hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02250

Confidence: Medium High

Genename	Protein Name	Links
CHM	Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein)	UniProt NCBI
RAB5A	Ras-related protein Rab-5A	UniProt NCBI
RAB5C	Ras-related protein Rab-5C (L1880) (RAB5L)	UniProt NCBI
RAP1B	Ras-related protein Rap-1b (GTP-binding protein smg p21B)	UniProt NCBI
RAB7A	Ras-related protein Rab-7a	UniProt NCBI
RAB2A	Ras-related protein Rab-2A	UniProt NCBI
RAB5B	Ras-related protein Rab-5B	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8873719	4.7357784261e-12	0.857142857143	RAB5C RAB7A CHM RAB5B RAB5A RAB2A	RAB geranylgeranylation
GO:0019003	1.56495974842e-09	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	GDP binding
REAC:R-HSA-8876198	1.87038231933e-08	0.714285714286	RAB7A RAB5A CHM RAB5C RAB5B	RAB GEFs exchange GTP for GDP on RABs
REAC:R-HSA-9007101	9.11375597162e-08	0.714285714286	RAB7A RAB5A CHM RAB5C RAB5B	Rab regulation of trafficking
REAC:R-HSA-8854214	3.50207327458e-07	0.571428571429	RAB7A RAB5A RAB5B RAB5C	TBC/RABGAPs
GO:0032549	1.13529365231e-06	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	ribonucleoside binding
GO:0032550	1.13529365231e-06	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	purine ribonucleoside binding
GO:0001883	1.17327993584e-06	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	purine nucleoside binding
GO:0001882	1.29364697618e-06	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	nucleoside binding
GO:0032561	1.61498193868e-06	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	guanyl ribonucleotide binding
GO:0019001	1.66588439806e-06	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	guanyl nucleotide binding
KEGG:05146	1.78865964646e-06	0.571428571429	RAB7A RAB5A RAB5B RAB5C	Amoebiasis
GO:0032482	2.22330443069e-06	0.714285714286	RAB7A RAB5A RAB2A RAB5B RAB5C	Rab protein signal transduction
WP:WP4301	2.75100965618e-06	0.428571428571	RAB5A RAB5B RAB5C	Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells
GO:0003924	6.59666450892e-06	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	GTPase activity
KEGG:04145	1.15953300137e-05	0.571428571429	RAB7A RAB5A RAB5B RAB5C	Phagosome
KEGG:05152	1.77099885498e-05	0.571428571429	RAB7A RAB5A RAB5B RAB5C	Tuberculosis
GO:0007265	2.01711040488e-05	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	Ras protein signal transduction
WP:WP4223	2.05029835479e-05	0.571428571429	RAB5A RAB5B RAP1B RAB5C	Ras Signaling
KEGG:04962	3.26746785114e-05	0.428571428571	RAB5A RAB5B RAB5C	Vasopressin-regulated water reabsorption
KEGG:04014	4.01773404786e-05	0.571428571429	RAB5A RAB5B RAP1B RAB5C	Ras signaling pathway
KEGG:04144	9.9712356068e-05	0.571428571429	RAB7A RAB5A RAB5B RAB5C	Endocytosis
GO:0007264	0.000120054472817	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	small GTPase mediated signal transduction
REAC:R-HSA-199991	0.000292205838536	0.714285714286	RAB7A RAB5A CHM RAB5C RAB5B	Membrane Trafficking
REAC:R-HSA-5653656	0.000380974038787	0.714285714286	RAB7A RAB5A CHM RAB5C RAB5B	Vesicle-mediated transport
REAC:R-HSA-597592	0.00039194203242	0.857142857143	RAB5C RAB7A CHM RAB5B RAB5A RAB2A	Post-translational protein modification
GO:0032555	0.000434415170379	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	purine ribonucleotide binding
GO:0032553	0.000490048093969	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	ribonucleotide binding
GO:0017076	0.000501856146335	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	purine nucleotide binding
GO:0017111	0.00110442254565	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	nucleoside-triphosphatase activity
GO:0016462	0.00165115666388	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	pyrophosphatase activity
GO:0016817	0.0016835168135	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	hydrolase activity, acting on acid anhydrides
GO:0016818	0.0016835168135	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0000166	0.00190697135592	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	nucleotide binding
