789e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the vertebral column |
| HP:0001155 | 3.85603884789e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the hand |
| HP:0000002 | 4.00620776936e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of body height |
| HP:0000315 | 4.25713143372e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the orbital region |
| HP:0000365 | 4.87256497185e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Hearing impairment |
| HP:0000364 | 5.40371454456e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Hearing abnormality |
| HP:0031704 | 5.40371454456e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal ear physiology |
| HP:0002817 | 7.41732490364e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the upper limb |
| HP:0000078 | 7.57583775496e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the genital system |
| GO:0060271 | 7.77827354513e-07 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | cilium assembly |
| HP:0040068 | 8.0693026288e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of limb bone |
| HP:0002813 | 8.0693026288e-07 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of limb bone morphology |
| GO:0044441 | 9.45716068527e-07 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | ciliary part |
| GO:0044782 | 1.12010141249e-06 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | cilium organization |
| HP:0000496 | 1.12061179621e-06 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of eye movement |
| HP:0000366 | 1.16648158045e-06 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the nose |
| HP:0004323 | 1.21398591396e-06 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of body weight |
| HP:0011844 | 1.45877879651e-06 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal appendicular skeleton morphology |
| HP:0001510 | 1.94304332775e-06 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Growth delay |
| HP:0011805 | 2.24093985781e-06 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal skeletal muscle morphology |
| HP:0000079 | 3.98269737856e-06 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the urinary system |
| GO:0005929 | 4.1532167841e-06 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | cilium |
| HP:0000546 | 4.82422687871e-06 | 0.625 | BBS4 BBS2 LZTFL1 TTC8 BBS1 | Retinal degeneration |
| HP:0031703 | 4.82652773778e-06 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal ear morphology |
| HP:0001249 | 4.82652773778e-06 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Intellectual disability |
| GO:0051904 | 5.20982418286e-06 | 0.5 | BBS4 BBS7 BBS5 BBS2 | pigment granule transport |
| GO:0032402 | 5.20982418286e-06 | 0.5 | BBS4 BBS7 BBS5 BBS2 | melanosome transport |
| GO:0051905 | 6.59769148731e-06 | 0.5 | BBS4 BBS7 BBS5 BBS2 | establishment of pigment granule localization |
| GO:0032401 | 6.59769148731e-06 | 0.5 | BBS4 BBS7 BBS5 BBS2 | establishment of melanosome localization |
| GO:0120031 | 8.16326008913e-06 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | plasma membrane bounded cell projection assembly |
| GO:0030031 | 9.38935094752e-06 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | cell projection assembly |
| GO:0051875 | 1.01832303085e-05 | 0.5 | BBS4 BBS7 BBS5 BBS2 | pigment granule localization |
| GO:0032400 | 1.01832303085e-05 | 0.5 | BBS4 BBS7 BBS5 BBS2 | melanosome localization |
| HP:0040064 | 1.08694745139e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of limbs |
| HP:0000598 | 1.09796490457e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the ear |
| GO:0061629 | 1.47806290067e-05 | 0.75 | BBS4 BBS5 BBS2 BBS7 BBS1 TTC8 | RNA polymerase II-specific DNA-binding transcription factor binding |
| HP:0012372 | 2.11918776221e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal eye morphology |
| HP:0012373 | 2.5461441355e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal eye physiology |
| HP:0001574 | 3.34218439818e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the integument |
| HP:0000119 | 3.49157378764e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the genitourinary system |
