hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02338
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATG14 | Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) | UniProt NCBI |
| PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) | UniProt NCBI |
| NRBF2 | Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR) | UniProt NCBI |
| BECN1 | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa] | UniProt NCBI |
| PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035032 | 4.91515675326e-14 | 1.0 | PIK3R4 BECN1 PIK3C3 NRBF2 ATG14 | phosphatidylinositol 3-kinase complex, class III |
| GO:0005942 | 3.48189704401e-10 | 1.0 | PIK3R4 BECN1 PIK3C3 NRBF2 ATG14 | phosphatidylinositol 3-kinase complex |
| KEGG:04140 | 2.50752636339e-09 | 1.0 | PIK3R4 BECN1 PIK3C3 NRBF2 ATG14 | Autophagy - animal |
| WP:WP4577 | 1.1127214073e-08 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway |
| CORUM:6472 | 1.35119464053e-08 | 0.6 | PIK3R4 PIK3C3 BECN1 | Bcl-2-Beclin1-UVRAG-PI(3)KC3 complex |
| REAC:R-HSA-1632852 | 8.09278526697e-07 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | Macroautophagy |
| GO:0034271 | 9.08185760231e-07 | 0.6 | PIK3R4 PIK3C3 BECN1 | phosphatidylinositol 3-kinase complex, class III, type I |
| GO:0034272 | 9.08185760231e-07 | 0.6 | PIK3R4 PIK3C3 BECN1 | phosphatidylinositol 3-kinase complex, class III, type II |
| REAC:R-HSA-9612973 | 1.60607455481e-06 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | Autophagy |
| KEGG:04136 | 3.87694214149e-06 | 0.6 | PIK3R4 PIK3C3 BECN1 | Autophagy - other |
| GO:0042149 | 4.983554895e-06 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | cellular response to glucose starvation |
| CORUM:429 | 6.70868171695e-06 | 0.4 | PIK3C3 PIK3R4 | Phosphatidylinositol 3-kinase complex (PIK3C3, PIK3R4) |
| GO:0019898 | 3.43858823717e-05 | 1.0 | PIK3R4 BECN1 PIK3C3 NRBF2 ATG14 | extrinsic component of membrane |
| GO:0061695 | 3.59850228871e-05 | 1.0 | PIK3R4 BECN1 PIK3C3 NRBF2 ATG14 | transferase complex, transferring phosphorus-containing groups |
| CORUM:6816 | 4.0241279111e-05 | 0.4 | PIK3C3 ATG14 | ULK1-ATG13-ATG14-PIK3C3 complex |
| WP:WP615 | 7.5737611324e-05 | 0.6 | BECN1 PIK3C3 ATG14 | Senescence and Autophagy in Cancer |
| KEGG:04371 | 0.000264979384683 | 0.6 | PIK3R4 PIK3C3 BECN1 | Apelin signaling pathway |
| GO:0009267 | 0.000475835425563 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | cellular response to starvation |
| KEGG:05167 | 0.000625511303776 | 0.6 | BECN1 PIK3C3 ATG14 | Kaposi sarcoma-associated herpesvirus infection |
| GO:0061919 | 0.000639961088829 | 1.0 | PIK3R4 BECN1 PIK3C3 NRBF2 ATG14 | process utilizing autophagic mechanism |
| GO:0006914 | 0.000639961088829 | 1.0 | PIK3R4 BECN1 PIK3C3 NRBF2 ATG14 | autophagy |
| REAC:R-HSA-1660517 | 0.000741476933235 | 0.4 | PIK3C3 PIK3R4 | Synthesis of PIPs at the late endosome membrane |
| GO:0042594 | 0.000753186291624 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | response to starvation |
| WP:WP2509 | 0.000769338921543 | 0.4 | ATG14 BECN1 | Nanoparticle triggered autophagic cell death |
| REAC:R-HSA-8953897 | 0.00083024651806 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | Cellular responses to external stimuli |
