hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02320
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | UniProt NCBI |
| UBA2 | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | UniProt NCBI |
| EEF1AKNMT | eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] | UniProt NCBI |
| ZNF451 | E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) | UniProt NCBI |
| AAAS | Aladin (Adracalin) | UniProt NCBI |
| UBE2I | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | UniProt NCBI |
| GCLC | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) | UniProt NCBI |
| SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | UniProt NCBI |
| PYROXD2 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC 1.-.-.-) | UniProt NCBI |
| NDC1 | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016925 | 1.9876426733e-10 | 0.7 | UBA2 SUMO2 NDC1 AAAS SAE1 UBE2I ZNF451 | protein sumoylation |
| REAC:R-HSA-3065678 | 7.49514718539e-10 | 0.4 | SUMO2 UBA2 SAE1 UBE2I | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 4.49273987549e-09 | 0.4 | SUMO2 UBA2 SAE1 UBE2I | Processing and activation of SUMO |
| REAC:R-HSA-2990846 | 9.19111247746e-08 | 0.6 | UBA2 SUMO2 NDC1 AAAS SAE1 UBE2I | SUMOylation |
| REAC:R-HSA-3065676 | 4.55671370693e-07 | 0.3 | UBA2 SAE1 SUMO2 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-4085377 | 6.686167013e-07 | 0.4 | UBE2I AAAS NDC1 SUMO2 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-4615885 | 2.37002884766e-06 | 0.4 | UBE2I AAAS NDC1 SUMO2 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 2.37002884766e-06 | 0.4 | UBE2I AAAS NDC1 SUMO2 | SUMOylation of RNA binding proteins |
| GO:0018205 | 5.11181727015e-06 | 0.7 | UBA2 SUMO2 NDC1 AAAS SAE1 UBE2I ZNF451 | peptidyl-lysine modification |
| REAC:R-HSA-4551638 | 1.42296493277e-05 | 0.4 | UBE2I AAAS NDC1 SUMO2 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3108214 | 2.03817095002e-05 | 0.4 | UBE2I AAAS NDC1 SUMO2 | SUMOylation of DNA damage response and repair proteins |
| CORUM:5756 | 3.01890677263e-05 | 0.2 | UBA2 SAE1 | SUA1-UBA2 complex |
| CORUM:5755 | 9.0534767973e-05 | 0.2 | UBA2 SAE1 | SUMO1-SUA1-UBA2 complex |
| KEGG:03013 | 0.000103028994671 | 0.4 | UBE2I AAAS NDC1 SUMO2 | RNA transport |
| GO:0044388 | 0.000108905457596 | 0.3 | UBA2 SAE1 UBE2I | small protein activating enzyme binding |
| REAC:R-HSA-3232142 | 0.000269898234756 | 0.3 | UBE2I AAAS NDC1 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-3108232 | 0.000620558627955 | 0.4 | UBE2I AAAS NDC1 SUMO2 | SUMO E3 ligases SUMOylate target proteins |
| GO:0032446 | 0.00143431823787 | 0.7 | UBA2 SUMO2 NDC1 AAAS SAE1 UBE2I ZNF451 | protein modification by small protein conjugation |
| KEGG:04120 | 0.00358449801405 | 0.3 | UBA2 SAE1 UBE2I | Ubiquitin mediated proteolysis |
| REAC:R-HSA-196791 | 0.00380880777617 | 0.2 | UBE2I SUMO2 | Vitamin D (calciferol) metabolism |
| GO:0070647 | 0.00724786690985 | 0.7 | UBA2 SUMO2 NDC1 AAAS SAE1 UBE2I ZNF451 | protein modification by small protein conjugation or removal |
| REAC:R-HSA-3232118 | 0.0114822352037 | 0.2 | UBE2I SUMO2 | SUMOylation of transcription factors |
| REAC:R-HSA-597592 | 0.0117594003776 | 0.6 | UBA2 SUMO2 NDC1 AAAS SAE1 UBE2I | Post-translational protein modification |
| GO:0018193 | 0.0121093775605 | 0.7 | UBA2 SUMO2 NDC1 AAAS SAE1 UBE2I ZNF451 | peptidyl-amino acid modification |
| GO:0019948 | 0.020287053512 | 0.2 | UBA2 SAE1 | SUMO activating enzyme activity |
| REAC:R-HSA-4090294 | 0.0213144720828 | 0.2 | UBE2I SUMO2 | SUMOylation of intracellular receptors |
