hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02238
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LIN7B | Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2) | UniProt NCBI |
| LIN7C | Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) | UniProt NCBI |
| LIN7A | Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1) | UniProt NCBI |
| CRB3 | Protein crumbs homolog 3 | UniProt NCBI |
| AMOTL2 | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | UniProt NCBI |
| MPDZ | Multiple PDZ domain protein (Multi-PDZ domain protein 1) | UniProt NCBI |
| MPP5 | MAGUK p55 subfamily member 5 | UniProt NCBI |
| MPP6 | MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1) | UniProt NCBI |
| MPP2 | MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2) | UniProt NCBI |
| RPH3A | Rabphilin-3A (Exophilin-1) | UniProt NCBI |
| PATJ | NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:848 | 5.66816007784e-07 | 0.3 | AMOTL2 MPP5 MPDZ | RICH1/AMOT polarity complex, Flag-Amot precipitated |
| CORUM:1089 | 3.01890677263e-05 | 0.2 | MPP6 LIN7A | VAM1-VELI1 complex |
| GO:0097016 | 4.35775472874e-05 | 0.3 | LIN7A LIN7B LIN7C | L27 domain binding |
| REAC:R-HSA-212676 | 6.0263228955e-05 | 0.3 | LIN7A LIN7B LIN7C | Dopamine Neurotransmitter Release Cycle |
| KEGG:04530 | 8.31453957977e-05 | 0.4 | AMOTL2 CRB3 MPP5 MPDZ | Tight junction |
| GO:0097025 | 0.000108905457596 | 0.3 | LIN7A LIN7B LIN7C | MPP7-DLG1-LIN7 complex |
| REAC:R-HSA-9609736 | 0.000379954732889 | 0.3 | LIN7A LIN7B LIN7C | Assembly and cell surface presentation of NMDA receptors |
| GO:1903361 | 0.000380900357231 | 0.3 | LIN7A LIN7B LIN7C | protein localization to basolateral plasma membrane |
| REAC:R-HSA-112310 | 0.000411472353333 | 0.3 | LIN7A LIN7B LIN7C | Neurotransmitter release cycle |
| GO:0035090 | 0.000609225680053 | 0.3 | LIN7A LIN7B LIN7C | maintenance of apical/basal cell polarity |
| GO:0045199 | 0.000609225680053 | 0.3 | LIN7A LIN7B LIN7C | maintenance of epithelial cell apical/basal polarity |
| REAC:R-HSA-6794361 | 0.00104952641894 | 0.3 | LIN7A LIN7B LIN7C | Neurexins and neuroligins |
| GO:0030011 | 0.00310592047764 | 0.3 | LIN7A LIN7B LIN7C | maintenance of cell polarity |
| REAC:R-HSA-6794362 | 0.00378486051784 | 0.3 | LIN7A LIN7B LIN7C | Protein-protein interactions at synapses |
| REAC:R-HSA-442755 | 0.00422239142849 | 0.3 | LIN7A LIN7B LIN7C | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-420029 | 0.00887131457927 | 0.2 | MPP5 CRB3 | Tight junction interactions |
| GO:0005911 | 0.0228941278645 | 0.5 | AMOTL2 LIN7A LIN7B MPP5 LIN7C | cell-cell junction |
| REAC:R-HSA-112314 | 0.0376731447737 | 0.3 | LIN7A LIN7B LIN7C | Neurotransmitter receptors and postsynaptic signal transmission |
| GO:0045197 | 0.0438273782088 | 0.3 | LIN7A LIN7B LIN7C | establishment or maintenance of epithelial cell apical/basal polarity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LIN7C | PATJ | 1.0 | 0.949 | hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C) |
| LIN7C | MPP2 | 1.0 | 0.949 | bioplex (LIN7C,MPP2) bioplex_WMM |
| LIN7C | MPDZ | 1.0 | 0.949 | hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C) |
| LIN7C | MPP5 | 1.0 | 0.949 | hein_WMM bioplex (LIN7C,MPP5) bioplex_WMM hein (LIN7C) gupta_WMM |
| LIN7C | MPP6 | 1.0 | 0.949 | hein_WMM bioplex (LIN7C) bioplex_WMM hein (LIN7C,MPP6) |
| LIN7B | LIN7C | 1.0 | 0.949 | bioplex (LIN7C) bioplex_WMM |
| LIN7B | MPP2 | 0.963 | 0.871 | bioplex (MPP2) bioplex_WMM |
