hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02308
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PCCA | Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) | UniProt NCBI |
| PCCB | Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7057 | 1.67592346237e-06 | 1.0 | PCCA PCCB | Propionyl-CoA carboxylase |
| HP:0003353 | 1.00182980306e-05 | 1.0 | PCCA PCCB | Propionyl-CoA carboxylase deficiency |
| REAC:R-HSA-71032 | 1.67592346237e-05 | 1.0 | PCCA PCCB | Propionyl-CoA catabolism |
| REAC:R-HSA-3371599 | 3.51943927099e-05 | 1.0 | PCCA PCCB | Defective HLCS causes multiple carboxylase deficiency |
| REAC:R-HSA-3323169 | 4.69258569465e-05 | 1.0 | PCCA PCCB | Defects in biotin (Btn) metabolism |
| HP:0011695 | 5.00914901532e-05 | 1.0 | PCCA PCCB | Cerebellar hemorrhage |
| KEGG:00630 | 6.3465431699e-05 | 1.0 | PCCA PCCB | Glyoxylate and dicarboxylate metabolism |
| HP:0410066 | 7.01280862145e-05 | 1.0 | PCCA PCCB | Increased level of hippuric acid in urine |
| HP:0006846 | 7.01280862145e-05 | 1.0 | PCCA PCCB | Acute encephalopathy |
| KEGG:00640 | 8.184852226e-05 | 1.0 | PCCA PCCB | Propanoate metabolism |
| REAC:R-HSA-196780 | 9.21757904306e-05 | 1.0 | PCCA PCCB | Biotin transport and metabolism |
| HP:0003108 | 0.00015027447046 | 1.0 | PCCA PCCB | Hyperglycinuria |
| HP:0002154 | 0.00015027447046 | 1.0 | PCCA PCCB | Hyperglycinemia |
| KEGG:00280 | 0.000157715245211 | 1.0 | PCCA PCCB | Valine, leucine and isoleucine degradation |
| HP:0010895 | 0.000260475748797 | 1.0 | PCCA PCCB | Abnormal circulating glycine concentration |
| HP:0010894 | 0.000350640431072 | 1.0 | PCCA PCCB | Abnormal circulating serine family amino acid concentration |
| REAC:R-HSA-3296482 | 0.000351943927099 | 1.0 | PCCA PCCB | Defects in vitamin and cofactor metabolism |
| GO:0004658 | 0.000450823411379 | 1.0 | PCCA PCCB | propionyl-CoA carboxylase activity |
| HP:0031980 | 0.000634492208607 | 1.0 | PCCA PCCB | Abnormal urine carboxylic acid level |
| REAC:R-HSA-77289 | 0.000884887588134 | 1.0 | PCCA PCCB | Mitochondrial Fatty Acid Beta-Oxidation |
| KEGG:01200 | 0.000939726081777 | 1.0 | PCCA PCCB | Carbon metabolism |
| HP:0004396 | 0.00117214086958 | 1.0 | PCCA PCCB | Poor appetite |
| HP:0001987 | 0.00345631282057 | 1.0 | PCCA PCCB | Hyperammonemia |
| HP:0001733 | 0.00631486719198 | 1.0 | PCCA PCCB | Pancreatitis |
| REAC:R-HSA-5668914 | 0.00641543501397 | 1.0 | PCCA PCCB | Diseases of metabolism |
| HP:0001992 | 0.00652191201795 | 1.0 | PCCA PCCB | Organic aciduria |
| HP:0001944 | 0.00673229627659 | 1.0 | PCCA PCCB | Dehydration |
| GO:0016421 | 0.00676235117068 | 1.0 | PCCA PCCB | CoA carboxylase activity |
| HP:0001259 | 0.00877602907484 | 1.0 | PCCA PCCB | Coma |
| MIRNA:hsa-miR-455-5p | 0.00901918403126 | 1.0 | PCCA PCCB | hsa-miR-455-5p |