| REAC:R-HSA-168333 | 0.0317883468809 | 0.2 | NDC1 AAAS | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168274 | 0.0317883468809 | 0.2 | NDC1 AAAS | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168271 | 0.0317883468809 | 0.2 | NDC1 AAAS | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-5619107 | 0.0317883468809 | 0.2 | NDC1 AAAS | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-170822 | 0.0317883468809 | 0.2 | NDC1 AAAS | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-180746 | 0.0365556262578 | 0.2 | NDC1 AAAS | Nuclear import of Rev protein |
| REAC:R-HSA-159227 | 0.0365556262578 | 0.2 | NDC1 AAAS | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180910 | 0.0365556262578 | 0.2 | NDC1 AAAS | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-159230 | 0.0390627070912 | 0.2 | NDC1 AAAS | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-165054 | 0.0390627070912 | 0.2 | NDC1 AAAS | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-3301854 | 0.04165196287 | 0.2 | NDC1 AAAS | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-176033 | 0.0443233043097 | 0.2 | NDC1 AAAS | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 0.0443233043097 | 0.2 | NDC1 AAAS | Interactions of Rev with host cellular proteins |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SAE1 | UBA2 | 0.988 | 0.901 | hein_WMM bioplex (UBA2) bioplex_WMM Guru youn_WMM hein (SAE1) gupta_WMM fraction |
| SAE1 | SUMO2 | 0.605 | 0.672 | hein_WMM bioplex_WMM youn_WMM hein (SAE1) gupta_WMM fraction |
| UBE2I | SUMO2 | 0.574 | 0.656 | hein_WMM bioplex (UBE2I) bioplex_WMM Guru youn_WMM hein (UBE2I) gupta_WMM fraction |
| UBE2I | UBA2 | 0.533 | 0.638 | hein_WMM bioplex (UBA2,UBE2I) bioplex_WMM Guru youn_WMM hein (UBE2I) gupta_WMM fraction |
| SAE1 | EEF1AKNMT | 0.179 | 0.438 | bioplex_WMM fraction |
| UBE2I | SAE1 | 0.07 | 0.35 | hein_WMM bioplex (UBE2I) bioplex_WMM Guru youn_WMM hein (UBE2I) gupta_WMM fraction |
| UBE2I | NDC1 | 0.04 | 0.268 | hein_WMM youn_WMM hein (UBE2I) gupta_WMM |
| GCLC | SAE1 | 0.031 | 0.238 | fraction |
| AAAS | NDC1 | 0.024 | 0.212 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PYROXD2 | UBA2 | 0.023 | 0.21 | fraction |
| UBE2I | ZNF451 | 0.02 | 0.184 | bioplex (UBE2I) bioplex_WMM youn_WMM |
| AAAS | UBE2I | 0.02 | 0.184 | hein_WMM youn_WMM hein (UBE2I) gupta_WMM |
| AAAS | SUMO2 | 0.01 | 0.13 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SUMO2 | NDC1 | 0.009 | 0.091 | hein_WMM youn_WMM gupta_WMM WMM_only |
| SUMO2 | UBA2 | 0.009 | 0.093 | hein_WMM bioplex (UBA2) bioplex_WMM youn_WMM gupta_WMM |
| ZNF451 | SUMO2 | 0.008 | 0.094 | bioplex_WMM youn_WMM WMM_only |
| ZNF451 | SAE1 | 0.008 | 0.085 | bioplex_WMM youn_WMM WMM_only |
| ZNF451 | UBA2 | 0.007 | 0.01 | bioplex_WMM youn_WMM WMM_only |
| AAAS | UBA2 | 0.007 | 0.005 | hein_WMM youn_WMM gupta_WMM WMM_only |
| AAAS | SAE1 | 0.007 | 0.003 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| UBA2 | NDC1 | 0.007 | 0.0 | hein_WMM youn_WMM gupta_WMM WMM_only |
| UBE2I | EEF1AKNMT | 0.007 | 0.001 | gupta_WMM WMM_only |
| AAAS | ZNF451 | 0.007 | 0.001 | youn_WMM WMM_only |
| ZNF451 | NDC1 | 0.007 | 0.001 | youn_WMM WMM_only |
| SUMO2 | EEF1AKNMT | 0.007 | 0.0 | bioplex_WMM WMM_only |
| SAE1 | NDC1 | 0.007 | 0.002 | hein_WMM youn_WMM WMM_only |
| EEF1AKNMT | NDC1 | 0.006 | 0.005 | bioplex_WMM WMM_only |
| GCLC | SUMO2 | 0.005 | 0.009 | bioplex (GCLC) |
| EEF1AKNMT | UBA2 | 0.004 | 0.012 | fraction |
| AAAS | EEF1AKNMT | 0.003 | 0.009 | bioplex_WMM WMM_only |
| GCLC | UBA2 | 0.003 | 0.011 | fraction |
| GCLC | UBE2I | 0.0 | 0.005 | fraction |
Images
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Complex HuMAP2_02320 has an average edge precision of 0.172 which is ranked 6502 out of all 6965 complexes.
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