| MPDZ | MPP5 | 0.916 | 0.84 | hein_WMM bioplex (MPP5) bioplex_WMM fraction |
| PATJ | MPP5 | 0.823 | 0.774 | hein_WMM bioplex (MPP5) bioplex_WMM |
| CRB3 | MPP5 | 0.782 | 0.756 | bioplex (MPP5) bioplex_WMM |
| LIN7B | MPP5 | 0.592 | 0.665 | bioplex (MPP5) bioplex_WMM |
| AMOTL2 | MPP5 | 0.587 | 0.662 | hein_WMM bioplex (MPP5) bioplex_WMM |
| LIN7A | MPP2 | 0.456 | 0.596 | bioplex (MPP2) bioplex_WMM |
| RPH3A | MPP5 | 0.239 | 0.47 | bioplex (MPP5) bioplex_WMM |
| MPP6 | MPP2 | 0.024 | 0.213 | bioplex (MPP2) bioplex_WMM |
| MPP5 | LIN7A | 0.021 | 0.189 | bioplex (MPP5) bioplex_WMM |
| MPP6 | LIN7A | 0.012 | 0.149 | bioplex_WMM WMM_only |
| LIN7C | LIN7A | 0.011 | 0.148 | bioplex_WMM WMM_only |
| LIN7B | MPDZ | 0.011 | 0.141 | bioplex_WMM WMM_only |
| MPDZ | PATJ | 0.011 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| LIN7B | PATJ | 0.01 | 0.139 | bioplex_WMM WMM_only |
| AMOTL2 | LIN7C | 0.01 | 0.122 | hein_WMM bioplex_WMM hein (LIN7C) |
| LIN7B | MPP6 | 0.009 | 0.11 | bioplex_WMM WMM_only |
| LIN7B | LIN7A | 0.009 | 0.109 | bioplex_WMM WMM_only |
| MPP5 | MPP6 | 0.009 | 0.095 | hein_WMM bioplex_WMM WMM_only |
| AMOTL2 | MPDZ | 0.009 | 0.096 | hein_WMM bioplex_WMM WMM_only |
| MPDZ | MPP2 | 0.008 | 0.094 | bioplex_WMM WMM_only |
| CRB3 | MPDZ | 0.008 | 0.093 | bioplex_WMM WMM_only |
| CRB3 | AMOTL2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| PATJ | MPP2 | 0.008 | 0.089 | bioplex_WMM WMM_only |
| CRB3 | PATJ | 0.008 | 0.087 | bioplex_WMM WMM_only |
| LIN7B | CRB3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| MPP5 | MPP2 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| RPH3A | CRB3 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| AMOTL2 | PATJ | 0.008 | 0.085 | hein_WMM bioplex_WMM WMM_only |
| MPDZ | MPP6 | 0.008 | 0.079 | hein_WMM bioplex_WMM WMM_only |
| CRB3 | LIN7A | 0.008 | 0.068 | bioplex_WMM WMM_only |
| LIN7B | AMOTL2 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| CRB3 | LIN7C | 0.008 | 0.07 | bioplex_WMM WMM_only |
| RPH3A | MPDZ | 0.008 | 0.059 | bioplex_WMM WMM_only |
| RPH3A | AMOTL2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| PATJ | MPP6 | 0.008 | 0.044 | hein_WMM bioplex_WMM WMM_only |
| MPDZ | LIN7A | 0.008 | 0.044 | bioplex_WMM WMM_only |
| AMOTL2 | LIN7A | 0.008 | 0.046 | bioplex_WMM WMM_only |
| RPH3A | PATJ | 0.008 | 0.043 | bioplex_WMM WMM_only |
| RPH3A | LIN7B | 0.008 | 0.04 | bioplex_WMM WMM_only |
| PATJ | LIN7A | 0.008 | 0.019 | bioplex_WMM WMM_only |
| RPH3A | LIN7A | 0.008 | 0.015 | bioplex_WMM WMM_only |
| RPH3A | LIN7C | 0.008 | 0.01 | bioplex_WMM WMM_only |
| AMOTL2 | MPP6 | 0.008 | 0.012 | hein_WMM WMM_only |
Images
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Complex HuMAP2_02238 has an average edge precision of 0.289 which is ranked 4763 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LIN7B | HuMAP2_01171 HuMAP2_01555 HuMAP2_02238 HuMAP2_03001 |
| LIN7C | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 |
| LIN7A | HuMAP2_01555 HuMAP2_02238 HuMAP2_03001 |
| CRB3 | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04805 |
| AMOTL2 | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04011 HuMAP2_04805 |
| MPDZ | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 |
| MPP5 | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04805 |
| MPP6 | HuMAP2_01555 HuMAP2_02238 HuMAP2_03001 |
| MPP2 | HuMAP2_01555 HuMAP2_02238 HuMAP2_03001 |
| RPH3A | HuMAP2_01095 HuMAP2_01645 HuMAP2_02238 |
| PATJ | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_03401 |