| CORUM:6166 | 3.50546248845e-05 | 0.25 | BBS4 TTC8 | BBSome linker complex |
| HP:0001507 | 3.61525962847e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Growth abnormality |
| HP:0001626 | 3.95835513997e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the cardiovascular system |
| HP:0009121 | 4.27477647448e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormal axial skeleton morphology |
| HP:0011446 | 4.97465201121e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of higher mental function |
| GO:0005815 | 6.27827537999e-05 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | microtubule organizing center |
| GO:0140297 | 6.31680158918e-05 | 0.75 | BBS4 BBS5 BBS2 BBS7 BBS1 TTC8 | DNA-binding transcription factor binding |
| HP:0012759 | 6.68084582198e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Neurodevelopmental abnormality |
| HP:0025031 | 7.8650944848e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the digestive system |
| HP:0003011 | 8.60672051559e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the musculature |
| HP:0000271 | 8.98254007768e-05 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the face |
| HP:0000478 | 0.000137576922914 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the eye |
| HP:0011842 | 0.000148016928202 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of skeletal morphology |
| HP:0000007 | 0.000149098080042 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Autosomal recessive inheritance |
| GO:0070925 | 0.000149537629199 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | organelle assembly |
| HP:0000924 | 0.000193602773605 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the skeletal system |
| HP:0000234 | 0.000197730066454 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the head |
| HP:0000152 | 0.000208386906503 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of head or neck |
| GO:0061512 | 0.000208985203536 | 0.5 | BBS9 LZTFL1 BBS1 BBS4 | protein localization to cilium |
| GO:0033059 | 0.000208985203536 | 0.5 | BBS4 BBS7 BBS5 BBS2 | cellular pigmentation |
| GO:0044463 | 0.00039496102155 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | cell projection part |
| GO:0120038 | 0.00039496102155 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | plasma membrane bounded cell projection part |
| HP:0012638 | 0.000618333366122 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of nervous system physiology |
| GO:0043473 | 0.00076806868397 | 0.5 | BBS4 BBS7 BBS5 BBS2 | pigmentation |
| HP:0000707 | 0.00104761430556 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Abnormality of the nervous system |
| GO:0015630 | 0.00140172168705 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | microtubule cytoskeleton |
| GO:0008134 | 0.0024030857736 | 0.75 | BBS4 BBS5 BBS2 BBS7 BBS1 TTC8 | transcription factor binding |
| GO:0120036 | 0.00243447233413 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | plasma membrane bounded cell projection organization |
| GO:0030030 | 0.00262503225591 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | cell projection organization |
| HP:0001156 | 0.00395521203096 | 0.5 | BBS4 LZTFL1 BBS5 BBS1 | Brachydactyly |
| HP:0000005 | 0.00474205424726 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Mode of inheritance |
| GO:0120025 | 0.00603881254865 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | plasma membrane bounded cell projection |
| GO:0042995 | 0.00641275397842 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | cell projection |
| GO:0044430 | 0.0075667656243 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | cytoskeletal part |
| HP:0000118 | 0.0083794460066 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | Phenotypic abnormality |
| HP:0000001 | 0.00847198455955 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | HP root |
| GO:0045444 | 0.00894888598316 | 0.5 | BBS9 BBS7 BBS2 BBS4 | fat cell differentiation |
| CORUM:0000000 | 0.00993810898821 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | CORUM root |
| GO:0045494 | 0.0131467756501 | 0.375 | BBS4 BBS2 BBS1 | photoreceptor cell maintenance |
