hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02326
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EXOSC10 | Exosome component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) | UniProt NCBI |
| EXOSC1 | Exosome complex component CSL4 (Exosome component 1) | UniProt NCBI |
| MPHOSPH6 | M-phase phosphoprotein 6 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7443 | 4.95783789704e-08 | 1.0 | EXOSC1 EXOSC10 MPHOSPH6 | Exosome |
| KEGG:03018 | 2.11408804451e-06 | 1.0 | EXOSC1 EXOSC10 MPHOSPH6 | RNA degradation |
| GO:0000176 | 5.08584025729e-05 | 1.0 | EXOSC1 EXOSC10 MPHOSPH6 | nuclear exosome (RNase complex) |
| GO:0000178 | 0.000183816797871 | 1.0 | EXOSC1 EXOSC10 MPHOSPH6 | exosome (RNase complex) |
| GO:1905354 | 0.000183816797871 | 1.0 | EXOSC1 EXOSC10 MPHOSPH6 | exoribonuclease complex |
| CORUM:789 | 0.000184505937338 | 0.666666666667 | EXOSC1 EXOSC10 | Exosome |
| REAC:R-HSA-6791226 | 0.00043699470959 | 1.0 | EXOSC1 EXOSC10 MPHOSPH6 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 0.000513949964862 | 1.0 | EXOSC1 EXOSC10 MPHOSPH6 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 0.000599447561444 | 1.0 | EXOSC1 EXOSC10 MPHOSPH6 | rRNA processing |
| REAC:R-HSA-8953854 | 0.0206735000409 | 1.0 | EXOSC1 EXOSC10 MPHOSPH6 | Metabolism of RNA |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MPHOSPH6 | EXOSC1 | 1.0 | 0.949 | hein_WMM bioplex (EXOSC1) bioplex_WMM youn_WMM hein (EXOSC1) Malo gupta_WMM fraction |
| EXOSC1 | EXOSC10 | 1.0 | 0.949 | hein_WMM youn (EXOSC10) bioplex (EXOSC1) bioplex_WMM Guru youn_WMM hein (EXOSC1) Malo gupta_WMM fraction |
| MPHOSPH6 | EXOSC10 | 0.993 | 0.918 | hein_WMM youn (EXOSC10) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
Images
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Complex HuMAP2_02326 has an average edge precision of 0.939 which is ranked 403 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EXOSC10 | HuMAP2_02326 HuMAP2_03073 HuMAP2_05790 |
| EXOSC1 | HuMAP2_02326 HuMAP2_03073 HuMAP2_05790 |
| MPHOSPH6 | HuMAP2_01835 HuMAP2_02326 HuMAP2_03073 HuMAP2_05790 |