hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02248
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLC30A9 | Zinc transporter 9 (ZnT-9) (Human embryonic lung protein) (HuEL) (Solute carrier family 30 member 9) | UniProt NCBI |
| COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) | UniProt NCBI |
| SRPRA | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | UniProt NCBI |
| COX6C | Cytochrome c oxidase subunit 6C (Cytochrome c oxidase polypeptide VIc) | UniProt NCBI |
| COX5A | Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6442 | 4.91389011565e-07 | 0.6 | COX6C COX4I1 COX5A | Cytochrome c oxidase, mitochondrial |
| KEGG:04260 | 6.03589367445e-05 | 0.6 | COX6C COX4I1 COX5A | Cardiac muscle contraction |
| WP:WP111 | 8.65079697906e-05 | 0.6 | COX6C COX4I1 COX5A | Electron Transport Chain (OXPHOS system in mitochondria) |
| REAC:R-HSA-5628897 | 0.000221673564929 | 0.6 | COX6C COX4I1 COX5A | TP53 Regulates Metabolic Genes |
| KEGG:00190 | 0.000228199807064 | 0.6 | COX6C COX4I1 COX5A | Oxidative phosphorylation |
| KEGG:05012 | 0.000278060757653 | 0.6 | COX6C COX4I1 COX5A | Parkinson disease |
| WP:WP4396 | 0.000278228795868 | 0.6 | COX6C COX4I1 COX5A | Nonalcoholic fatty liver disease |
| KEGG:04932 | 0.000327209764734 | 0.6 | COX6C COX4I1 COX5A | Non-alcoholic fatty liver disease (NAFLD) |
| REAC:R-HSA-611105 | 0.000361148609859 | 0.6 | COX6C COX4I1 COX5A | Respiratory electron transport |
| KEGG:05010 | 0.000508464109821 | 0.6 | COX6C COX4I1 COX5A | Alzheimer disease |
| REAC:R-HSA-163200 | 0.000681366686347 | 0.6 | COX6C COX4I1 COX5A | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| GO:0006123 | 0.000739960245213 | 0.6 | COX6C COX4I1 COX5A | mitochondrial electron transport, cytochrome c to oxygen |
| GO:0019646 | 0.000739960245213 | 0.6 | COX6C COX4I1 COX5A | aerobic electron transport chain |
| KEGG:05016 | 0.000759162382225 | 0.6 | COX6C COX4I1 COX5A | Huntington disease |
| KEGG:04714 | 0.00127045127527 | 0.6 | COX6C COX4I1 COX5A | Thermogenesis |
| REAC:R-HSA-1428517 | 0.00196642775139 | 0.6 | COX6C COX4I1 COX5A | The citric acid (TCA) cycle and respiratory electron transport |
| REAC:R-HSA-3700989 | 0.0182828935298 | 0.6 | COX6C COX4I1 COX5A | Transcriptional Regulation by TP53 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COX5A | SLC30A9 | 0.05 | 0.296 | bioplex (COX5A) bioplex_WMM boldt youn_WMM boldt_WMM |
| COX4I1 | COX5A | 0.048 | 0.294 | hein_WMM bioplex (COX4I1,COX5A) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SRPRA | COX5A | 0.041 | 0.269 | bioplex (SRPRA) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| COX5A | COX6C | 0.022 | 0.206 | bioplex (COX5A) bioplex_WMM boldt boldt_WMM |
| COX4I1 | SLC30A9 | 0.006 | 0.009 | bioplex_WMM boldt youn_WMM boldt_WMM |
| COX4I1 | SRPRA | 0.006 | 0.01 | bioplex (SRPRA) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SRPRA | SLC30A9 | 0.005 | 0.008 | bioplex_WMM boldt youn_WMM boldt_WMM |
| COX4I1 | COX6C | 0.005 | 0.008 | bioplex_WMM boldt boldt_WMM |
| SRPRA | COX6C | 0.004 | 0.013 | bioplex_WMM WMM_only |
| COX6C | SLC30A9 | 0.004 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02248 has an average edge precision of 0.112 which is ranked 6901 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SLC30A9 | HuMAP2_02248 HuMAP2_06129 |
| COX4I1 | HuMAP2_00163 HuMAP2_02248 HuMAP2_06129 |
| SRPRA | HuMAP2_01699 HuMAP2_02248 HuMAP2_02446 HuMAP2_05917 HuMAP2_06129 |
| COX6C | HuMAP2_02248 |
| COX5A | HuMAP2_01699 HuMAP2_02248 HuMAP2_06129 |