hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02325
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta) | UniProt NCBI |
| PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) | UniProt NCBI |
| PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PP2A B subunit isoform B'-epsilon) (PP2A B subunit isoform B56-epsilon) (PP2A B subunit isoform PR61-epsilon) (PP2A B subunit isoform R5-epsilon) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5467340 | 1.63653275606e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-4839735 | 1.63653275606e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| REAC:R-HSA-5467337 | 1.63653275606e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-4839748 | 1.63653275606e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | AMER1 mutants destabilize the destruction complex |
| REAC:R-HSA-5467348 | 1.63653275606e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Truncations of AMER1 destabilize the destruction complex |
| REAC:R-HSA-4839744 | 1.63653275606e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | truncated APC mutants destabilize the destruction complex |
| REAC:R-HSA-5339716 | 2.04566594508e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Misspliced GSK3beta mutants stabilize beta-catenin |
| REAC:R-HSA-5358747 | 2.04566594508e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | S33 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358751 | 2.04566594508e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | S45 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-5358752 | 2.04566594508e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | T41 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-4839743 | 2.04566594508e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| REAC:R-HSA-5358749 | 2.04566594508e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | S37 mutants of beta-catenin aren't phosphorylated |
| REAC:R-HSA-432142 | 3.05725899484e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Platelet sensitization by LDL |
| REAC:R-HSA-389513 | 3.05725899484e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | CTLA4 inhibitory signaling |
| REAC:R-HSA-196299 | 3.05725899484e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Beta-catenin phosphorylation cascade |
| WP:WP500 | 5.43365608036e-07 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Glycogen Synthesis and Degradation |
| REAC:R-HSA-5673000 | 1.64282711281e-06 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | RAF activation |
| REAC:R-HSA-4791275 | 1.82536345868e-06 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Signaling by WNT in cancer |
| REAC:R-HSA-4641262 | 1.82536345868e-06 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| KEGG:03015 | 3.30002227102e-06 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | mRNA surveillance pathway |
| REAC:R-HSA-5675221 | 3.49336799851e-06 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Negative regulation of MAPK pathway |
| KEGG:04114 | 5.96891558343e-06 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Oocyte meiosis |
| KEGG:04071 | 6.31321421816e-06 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Sphingolipid signaling pathway |
| KEGG:04152 | 6.85409597589e-06 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | AMPK signaling pathway |
| KEGG:04728 | 8.66024288846e-06 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Dopaminergic synapse |
| WP:WP399 | 9.49666017649e-06 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Wnt Signaling Pathway and Pluripotency |
| KEGG:04261 | 1.05104157597e-05 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-388841 | 1.11518017806e-05 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Costimulation by the CD28 family |
| REAC:R-HSA-6811558 | 2.35561805552e-05 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 3.16066628437e-05 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-418346 | 3.28880140401e-05 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Platelet homeostasis |
| CORUM:5876 | 3.35555483123e-05 | 0.666666666667 | PPP2R1A PPP2R1B | PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex |
| REAC:R-HSA-195253 | 3.98163024387e-05 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Degradation of beta-catenin by the destruction complex |
| REAC:R-HSA-141444 | 5.64603800841e-05 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 5.64603800841e-05 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Amplification of signal from the kinetochores |
| GO:0000159 | 8.80032001664e-05 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | protein phosphatase type 2A complex |
| REAC:R-HSA-69618 | 8.92382428809e-05 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Mitotic Spindle Checkpoint |
