hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02295

Confidence: Medium High

Genename	Protein Name	Links
BCL2L1	Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)	UniProt NCBI
BAD	Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)	UniProt NCBI
TRMO	tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O)	UniProt NCBI
BCL2L11	Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)	UniProt NCBI
BCL2	Apoptosis regulator Bcl-2	UniProt NCBI
RHPN2	Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-111453	1.51091283076e-10	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REAC:R-HSA-109606	2.74945671388e-07	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	Intrinsic Pathway for Apoptosis
WP:WP254	3.26731768958e-07	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	Apoptosis
KEGG:01521	3.86936610311e-07	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	EGFR tyrosine kinase inhibitor resistance
WP:WP1772	4.9900117021e-07	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	Apoptosis Modulation and Signaling
KEGG:04210	3.24115048953e-06	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	Apoptosis
KEGG:04215	6.80039367008e-06	0.5	BCL2L11 BCL2 BCL2L1	Apoptosis - multiple species
WP:WP2447	1.25967140138e-05	0.5	BAD BCL2 BCL2L1	Amyotrophic lateral sclerosis (ALS)
WP:WP286	1.7131668569e-05	0.5	BAD BCL2 BCL2L1	IL-3 Signaling Pathway
REAC:R-HSA-114452	2.40800825039e-05	0.5	BCL2L11 BCL2 BAD	Activation of BH3-only proteins
WP:WP3611	2.41794273383e-05	0.5	BCL2L11 BCL2 BCL2L1	Photodynamic therapy-induced AP-1 survival signaling.
GO:2001244	2.99853000209e-05	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	positive regulation of intrinsic apoptotic signaling pathway
KEGG:05014	3.4770637772e-05	0.5	BAD BCL2 BCL2L1	Amyotrophic lateral sclerosis (ALS)
REAC:R-HSA-109581	3.86525710038e-05	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	Apoptosis
REAC:R-HSA-5357801	4.14836354799e-05	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	Programmed Cell Death
GO:0001836	4.49707918505e-05	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	release of cytochrome c from mitochondria
REAC:R-HSA-844455	6.65030189148e-05	0.333333333333	BCL2 BCL2L1	The NLRP1 inflammasome
WP:WP4172	8.1191833253e-05	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	PI3K-Akt Signaling Pathway
WP:WP4216	8.49189157531e-05	0.5	BCL2L11 BCL2 BAD	Chromosomal and microsatellite instability in colorectal cancer
KEGG:01524	9.92621413242e-05	0.5	BAD BCL2 BCL2L1	Platinum drug resistance
KEGG:04151	0.00010854557604	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	PI3K-Akt signaling pathway
KEGG:05210	0.000147172017102	0.5	BCL2L11 BCL2 BAD	Colorectal cancer
GO:0046902	0.000154355035659	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	regulation of mitochondrial membrane permeability
KEGG:05145	0.000222353816754	0.5	BAD BCL2 BCL2L1	Toxoplasmosis
GO:0090559	0.000246130343849	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	regulation of membrane permeability
WP:WP710	0.000269213029719	0.5	BCL2L11 BCL2 BAD	DNA Damage Response (only ATM dependent)
KEGG:05162	0.000563363106539	0.5	BAD BCL2 BCL2L1	Measles
KEGG:05200	0.000619708787865	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	Pathways in cancer
KEGG:04140	0.000632078586851	0.5	BAD BCL2 BCL2L1	Autophagy - animal
WP:WP3657	0.000852627081304	0.333333333333	BCL2 BCL2L1	Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex
