hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02281
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DNAJC2 | DnaJ homolog subfamily C member 2 (M-phase phosphoprotein 11) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed] | UniProt NCBI |
| EIF2A | Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed] | UniProt NCBI |
| HSPA14 | Heat shock 70 kDa protein 14 (HSP70-like protein 1) (Heat shock protein HSP60) | UniProt NCBI |
| DDX3X | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (Helicase-like protein 2) (HLP2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051083 | 0.00270494046827 | 0.5 | DNAJC2 HSPA14 | 'de novo' cotranslational protein folding |
| REAC:R-HSA-3371453 | 0.0207977326435 | 0.5 | DNAJC2 HSPA14 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-3371556 | 0.0356320611636 | 0.5 | DNAJC2 HSPA14 | Cellular response to heat stress |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HSPA14 | DNAJC2 | 0.967 | 0.877 | hein_WMM bioplex (DNAJC2) bioplex_WMM hein (HSPA14) fraction |
| DNAJC2 | EIF2A | 0.691 | 0.715 | bioplex_WMM gupta_WMM fraction |
| HSPA14 | EIF2A | 0.665 | 0.701 | youn_WMM gupta_WMM fraction |
| DNAJC2 | DDX3X | 0.664 | 0.699 | bioplex (DNAJC2) fraction |
| EIF2A | DDX3X | 0.021 | 0.191 | youn (DDX3X) youn_WMM fraction treiber_WMM |
| HSPA14 | DDX3X | 0.0 | 0.008 | bioplex_WMM youn_WMM fraction |
Images
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Complex HuMAP2_02281 has an average edge precision of 0.532 which is ranked 2323 out of all 6965 complexes.
Related Complexes