| REAC:R-HSA-2500257 | 0.000126264796487 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Resolution of Sister Chromatid Cohesion |
| KEGG:04151 | 0.00013397544306 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | PI3K-Akt signaling pathway |
| REAC:R-HSA-163767 | 0.000140571869389 | 0.666666666667 | PPP2R1A PPP2R1B | PP2A-mediated dephosphorylation of key metabolic factors |
| KEGG:05165 | 0.000150762444884 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Human papillomavirus infection |
| REAC:R-HSA-5663220 | 0.00017233319357 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | RHO GTPases Activate Formins |
| WP:WP3932 | 0.000177999256178 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP4172 | 0.000251129143237 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | PI3K-Akt Signaling Pathway |
| REAC:R-HSA-2465910 | 0.000301184970683 | 0.666666666667 | PPP2R1A PPP2R1B | MASTL Facilitates Mitotic Progression |
| REAC:R-HSA-9634600 | 0.000441698392473 | 0.666666666667 | PPP2R1A PPP2R1B | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism |
| REAC:R-HSA-2467813 | 0.000451723953992 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.000513949964862 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.000513949964862 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Mitotic Anaphase |
| REAC:R-HSA-113501 | 0.000521983812065 | 0.666666666667 | PPP2R1A PPP2R1B | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-202670 | 0.000521983812065 | 0.666666666667 | PPP2R1A PPP2R1B | ERKs are inactivated |
| REAC:R-HSA-2555396 | 0.000522107900813 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-5673001 | 0.00053868184134 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.000581643074171 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | MAPK1/MAPK3 signaling |
| KEGG:04730 | 0.000615711573085 | 0.666666666667 | PPP2R1A PPP2R1B | Long-term depression |
| REAC:R-HSA-9607240 | 0.000693937096245 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | FLT3 Signaling |
| REAC:R-HSA-201681 | 0.000808797867084 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | TCF dependent signaling in response to WNT |
| GO:0008287 | 0.000829990966275 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | protein serine/threonine phosphatase complex |
| GO:1903293 | 0.000829990966275 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | phosphatase complex |
| REAC:R-HSA-1257604 | 0.000842184933696 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | PIP3 activates AKT signaling |
| REAC:R-HSA-449836 | 0.000864945777315 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Other interleukin signaling |
| REAC:R-HSA-5683057 | 0.00097245114269 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | MAPK family signaling cascades |
| KEGG:04350 | 0.00134028141892 | 0.666666666667 | PPP2R1A PPP2R1B | TGF-beta signaling pathway |
| REAC:R-HSA-9006925 | 0.00134762672661 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Intracellular signaling by second messengers |
| REAC:R-HSA-113510 | 0.00154525199441 | 0.666666666667 | PPP2R1A PPP2R1B | E2F mediated regulation of DNA replication |
| REAC:R-HSA-198753 | 0.00154525199441 | 0.666666666667 | PPP2R1A PPP2R1B | ERK/MAPK targets |
| REAC:R-HSA-180024 | 0.00169234301901 | 0.666666666667 | PPP2R1A PPP2R1B | DARPP-32 events |
| KEGG:05142 | 0.0017077231529 | 0.666666666667 | PPP2R1A PPP2R1B | Chagas disease (American trypanosomiasis) |
| REAC:R-HSA-69620 | 0.00175293114833 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Cell Cycle Checkpoints |
| REAC:R-HSA-198725 | 0.00200655101382 | 0.666666666667 | PPP2R1A PPP2R1B | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-69273 | 0.00200655101382 | 0.666666666667 | PPP2R1A PPP2R1B | Cyclin A/B1/B2 associated events during G2/M transition |
| GO:0019888 | 0.00212751596192 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | protein phosphatase regulator activity |
| REAC:R-HSA-195258 | 0.00218937240413 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | RHO GTPase Effectors |
| REAC:R-HSA-195721 | 0.00221076692273 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Signaling by WNT |
| REAC:R-HSA-5663202 | 0.00284240562301 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Diseases of signal transduction |
| REAC:R-HSA-450282 | 0.00310931782116 | 0.666666666667 | PPP2R1A PPP2R1B | MAPK targets/ Nuclear events mediated by MAP kinases |
| GO:0019208 | 0.00360649647245 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | phosphatase regulator activity |
| REAC:R-HSA-6804757 | 0.00397787610966 | 0.666666666667 | PPP2R1A PPP2R1B | Regulation of TP53 Degradation |
| REAC:R-HSA-68886 | 0.00398320383305 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | M Phase |