GO:0008637	0.000968898210955	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	apoptotic mitochondrial changes
WP:WP3872	0.00105843860426	0.333333333333	BCL2 BCL2L1	Regulation of Apoptosis by Parathyroid Hormone-related Protein
MIRNA:hsa-miR-16-1-3p	0.00127334227449	0.5	BCL2L11 BCL2 TRMO	hsa-miR-16-1-3p
WP:WP205	0.00128637745568	0.333333333333	BCL2L1 BAD	IL-7 Signaling Pathway
GO:2001235	0.00193921959428	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	positive regulation of apoptotic signaling pathway
GO:0007006	0.00201287714577	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	mitochondrial membrane organization
GO:2001242	0.00208860909913	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	regulation of intrinsic apoptotic signaling pathway
KEGG:05170	0.00211201253822	0.5	BAD BCL2 BCL2L1	Human immunodeficiency virus 1 infection
REAC:R-HSA-111447	0.00232260810736	0.333333333333	BCL2 BAD	Activation of BAD and translocation to mitochondria
MIRNA:hsa-miR-3120-3p	0.00238133708387	0.5	BCL2L11 BCL2L1 RHPN2	hsa-miR-3120-3p
WP:WP3981	0.00293450086565	0.333333333333	BCL2 BAD	miRNA regulation of prostate cancer signaling pathways
GO:0005741	0.00317351526138	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	mitochondrial outer membrane
WP:WP3941	0.00369881973951	0.333333333333	BCL2 BAD	Oxidative Damage
REAC:R-HSA-622312	0.00377982352449	0.333333333333	BCL2 BCL2L1	Inflammasomes
GO:0031968	0.00436089686659	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	organelle outer membrane
GO:0019867	0.00449563214179	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	outer membrane
WP:WP364	0.00477752328717	0.333333333333	BCL2L1 BAD	IL-6 signaling pathway
WP:WP4008	0.0050096749716	0.333333333333	BCL2 BAD	NO/cGMP/PKG mediated Neuroprotection
WP:WP1971	0.0050096749716	0.333333333333	BCL2 BAD	Integrated Cancer Pathway
GO:0010821	0.00506594708818	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	regulation of mitochondrion organization
GO:0001844	0.00661098268806	0.5	BCL2L11 BCL2 BAD	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
WP:WP304	0.00852373853417	0.333333333333	BCL2 BAD	Kit receptor signaling pathway
GO:0090199	0.0108183376095	0.5	BCL2L11 BCL2L1 BAD	regulation of release of cytochrome c from mitochondria
KEGG:04115	0.0124835568261	0.333333333333	BCL2 BCL2L1	p53 signaling pathway
KEGG:05168	0.0142962779924	0.5	BAD BCL2 BCL2L1	Herpes simplex virus 1 infection
WP:WP2034	0.014901555017	0.333333333333	BCL2L1 BAD	Leptin signaling pathway
WP:WP4298	0.0153070697985	0.333333333333	BCL2 BCL2L1	Viral Acute Myocarditis
KEGG:05212	0.0153684049392	0.333333333333	BCL2L1 BAD	Pancreatic cancer
WP:WP1438	0.0166465613198	0.166666666667	BCL2	Influenza A virus infection
KEGG:05220	0.0166952607135	0.333333333333	BCL2L1 BAD	Chronic myeloid leukemia
WP:WP4263	0.0187442252959	0.333333333333	BCL2L1 BAD	Pancreatic adenocarcinoma pathway
KEGG:04064	0.0190270141569	0.333333333333	BCL2 BCL2L1	NF-kappa B signaling pathway
WP:WP673	0.0196570281132	0.333333333333	BCL2L11 BAD	ErbB Signaling Pathway
GO:0051881	0.0207293189685	0.5	BAD BCL2 BCL2L1	regulation of mitochondrial membrane potential
WP:WP231	0.021066272601	0.333333333333	BCL2L1 BAD	TNF alpha Signaling Pathway
GO:0070059	0.0222806450818	0.5	BCL2L11 BCL2 BCL2L1	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0097193	0.023174580771	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	intrinsic apoptotic signaling pathway
GO:0051204	0.0239073169747	0.5	BCL2L11 BCL2 BAD	protein insertion into mitochondrial membrane