GO:1901265	0.0019251340575	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	nucleoside phosphate binding
GO:0097367	0.00303616827731	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	carbohydrate derivative binding
REAC:R-HSA-392499	0.00334345902737	0.857142857143	RAB5C RAB7A CHM RAB5B RAB5A RAB2A	Metabolism of proteins
REAC:R-HSA-8856828	0.00362218339674	0.428571428571	RAB5A RAB5B RAB5C	Clathrin-mediated endocytosis
REAC:R-HSA-6798695	0.00377687927301	0.571428571429	RAB7A RAB5C RAB5B RAP1B	Neutrophil degranulation
GO:0016192	0.00644216001439	1.0	RAB5C RAB5A RAB7A CHM RAB2A RAP1B RAB5B	vesicle-mediated transport
GO:0036094	0.0106938347644	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	small molecule binding
GO:0051649	0.015479871164	1.0	RAB5C RAB5A RAB7A CHM RAB2A RAP1B RAB5B	establishment of localization in cell
GO:0006886	0.0180209467821	0.857142857143	RAB5C RAB7A CHM RAB5B RAB5A RAB2A	intracellular protein transport
HPA:050010_22	0.0257859314735	0.714285714286	RAB5A RAB2A CHM RAB5C RAB5B	spleen; cells in red pulp[Approved,Medium]
HPA:027020_22	0.0259614800347	0.714285714286	RAB5A RAB2A CHM RAB5C RAB5B	lung; pneumocytes[Approved,Medium]
GO:0005525	0.0285804850445	0.571428571429	RAB7A RAB5A RAB2A RAP1B	GTP binding
GO:0030659	0.0383178003422	0.714285714286	RAB7A RAB5A RAB5B RAP1B RAB5C	cytoplasmic vesicle membrane
GO:0043168	0.0409932600941	0.857142857143	RAB5C RAP1B RAB7A RAB5B RAB5A RAB2A	anion binding
MIRNA:hsa-miR-4747-3p	0.0430700646909	0.285714285714	RAB5B RAB2A	hsa-miR-4747-3p
GO:0012506	0.0440427018254	0.714285714286	RAB7A RAB5A RAB5B RAP1B RAB5C	vesicle membrane
CORUM:2572	0.0499886427319	0.142857142857	RAB5A	RAB5-EEA1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
RAB5C	RAB5A	0.858	0.796	hein_WMM bioplex (RAB5A,RAB5C) bioplex_WMM youn_WMM hein (RAB5A) gupta_WMM boldt_WMM treiber_WMM
RAB7A	RAB5C	0.606	0.672	hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RAB7A	RAB5A	0.27	0.483	bioplex_WMM Guru gupta_WMM fraction boldt_WMM treiber_WMM
CHM	RAB5C	0.189	0.441	hein_WMM bioplex (RAB5C) bioplex_WMM youn_WMM hein (RAB5C)
RAB7A	RAB5B	0.17	0.426	hein_WMM bioplex_WMM Guru gupta_WMM fraction treiber_WMM
RAB7A	RAB2A	0.135	0.407	hein_WMM bioplex_WMM Guru boldt hein (RAB2A) gupta_WMM fraction boldt_WMM treiber_WMM
RAP1B	RAB7A	0.11	0.379	hein_WMM bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
RAB7A	CHM	0.051	0.302	hein_WMM bioplex_WMM hein (RAB7A)
CHM	RAB5A	0.045	0.279	bioplex (RAB5A) bioplex_WMM youn_WMM
RAB5C	RAB5B	0.032	0.246	hein_WMM bioplex_WMM youn_WMM hein (RAB5B,RAB5C) gupta_WMM treiber_WMM
RAB5A	RAB5B	0.009	0.109	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RAP1B	RAB5B	0.009	0.096	bioplex_WMM Guru gupta_WMM fraction
CHM	RAB5B	0.008	0.011	hein_WMM youn_WMM WMM_only
RAP1B	RAB2A	0.006	0.009	bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
RAB2A	RAB5B	0.0	0.01	bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RAB2A	RAB5A	0.0	0.006	bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RAP1B	RAB5C	0.0	0.003	hein_WMM bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
RAB2A	RAB5C	0.0	0.0	bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
RAP1B	RAB5A	0.0	0.001	bioplex_WMM Guru gupta_WMM fraction boldt_WMM

Images

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Complex HuMAP2_02250 has an average edge precision of 0.246 which is ranked 5435 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CHM	HuMAP2_01067 HuMAP2_02250 HuMAP2_03796 HuMAP2_07002
RAB5A	HuMAP2_01779 HuMAP2_02250 HuMAP2_05110 HuMAP2_05570
RAB5C	HuMAP2_01779 HuMAP2_02250 HuMAP2_04626 HuMAP2_05110 HuMAP2_05570
RAP1B	HuMAP2_00248 HuMAP2_02250 HuMAP2_04766 HuMAP2_05570 HuMAP2_05778 HuMAP2_05948 HuMAP2_06607
RAB7A	HuMAP2_00248 HuMAP2_02250 HuMAP2_05110 HuMAP2_05570 HuMAP2_05778 HuMAP2_05948
RAB2A	HuMAP2_00248 HuMAP2_00952 HuMAP2_02250 HuMAP2_02330 HuMAP2_04581 HuMAP2_05778 HuMAP2_05948 HuMAP2_07007
RAB5B	HuMAP2_02250 HuMAP2_04626 HuMAP2_05570 HuMAP2_05778

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02250