| WP:000000 | 0.0134045376724 | 1.0 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 LZTFL1 | WIKIPATHWAYS |
| HP:0011927 | 0.021879554628 | 0.5 | BBS4 LZTFL1 BBS5 BBS1 | Short digit |
| GO:1905515 | 0.0227001216234 | 0.375 | BBS4 TTC8 BBS1 | non-motile cilium assembly |
| GO:0005856 | 0.0335519954693 | 0.875 | BBS9 BBS5 BBS4 BBS2 BBS7 BBS1 TTC8 | cytoskeleton |
| GO:0001947 | 0.0360121609904 | 0.375 | BBS4 BBS5 BBS7 | heart looping |
| GO:0050893 | 0.0378589948753 | 0.25 | BBS4 TTC8 | sensory processing |
| GO:0038108 | 0.0378589948753 | 0.25 | BBS4 BBS2 | negative regulation of appetite by leptin-mediated signaling pathway |
| HP:0000662 | 0.0391984812791 | 0.375 | BBS4 TTC8 BBS2 | Nyctalopia |
| GO:0051650 | 0.0412841915155 | 0.5 | BBS4 BBS7 BBS5 BBS2 | establishment of vesicle localization |
| GO:0061371 | 0.0425273681945 | 0.375 | BBS4 BBS5 BBS7 | determination of heart left/right asymmetry |
| GO:0007389 | 0.0491069431702 | 0.5 | BBS4 BBS5 TTC8 BBS7 | pattern specification process |
| GO:0003143 | 0.0497817121827 | 0.375 | BBS4 BBS5 BBS7 | embryonic heart tube morphogenesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BBS1 | BBS5 | 0.997 | 0.93 | bioplex (BBS1,BBS5) bioplex_WMM boldt (BBS1,BBS5) boldt_WMM |
| BBS9 | BBS5 | 0.996 | 0.928 | bioplex (BBS5) bioplex_WMM boldt (BBS5,BBS9) boldt_WMM |
| BBS4 | BBS5 | 0.995 | 0.924 | bioplex (BBS5) bioplex_WMM boldt (BBS4,BBS5) boldt_WMM |
| BBS9 | BBS1 | 0.992 | 0.912 | bioplex (BBS1) bioplex_WMM boldt (BBS1,BBS9) boldt_WMM |
| TTC8 | BBS5 | 0.986 | 0.9 | bioplex (BBS5) bioplex_WMM boldt (BBS5,TTC8) boldt_WMM |
| BBS4 | BBS1 | 0.979 | 0.895 | bioplex (BBS1) bioplex_WMM boldt (BBS1,BBS4) boldt_WMM |
| BBS2 | BBS7 | 0.976 | 0.891 | bioplex (BBS7) bioplex_WMM boldt (BBS2,BBS7) boldt_WMM |
| BBS1 | TTC8 | 0.973 | 0.886 | bioplex (BBS1) bioplex_WMM boldt (BBS1,TTC8) boldt_WMM |
| BBS2 | BBS5 | 0.948 | 0.857 | bioplex (BBS5) bioplex_WMM boldt (BBS2,BBS5) boldt_WMM |
| BBS9 | BBS7 | 0.858 | 0.795 | bioplex (BBS7) bioplex_WMM boldt (BBS9) boldt_WMM |
| BBS7 | BBS5 | 0.823 | 0.774 | bioplex (BBS5,BBS7) bioplex_WMM boldt (BBS5) boldt_WMM |
| BBS1 | BBS2 | 0.699 | 0.721 | bioplex (BBS1) bioplex_WMM boldt (BBS1,BBS2) boldt_WMM |
| BBS1 | BBS7 | 0.444 | 0.587 | bioplex (BBS1,BBS7) bioplex_WMM boldt (BBS1) boldt_WMM |
| BBS4 | BBS7 | 0.324 | 0.513 | bioplex (BBS7) bioplex_WMM boldt (BBS4) boldt_WMM |
| BBS4 | LZTFL1 | 0.181 | 0.436 | bioplex (LZTFL1) bioplex_WMM |
| BBS7 | TTC8 | 0.169 | 0.426 | bioplex (BBS7) bioplex_WMM boldt (TTC8) boldt_WMM |
| BBS9 | TTC8 | 0.146 | 0.409 | bioplex_WMM boldt (BBS9,TTC8) boldt_WMM |
| BBS9 | BBS2 | 0.112 | 0.381 | bioplex_WMM boldt (BBS2,BBS9) boldt_WMM |
| BBS4 | TTC8 | 0.088 | 0.353 | bioplex_WMM boldt (BBS4,TTC8) boldt_WMM |
| BBS9 | LZTFL1 | 0.045 | 0.286 | bioplex (LZTFL1) bioplex_WMM boldt (BBS9,LZTFL1) boldt_WMM |
| BBS9 | BBS4 | 0.039 | 0.265 | bioplex_WMM boldt (BBS4) boldt_WMM |
| BBS5 | LZTFL1 | 0.036 | 0.264 | bioplex (LZTFL1) bioplex_WMM boldt (LZTFL1) boldt_WMM |
| BBS2 | TTC8 | 0.025 | 0.213 | bioplex_WMM boldt (TTC8) boldt_WMM |
| BBS4 | BBS2 | 0.021 | 0.187 | bioplex_WMM boldt (BBS4) boldt_WMM |
| BBS7 | LZTFL1 | 0.013 | 0.148 | bioplex (LZTFL1) bioplex_WMM boldt (LZTFL1) boldt_WMM |
| BBS2 | LZTFL1 | 0.009 | 0.106 | bioplex (LZTFL1) bioplex_WMM boldt (LZTFL1) boldt_WMM |
| TTC8 | LZTFL1 | 0.0 | 0.009 | bioplex (LZTFL1) bioplex_WMM boldt boldt_WMM |
| BBS1 | LZTFL1 | 0.0 | 0.013 | bioplex (LZTFL1) bioplex_WMM boldt boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_02234 has an average edge precision of 0.536 which is ranked 2297 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BBS9 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| BBS1 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| BBS7 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 HuMAP2_05079 |
| TTC8 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| BBS4 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| BBS2 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| BBS5 | HuMAP2_00695 HuMAP2_02234 HuMAP2_04530 |
| LZTFL1 | HuMAP2_02234 HuMAP2_04530 HuMAP2_05368 |