WP:WP4658	0.02454095485	0.333333333333	BCL2 BCL2L1	Small cell lung cancer
KEGG:05215	0.0246844798555	0.333333333333	BCL2 BAD	Prostate cancer
KEGG:01522	0.0246844798555	0.333333333333	BCL2 BAD	Endocrine resistance
KEGG:05222	0.0257907962007	0.333333333333	BCL2 BCL2L1	Small cell lung cancer
REAC:R-HSA-168643	0.0302745579484	0.333333333333	BCL2 BCL2L1	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REAC:R-HSA-193648	0.0302745579484	0.333333333333	BCL2L11 BAD	NRAGE signals death through JNK
GO:0097345	0.0312028564126	0.5	BCL2L11 BCL2 BAD	mitochondrial outer membrane permeabilization
KEGG:04722	0.0348461971614	0.333333333333	BCL2 BAD	Neurotrophin signaling pathway
GO:1902110	0.0353486827187	0.5	BCL2L11 BCL2 BAD	positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0006839	0.0364891183251	0.666666666667	BCL2L11 BAD BCL2 BCL2L1	mitochondrial transport
MIRNA:hsa-miR-184	0.0388499553328	0.333333333333	BCL2 BCL2L1	hsa-miR-184
GO:1902686	0.0398453744123	0.5	BCL2L11 BCL2 BAD	mitochondrial outer membrane permeabilization involved in programmed cell death
GO:0051400	0.0405595771497	0.333333333333	BCL2 BCL2L1	BH domain binding
GO:0051434	0.0405595771497	0.333333333333	BCL2 BCL2L1	BH3 domain binding
GO:0035794	0.0422297014162	0.5	BCL2L11 BCL2 BAD	positive regulation of mitochondrial membrane permeability
GO:0051205	0.0422297014162	0.5	BCL2L11 BCL2 BAD	protein insertion into membrane
GO:1902108	0.0422297014162	0.5	BCL2L11 BCL2 BAD	regulation of mitochondrial membrane permeability involved in apoptotic process
KEGG:04630	0.0444979624084	0.333333333333	BCL2 BCL2L1	JAK-STAT signaling pathway
GO:1905710	0.0447070305646	0.5	BCL2L11 BCL2 BAD	positive regulation of membrane permeability
REAC:R-HSA-204998	0.0499130144295	0.333333333333	BCL2L11 BAD	Cell death signalling via NRAGE, NRIF and NADE
CORUM:7275	0.0499726005494	0.166666666667	BCL2	BCL2-CISD2 complex
CORUM:1062	0.0499726005494	0.166666666667	BCL2	BAR-BCL2-CASP8 complex
CORUM:5526	0.0499726005494	0.166666666667	BCL2	CALM1-FKBP38-BCL2 complex
CORUM:5811	0.0499726005494	0.166666666667	BCL2	p53-BCL2 complex
CORUM:5812	0.0499726005494	0.166666666667	BCL2L1	p53-BCL2 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
BAD	BCL2L1	0.976	0.892	bioplex (BCL2L1) bioplex_WMM
BCL2	BCL2L1	0.831	0.778	bioplex (BCL2L1) bioplex_WMM
BCL2L11	BCL2L1	0.773	0.752	bioplex (BCL2L1,BCL2L11) bioplex_WMM
BCL2L11	RHPN2	0.731	0.736	bioplex (BCL2L11) bioplex_WMM
RHPN2	TRMO	0.149	0.41	bioplex (TRMO) bioplex_WMM
BCL2	BCL2L11	0.066	0.35	bioplex (BCL2L11) bioplex_WMM
BAD	BCL2	0.009	0.101	bioplex_WMM WMM_only
BCL2	RHPN2	0.009	0.096	bioplex_WMM WMM_only
BCL2L1	RHPN2	0.009	0.098	bioplex_WMM WMM_only
BAD	BCL2L11	0.008	0.068	bioplex_WMM WMM_only

Images

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Complex HuMAP2_02295 has an average edge precision of 0.428 which is ranked 3042 out of all 6965 complexes.

Related Complexes

Genename	Complexes
BCL2L1	HuMAP2_01477 HuMAP2_01697 HuMAP2_02045 HuMAP2_02295 HuMAP2_06589 HuMAP2_06641
BAD	HuMAP2_00315 HuMAP2_01477 HuMAP2_01697 HuMAP2_02045 HuMAP2_02295 HuMAP2_04311 HuMAP2_04651 HuMAP2_05206 HuMAP2_06018 HuMAP2_06641
TRMO	HuMAP2_01477 HuMAP2_02295 HuMAP2_05402 HuMAP2_06589 HuMAP2_06641
BCL2L11	HuMAP2_01477 HuMAP2_02295 HuMAP2_03520 HuMAP2_05402 HuMAP2_06589 HuMAP2_06641
BCL2	HuMAP2_01477 HuMAP2_01697 HuMAP2_02045 HuMAP2_02295 HuMAP2_06589 HuMAP2_06641
RHPN2	HuMAP2_01477 HuMAP2_02295 HuMAP2_03520 HuMAP2_05402 HuMAP2_06589 HuMAP2_06641

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_02295