hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02274
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AMER1 | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) | UniProt NCBI |
| CDH1 | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | UniProt NCBI |
| APC | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | UniProt NCBI |
| CTNNA3 | Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05213 | 7.85221975235e-06 | 0.75 | CTNNA3 CDH1 APC | Endometrial cancer |
| WP:WP4155 | 8.50820332609e-06 | 0.75 | CTNNA3 CDH1 APC | Endometrial cancer |
| GO:0008013 | 1.55003541896e-05 | 1.0 | AMER1 CDH1 APC CTNNA3 | beta-catenin binding |
| KEGG:05226 | 9.7891531883e-05 | 0.75 | CTNNA3 CDH1 APC | Gastric cancer |
| KEGG:04390 | 0.000124834325776 | 0.75 | CTNNA3 CDH1 APC | Hippo signaling pathway |
| HP:0200040 | 0.000817788537784 | 0.5 | APC CDH1 | Epidermoid cyst |
| REAC:R-HSA-4839744 | 0.000914071346391 | 0.5 | AMER1 APC | truncated APC mutants destabilize the destruction complex |
| REAC:R-HSA-5467348 | 0.000914071346391 | 0.5 | AMER1 APC | Truncations of AMER1 destabilize the destruction complex |
| REAC:R-HSA-4839748 | 0.000914071346391 | 0.5 | AMER1 APC | AMER1 mutants destabilize the destruction complex |
| REAC:R-HSA-5467337 | 0.000914071346391 | 0.5 | AMER1 APC | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-5467340 | 0.000914071346391 | 0.5 | AMER1 APC | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-4839735 | 0.000914071346391 | 0.5 | AMER1 APC | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| REAC:R-HSA-5358751 | 0.00105460323216 | 0.5 | AMER1 APC | S45 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358749 | 0.00105460323216 | 0.5 | AMER1 APC | S37 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358747 | 0.00105460323216 | 0.5 | AMER1 APC | S33 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5339716 | 0.00105460323216 | 0.5 | AMER1 APC | Misspliced GSK3beta mutants stabilize beta-catenin |
| REAC:R-HSA-4839743 | 0.00105460323216 | 0.5 | AMER1 APC | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| REAC:R-HSA-5358752 | 0.00105460323216 | 0.5 | AMER1 APC | T41 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-196299 | 0.00136571756437 | 0.5 | AMER1 APC | Beta-catenin phosphorylation cascade |
| HP:0025245 | 0.00206626211915 | 0.5 | APC CDH1 | Cutaneous cyst |
| HP:0006292 | 0.00261158200619 | 0.75 | AMER1 CDH1 APC | Abnormality of dental eruption |
| REAC:R-HSA-4641262 | 0.00436320194063 | 0.5 | AMER1 APC | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| REAC:R-HSA-4791275 | 0.00436320194063 | 0.5 | AMER1 APC | Signaling by WNT in cancer |
| KEGG:05200 | 0.00437599198048 | 0.75 | CTNNA3 CDH1 APC | Pathways in cancer |
| KEGG:04520 | 0.00467243468204 | 0.5 | CTNNA3 CDH1 | Adherens junction |
| KEGG:05100 | 0.00523220354961 | 0.5 | CTNNA3 CDH1 | Bacterial invasion of epithelial cells |
| HP:0012126 | 0.00524136889643 | 0.5 | APC CDH1 | Stomach cancer |
| REAC:R-HSA-111465 | 0.00667602194349 | 0.5 | APC CDH1 | Apoptotic cleavage of cellular proteins |
| HP:0012125 | 0.00796059020261 | 0.5 | APC CDH1 | Prostate cancer |
| HP:0100787 | 0.00796059020261 | 0.5 | APC CDH1 | Prostate neoplasm |
| HP:0000769 | 0.0110123794702 | 0.75 | AMER1 CDH1 APC | Abnormality of the breast |
| HP:0031093 | 0.0110123794702 | 0.75 | AMER1 CDH1 APC | Abnormal breast morphology |
| HP:0008775 | 0.0119684664945 | 0.5 | APC CDH1 | Abnormal prostate morphology |
| REAC:R-HSA-75153 | 0.012764635731 | 0.5 | APC CDH1 | Apoptotic execution phase |
| HP:0010784 | 0.0176695962482 | 0.5 | APC CDH1 | Uterine neoplasm |
| HP:0000022 | 0.023433582519 | 0.5 | APC CDH1 | Abnormality of male internal genitalia |
| GO:1904885 | 0.0270421395626 | 0.5 | AMER1 APC | beta-catenin destruction complex assembly |
| HP:0000656 | 0.0288545127028 | 0.5 | APC CDH1 | Ectropion |
| REAC:R-HSA-195253 | 0.0331557329305 | 0.5 | AMER1 APC | Degradation of beta-catenin by the destruction complex |
| HP:0003002 | 0.0335949626331 | 0.5 | APC CDH1 | Breast carcinoma |
| HP:0006753 | 0.0360996225593 | 0.5 | APC CDH1 | Neoplasm of the stomach |
| HP:0002577 | 0.0374270741742 | 0.75 | AMER1 CDH1 APC | Abnormality of the stomach |
| GO:0005913 | 0.0410761885593 | 0.75 | CTNNA3 CDH1 APC | cell-cell adherens junction |
| CORUM:5319 | 0.0499140284799 | 0.25 | CDH1 | CDH1-CKS1B complex |
| CORUM:5281 | 0.0499140284799 | 0.25 | CDH1 | Cell-cell junction complex (CDH1-CTNNB1) |
| CORUM:1909 | 0.0499140284799 | 0.25 | APC | APC-DLG4 complex |
| CORUM:1844 | 0.0499140284799 | 0.25 | APC | APC-IQGAP1 complex |
| CORUM:933 | 0.0499140284799 | 0.25 | APC | SCRIB-APC complex |
| CORUM:5320 | 0.0499140284799 | 0.25 | CDH1 | CDH1-SKP2 complex |
| REAC:R-HSA-5467333 | 0.0499190562503 | 0.25 | APC | APC truncation mutants are not K63 polyubiquitinated |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CTNNA3 | CDH1 | 0.435 | 0.579 | bioplex (CTNNA3) bioplex_WMM |
| CTNNA3 | APC | 0.145 | 0.408 | bioplex (CTNNA3) bioplex_WMM |
| AMER1 | APC | 0.144 | 0.406 | hein_WMM bioplex_WMM youn_WMM hein (APC) |
| CDH1 | APC | 0.007 | 0.006 | bioplex_WMM WMM_only |
| CDH1 | AMER1 | 0.007 | 0.016 | bioplex_WMM WMM_only |
| CTNNA3 | AMER1 | 0.004 | 0.011 | bioplex (CTNNA3) bioplex_WMM |
Images
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Complex HuMAP2_02274 has an average edge precision of 0.238 which is ranked 5576 out of all 6965 complexes.
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