hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02259
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDH3 | Cadherin-3 (Placental cadherin) (P-cadherin) | UniProt NCBI |
| CTNNA3 | Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein) | UniProt NCBI |
| CDH12 | Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2) | UniProt NCBI |
| CDH4 | Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418990 | 3.94532681474e-06 | 0.75 | CDH12 CDH3 CDH4 | Adherens junctions interactions |
| REAC:R-HSA-421270 | 1.78485863117e-05 | 0.75 | CDH12 CDH3 CDH4 | Cell-cell junction organization |
| WP:WP4540 | 2.38151267007e-05 | 0.75 | CDH12 CDH3 CDH4 | Pathways Regulating Hippo Signaling |
| WP:WP4541 | 3.85485625527e-05 | 0.75 | CDH12 CDH3 CDH4 | Hippo-Merlin Signaling Dysregulation |
| GO:0005913 | 5.95648368816e-05 | 1.0 | CDH4 CTNNA3 CDH3 CDH12 | cell-cell adherens junction |
| REAC:R-HSA-446728 | 7.69213089466e-05 | 0.75 | CDH12 CDH3 CDH4 | Cell junction organization |
| REAC:R-HSA-1500931 | 0.000237627678426 | 0.75 | CDH12 CDH3 CDH4 | Cell-Cell communication |
| GO:0016342 | 0.000558907067709 | 0.75 | CDH12 CDH3 CDH4 | catenin complex |
| GO:0016339 | 0.00197902980402 | 0.75 | CDH12 CDH3 CDH4 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0044331 | 0.00237379826551 | 0.75 | CDH12 CDH3 CDH4 | cell-cell adhesion mediated by cadherin |
| GO:0005911 | 0.00544194080262 | 1.0 | CDH4 CTNNA3 CDH3 CDH12 | cell-cell junction |
| KEGG:04514 | 0.0100290139666 | 0.5 | CDH4 CDH3 | Cell adhesion molecules (CAMs) |
| GO:0045296 | 0.0101996106268 | 1.0 | CDH4 CTNNA3 CDH3 CDH12 | cadherin binding |
| GO:0007156 | 0.0106004966657 | 0.75 | CDH12 CDH3 CDH4 | homophilic cell adhesion via plasma membrane adhesion molecules |
| GO:0050839 | 0.0382716890733 | 1.0 | CDH4 CTNNA3 CDH3 CDH12 | cell adhesion molecule binding |
| GO:0005912 | 0.0433740392707 | 1.0 | CDH4 CTNNA3 CDH3 CDH12 | adherens junction |
| GO:0007043 | 0.0439367749778 | 0.75 | CDH12 CDH3 CDH4 | cell-cell junction assembly |
| GO:0070161 | 0.0477280075644 | 1.0 | CDH4 CTNNA3 CDH3 CDH12 | anchoring junction |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CTNNA3 | CDH4 | 0.998 | 0.939 | bioplex (CTNNA3) bioplex_WMM |
| CTNNA3 | CDH3 | 0.882 | 0.817 | bioplex (CTNNA3) bioplex_WMM |
| CTNNA3 | CDH12 | 0.722 | 0.732 | bioplex (CTNNA3) bioplex_WMM |
| CDH12 | CDH4 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| CDH12 | CDH3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CDH4 | CDH3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02259 has an average edge precision of 0.461 which is ranked 2798 out of all 6965 complexes.
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