hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02252
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MESD | LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development LRP chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein) (Renal carcinoma antigen NY-REN-61) | UniProt NCBI |
| SUMF1 | Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1) | UniProt NCBI |
| ARSA | Arylsulfatase A (ASA) (EC 3.1.6.8) (Cerebroside-sulfatase) [Cleaved into: Arylsulfatase A component B; Arylsulfatase A component C] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1663150 | 0.000301184970683 | 0.666666666667 | SUMF1 ARSA | The activation of arylsulfatases |
| HP:0002922 | 0.00185475275658 | 0.666666666667 | SUMF1 ARSA | Increased CSF protein |
| HP:0025456 | 0.00204013662007 | 0.666666666667 | SUMF1 ARSA | Abnormal CSF protein level |
| KEGG:04142 | 0.00307537091529 | 0.666666666667 | SUMF1 ARSA | Lysosome |
| REAC:R-HSA-163841 | 0.00397787610966 | 0.666666666667 | SUMF1 ARSA | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| REAC:R-HSA-1660662 | 0.00521352578002 | 0.666666666667 | SUMF1 ARSA | Glycosphingolipid metabolism |
| HP:0011096 | 0.00620427636329 | 0.666666666667 | SUMF1 ARSA | Peripheral demyelination |
| HP:0002344 | 0.0068832170429 | 0.666666666667 | SUMF1 ARSA | Progressive neurologic deterioration |
| HP:0002518 | 0.0161338784795 | 0.666666666667 | SUMF1 ARSA | Abnormality of the periventricular white matter |
| REAC:R-HSA-428157 | 0.0180259784934 | 0.666666666667 | SUMF1 ARSA | Sphingolipid metabolism |
| HP:0003130 | 0.0307019877242 | 0.666666666667 | SUMF1 ARSA | Abnormal peripheral myelination |
| HP:0003134 | 0.041834410056 | 0.666666666667 | SUMF1 ARSA | Abnormality of peripheral nerve conduction |
| HP:0045010 | 0.044442515366 | 0.666666666667 | SUMF1 ARSA | Abnormality of peripheral nerves |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ARSA | SUMF1 | 0.605 | 0.672 | bioplex (ARSA) bioplex_WMM |
| ARSA | MESD | 0.063 | 0.346 | bioplex (ARSA) bioplex_WMM |
| SUMF1 | MESD | 0.006 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02252 has an average edge precision of 0.34 which is ranked 4118 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MESD | HuMAP2_01300 HuMAP2_01923 HuMAP2_02252 HuMAP2_07005 |
| SUMF1 | HuMAP2_00451 HuMAP2_02252 HuMAP2_03210 |
| ARSA | HuMAP2_00018 HuMAP2_02252 HuMAP2_03210 HuMAP2_07005 |