hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02257
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NPAS1 | Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5) | UniProt NCBI |
| ARNT2 | Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2) (Class E basic helix-loop-helix protein 1) (bHLHe1) | UniProt NCBI |
| FOXR2 | Forkhead box protein R2 (Forkhead box protein N6) | UniProt NCBI |
| ARNT | Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta) | UniProt NCBI |
| MYC | Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8937144 | 0.000202356855584 | 0.4 | ARNT ARNT2 | Aryl hydrocarbon receptor signalling |
| WP:WP4241 | 0.00144719807027 | 0.4 | ARNT ARNT2 | Type 2 papillary renal cell carcinoma |
| REAC:R-HSA-211976 | 0.00282729215335 | 0.4 | ARNT ARNT2 | Endogenous sterols |
| WP:WP2586 | 0.00285983596887 | 0.4 | ARNT MYC | Aryl Hydrocarbon Receptor |
| REAC:R-HSA-211981 | 0.0031096034254 | 0.4 | ARNT ARNT2 | Xenobiotics |
| KEGG:05211 | 0.00831682765542 | 0.4 | ARNT ARNT2 | Renal cell carcinoma |
| KEGG:05200 | 0.0137388951306 | 0.6 | ARNT MYC ARNT2 | Pathways in cancer |
| GO:0000790 | 0.0171953090779 | 1.0 | ARNT ARNT2 FOXR2 MYC NPAS1 | nuclear chromatin |
| REAC:R-HSA-211897 | 0.0184727645209 | 0.4 | ARNT ARNT2 | Cytochrome P450 - arranged by substrate type |
| GO:0000981 | 0.0187192194024 | 1.0 | ARNT ARNT2 FOXR2 MYC NPAS1 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000785 | 0.0394223237212 | 1.0 | ARNT ARNT2 FOXR2 MYC NPAS1 | chromatin |
| WP:WP3594 | 0.0426212197502 | 0.4 | ARNT ARNT2 | Circadian rhythm related genes |
| GO:0003700 | 0.0459792824187 | 1.0 | ARNT ARNT2 FOXR2 MYC NPAS1 | DNA-binding transcription factor activity |
| GO:0044454 | 0.046479053704 | 1.0 | ARNT ARNT2 FOXR2 MYC NPAS1 | nuclear chromosome part |
| REAC:R-HSA-211945 | 0.0476518941102 | 0.4 | ARNT ARNT2 | Phase I - Functionalization of compounds |
| CORUM:2152 | 0.0499494897235 | 0.2 | ARNT | ARNT-HLF complex |
| CORUM:2655 | 0.0499494897235 | 0.2 | MYC | MYC-MAX complex |
| CORUM:3052 | 0.0499494897235 | 0.2 | MYC | MYC-MAX complex |
| CORUM:4043 | 0.0499494897235 | 0.2 | ARNT | NEMO-HIF2(alpha)-ARNT complex |
| CORUM:5382 | 0.0499494897235 | 0.2 | ARNT | ARNT-HIF1A complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FOXR2 | ARNT | 0.932 | 0.846 | bioplex (FOXR2) bioplex_WMM |
| MYC | FOXR2 | 0.928 | 0.844 | bioplex (FOXR2) bioplex_WMM |
| ARNT | NPAS1 | 0.712 | 0.728 | bioplex (NPAS1) bioplex_WMM |
| ARNT2 | NPAS1 | 0.201 | 0.451 | bioplex (NPAS1) bioplex_WMM |
| MYC | ARNT | 0.008 | 0.059 | bioplex_WMM WMM_only |
| ARNT2 | ARNT | 0.008 | 0.042 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02257 has an average edge precision of 0.495 which is ranked 2529 out of all 6965 complexes.
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