| GO:0016885 | 0.00946729163895 | 1.0 | PCCA PCCB | ligase activity, forming carbon-carbon bonds |
| HP:0002509 | 0.0100283163287 | 1.0 | PCCA PCCB | Limb hypertonia |
| REAC:R-HSA-196849 | 0.0100471611569 | 1.0 | PCCA PCCB | Metabolism of water-soluble vitamins and cofactors |
| HP:0001876 | 0.0116412623116 | 1.0 | PCCA PCCB | Pancytopenia |
| HP:0025356 | 0.0116412623116 | 1.0 | PCCA PCCB | Psychomotor retardation |
| HP:0001942 | 0.0124928176442 | 1.0 | PCCA PCCB | Metabolic acidosis |
| GO:0019626 | 0.0126230555186 | 1.0 | PCCA PCCB | short-chain fatty acid catabolic process |
| HP:0002170 | 0.0127833482871 | 1.0 | PCCA PCCB | Intracranial hemorrhage |
| HP:0002157 | 0.0133744278709 | 1.0 | PCCA PCCB | Azotemia |
| HP:0004364 | 0.0139788651854 | 1.0 | PCCA PCCB | Abnormal circulating nitrogen compound concentration |
| HP:0002789 | 0.0149105669023 | 1.0 | PCCA PCCB | Tachypnea |
| HP:0003112 | 0.0158723235132 | 1.0 | PCCA PCCB | Abnormality of serum amino acid level |
| GO:0006768 | 0.0162296428096 | 1.0 | PCCA PCCB | biotin metabolic process |
| HP:0000964 | 0.0165301917506 | 1.0 | PCCA PCCB | Eczema |
| REAC:R-HSA-8978868 | 0.0194876380205 | 1.0 | PCCA PCCB | Fatty acid metabolism |
| HP:0012091 | 0.0207579135195 | 1.0 | PCCA PCCB | Abnormality of pancreas physiology |
| HP:0004354 | 0.0222740159548 | 1.0 | PCCA PCCB | Abnormal circulating carboxylic acid concentration |
| HP:0012145 | 0.0226613901453 | 1.0 | PCCA PCCB | Abnormality of multiple cell lineages in the bone marrow |
| HP:0003355 | 0.0234461568244 | 1.0 | PCCA PCCB | Aminoaciduria |
| REAC:R-HSA-196854 | 0.024074640537 | 1.0 | PCCA PCCB | Metabolism of vitamins and cofactors |
| HP:0008936 | 0.0254665135939 | 1.0 | PCCA PCCB | Muscular hypotonia of the trunk |
| HP:0001875 | 0.0267188008477 | 1.0 | PCCA PCCB | Neutropenia |
| HP:0005561 | 0.0280011429956 | 1.0 | PCCA PCCB | Abnormality of bone marrow cell morphology |
| HP:0011991 | 0.0280011429956 | 1.0 | PCCA PCCB | Abnormal neutrophil count |
| HP:0001254 | 0.0293135400377 | 1.0 | PCCA PCCB | Lethargy |
| GO:0046459 | 0.0351642260875 | 1.0 | PCCA PCCB | short-chain fatty acid metabolic process |
| HP:0003128 | 0.0373181601641 | 1.0 | PCCA PCCB | Lactic acidosis |
| HP:0032309 | 0.0419466138543 | 1.0 | PCCA PCCB | Abnormal granulocyte count |
| HP:0012379 | 0.0457335305099 | 1.0 | PCCA PCCB | Abnormal enzyme/coenzyme activity |
| HP:0012072 | 0.047406586281 | 1.0 | PCCA PCCB | Aciduria |
| HP:0001943 | 0.0496840793666 | 1.0 | PCCA PCCB | Hypoglycemia |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PCCA | PCCB | 1.0 | 0.949 | bioplex (PCCA) bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_02308 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PCCA | HuMAP2_02308 HuMAP2_04069 HuMAP2_05729 HuMAP2_05918 |
| PCCB | HuMAP2_02308 HuMAP2_04069 |