| KEGG:05160 | 0.00408648948727 | 0.666666666667 | PPP2R1A PPP2R1B | Hepatitis C |
| REAC:R-HSA-6806003 | 0.00421167999129 | 0.666666666667 | PPP2R1A PPP2R1B | Regulation of TP53 Expression and Degradation |
| KEGG:04390 | 0.00445520604942 | 0.666666666667 | PPP2R1A PPP2R1B | Hippo signaling pathway |
| KEGG:04530 | 0.00464549646756 | 0.666666666667 | PPP2R1A PPP2R1B | Tight junction |
| REAC:R-HSA-69236 | 0.005754414243 | 0.666666666667 | PPP2R1A PPP2R1B | G1 Phase |
| REAC:R-HSA-69231 | 0.005754414243 | 0.666666666667 | PPP2R1A PPP2R1B | Cyclin D associated events in G1 |
| REAC:R-HSA-194315 | 0.00591618280835 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Signaling by Rho GTPases |
| MIRNA:hsa-miR-3138 | 0.00867456475437 | 0.666666666667 | PPP2R1A PPP2R5E | hsa-miR-3138 |
| REAC:R-HSA-449147 | 0.00988151966016 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Signaling by Interleukins |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Cell Cycle, Mitotic |
| REAC:R-HSA-109582 | 0.0114744505078 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Hemostasis |
| REAC:R-HSA-450294 | 0.0130404028432 | 0.666666666667 | PPP2R1A PPP2R1B | MAP kinase activation |
| REAC:R-HSA-70171 | 0.0143204798819 | 0.666666666667 | PPP2R1A PPP2R1B | Glycolysis |
| REAC:R-HSA-448424 | 0.015660289467 | 0.666666666667 | PPP2R1A PPP2R1B | Interleukin-17 signaling |
| REAC:R-HSA-187037 | 0.0175395775792 | 0.666666666667 | PPP2R1A PPP2R1B | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Cell Cycle |
| REAC:R-HSA-1280218 | 0.0202947578047 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Adaptive Immune System |
| REAC:R-HSA-168142 | 0.022155781492 | 0.666666666667 | PPP2R1A PPP2R1B | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-70326 | 0.022155781492 | 0.666666666667 | PPP2R1A PPP2R1B | Glucose metabolism |
| REAC:R-HSA-168176 | 0.022155781492 | 0.666666666667 | PPP2R1A PPP2R1B | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 0.022155781492 | 0.666666666667 | PPP2R1A PPP2R1B | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-975138 | 0.0232544758505 | 0.666666666667 | PPP2R1A PPP2R1B | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.0238137546255 | 0.666666666667 | PPP2R1A PPP2R1B | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.0238137546255 | 0.666666666667 | PPP2R1A PPP2R1B | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-111885 | 0.0243796532655 | 0.666666666667 | PPP2R1A PPP2R1B | Opioid Signalling |
| REAC:R-HSA-1280215 | 0.0245091821355 | 1.0 | PPP2R1A PPP2R1B PPP2R5E | Cytokine Signaling in Immune system |
| REAC:R-HSA-166058 | 0.0261170593829 | 0.666666666667 | PPP2R1A PPP2R1B | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168138 | 0.0261170593829 | 0.666666666667 | PPP2R1A PPP2R1B | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168188 | 0.0261170593829 | 0.666666666667 | PPP2R1A PPP2R1B | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168164 | 0.0267094284906 | 0.666666666667 | PPP2R1A PPP2R1B | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166520 | 0.0273084129672 | 0.666666666667 | PPP2R1A PPP2R1B | Signaling by NTRKs |
| REAC:R-HSA-168179 | 0.0279140119136 | 0.666666666667 | PPP2R1A PPP2R1B | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.0279140119136 | 0.666666666667 | PPP2R1A PPP2R1B | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-937061 | 0.0285262244305 | 0.666666666667 | PPP2R1A PPP2R1B | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.0285262244305 | 0.666666666667 | PPP2R1A PPP2R1B | MyD88-independent TLR4 cascade |
| REAC:R-HSA-163685 | 0.03104119222 | 0.666666666667 | PPP2R1A PPP2R1B | Integration of energy metabolism |
| REAC:R-HSA-166016 | 0.0459783176444 | 0.666666666667 | PPP2R1A PPP2R1B | Toll Like Receptor 4 (TLR4) Cascade |
| CORUM:1131 | 0.0499776345577 | 0.333333333333 | PPP2R1A | RFC2-RIalpha complex |
| CORUM:1132 | 0.0499776345577 | 0.333333333333 | PPP2R1A | RFC2-RIalpha complex |
| CORUM:1543 | 0.0499776345577 | 0.333333333333 | PPP2R1A | PPP2CA-PPP2R1A complex |
| CORUM:6180 | 0.0499776345577 | 0.333333333333 | PPP2R1A | PPP2R1A-PPP2R3B complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPP2R1B | PPP2R1A | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo fraction boldt_WMM |
| PPP2R5E | PPP2R1A | 0.973 | 0.886 | hein_WMM bioplex_WMM Guru boldt (PPP2R1A) hein (PPP2R1A) fraction boldt_WMM |
| PPP2R5E | PPP2R1B | 0.172 | 0.431 | hein_WMM bioplex_WMM Guru fraction |
Images
Click to enlarge
Complex HuMAP2_02325 has an average edge precision of 0.755 which is ranked 1118 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PPP2R1B | HuMAP2_02007 HuMAP2_02325 HuMAP2_02930 HuMAP2_04458 |
| PPP2R1A | HuMAP2_02007 HuMAP2_02325 HuMAP2_04458 HuMAP2_05962 |
| PPP2R5E | HuMAP2_01267 HuMAP2_01788 HuMAP2_02007 HuMAP2_02325 HuMAP2_04458 |