hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02235
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DCAF1 | DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) | UniProt NCBI |
| DDA1 | DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1) | UniProt NCBI |
| DDB1 | DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) | UniProt NCBI |
| DCAF16 | DDB1- and CUL4-associated factor 16 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0080008 | 9.98266370523e-07 | 1.0 | DCAF1 DCAF16 DDA1 DDB1 | Cul4-RING E3 ubiquitin ligase complex |
| CORUM:6290 | 3.01612206104e-05 | 0.5 | DCAF1 DDB1 | Ubiquitin E3 ligase (DDB1, DYRK2, EDD, VPRBP) |
| GO:0031461 | 0.000468165581659 | 1.0 | DCAF1 DCAF16 DDA1 DDB1 | cullin-RING ubiquitin ligase complex |
| REAC:R-HSA-8951664 | 0.00240260362929 | 0.75 | DDB1 DDA1 DCAF16 | Neddylation |
| GO:0000151 | 0.0043315821947 | 1.0 | DCAF1 DCAF16 DDA1 DDB1 | ubiquitin ligase complex |
| WP:WP4541 | 0.00857683911078 | 0.5 | DCAF1 DDB1 | Hippo-Merlin Signaling Dysregulation |
| KEGG:05170 | 0.0387812861874 | 0.5 | DCAF1 DDB1 | Human immunodeficiency virus 1 infection |
| HPA:048020_21 | 0.0443196127196 | 0.75 | DCAF1 DDA1 DDB1 | soft tissue 2; chondrocytes[Approved,Low] |
| CORUM:790 | 0.0499140284799 | 0.25 | DDB1 | DDB complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DCAF1 | DDA1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt hein (DDA1) Malo fraction boldt_WMM |
| DDA1 | DDB1 | 0.741 | 0.74 | hein_WMM bioplex_WMM Guru boldt hein (DDB1) fraction boldt_WMM |
| DCAF1 | DDB1 | 0.239 | 0.47 | hein_WMM bioplex_WMM Guru boldt hein (DDB1) gupta_WMM fraction boldt_WMM |
| DCAF16 | DDB1 | 0.051 | 0.296 | hein_WMM bioplex_WMM boldt hein (DDB1) boldt_WMM |
| DCAF16 | DDA1 | 0.007 | 0.008 | hein_WMM bioplex_WMM WMM_only |
| DCAF16 | DCAF1 | 0.007 | 0.005 | hein_WMM bioplex_WMM boldt boldt_WMM |
Images
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Complex HuMAP2_02235 has an average edge precision of 0.411 which is ranked 3184 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DCAF1 | HuMAP2_01953 HuMAP2_02235 HuMAP2_06545 |
| DDA1 | HuMAP2_01953 HuMAP2_02235 HuMAP2_06545 |
| DDB1 | HuMAP2_02235 HuMAP2_04142 HuMAP2_04937 |
| DCAF16 | HuMAP2_01287 HuMAP2_02235 HuMAP2_04937 HuMAP2_06455 |