| GO:0031669 | 0.00155534683144 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | cellular response to nutrient levels |
| REAC:R-HSA-1660516 | 0.00161668141155 | 0.4 | PIK3C3 PIK3R4 | Synthesis of PIPs at the early endosome membrane |
| REAC:R-HSA-1660514 | 0.00183199274719 | 0.4 | PIK3C3 PIK3R4 | Synthesis of PIPs at the Golgi membrane |
| GO:0031668 | 0.00213856230812 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | cellular response to extracellular stimulus |
| REAC:R-HSA-5668599 | 0.00230284247734 | 0.4 | PIK3C3 PIK3R4 | RHO GTPases Activate NADPH Oxidases |
| GO:0000407 | 0.00235581550516 | 0.6 | BECN1 PIK3C3 ATG14 | phagophore assembly site |
| REAC:R-HSA-109704 | 0.00472180750517 | 0.4 | PIK3C3 PIK3R4 | PI3K Cascade |
| GO:0071496 | 0.00488578599782 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | cellular response to external stimulus |
| GO:0031667 | 0.00608750012464 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | response to nutrient levels |
| REAC:R-HSA-112399 | 0.00625202329777 | 0.4 | PIK3C3 PIK3R4 | IRS-mediated signalling |
| REAC:R-HSA-2428924 | 0.0075397219523 | 0.4 | PIK3C3 PIK3R4 | IGF1R signaling cascade |
| REAC:R-HSA-2428928 | 0.0075397219523 | 0.4 | PIK3C3 PIK3R4 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-2404192 | 0.00799559968784 | 0.4 | PIK3C3 PIK3R4 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| GO:0009991 | 0.00812559735038 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | response to extracellular stimulus |
| REAC:R-HSA-74751 | 0.00846479084427 | 0.4 | PIK3C3 PIK3R4 | Insulin receptor signalling cascade |
| GO:1990234 | 0.0112296002627 | 1.0 | PIK3R4 BECN1 PIK3C3 NRBF2 ATG14 | transferase complex |
| WP:WP710 | 0.0176422318434 | 0.4 | PIK3C3 PIK3R4 | DNA Damage Response (only ATM dependent) |
| GO:0016236 | 0.0210321541014 | 0.8 | PIK3R4 BECN1 PIK3C3 ATG14 | macroautophagy |
| REAC:R-HSA-74752 | 0.0229182830201 | 0.4 | PIK3C3 PIK3R4 | Signaling by Insulin receptor |
| WP:WP3915 | 0.0250517914711 | 0.4 | PIK3C3 PIK3R4 | Angiopoietin Like Protein 8 Regulatory Pathway |
| WP:WP51 | 0.0283719124097 | 0.4 | PIK3C3 PIK3R4 | Regulation of Actin Cytoskeleton |
| GO:0098796 | 0.0328678033498 | 1.0 | PIK3R4 BECN1 PIK3C3 NRBF2 ATG14 | membrane protein complex |
| WP:WP481 | 0.0385448371419 | 0.4 | PIK3C3 PIK3R4 | Insulin Signaling |
| REAC:R-HSA-1483255 | 0.0401214552357 | 0.4 | PIK3C3 PIK3R4 | PI Metabolism |
| GO:0030242 | 0.0450641792523 | 0.4 | PIK3C3 PIK3R4 | autophagy of peroxisome |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NRBF2 | BECN1 | 1.0 | 0.949 | hein_WMM bioplex (NRBF2) bioplex_WMM youn_WMM hein (BECN1) |
| NRBF2 | PIK3C3 | 1.0 | 0.949 | hein_WMM bioplex (NRBF2) bioplex_WMM youn_WMM gupta_WMM |
| NRBF2 | ATG14 | 0.998 | 0.939 | hein_WMM bioplex (ATG14,NRBF2) bioplex_WMM |
| ATG14 | BECN1 | 0.998 | 0.936 | hein_WMM bioplex (ATG14) bioplex_WMM hein (BECN1) |
| PIK3C3 | PIK3R4 | 0.996 | 0.925 | hein_WMM bioplex_WMM youn_WMM Malo fraction |
| PIK3C3 | ATG14 | 0.855 | 0.793 | hein_WMM bioplex (ATG14) bioplex_WMM |
| NRBF2 | PIK3R4 | 0.773 | 0.752 | hein_WMM bioplex (NRBF2) bioplex_WMM youn_WMM |
| PIK3C3 | BECN1 | 0.326 | 0.515 | hein_WMM bioplex_WMM youn_WMM hein (BECN1) |
| ATG14 | PIK3R4 | 0.129 | 0.399 | hein_WMM bioplex (ATG14) bioplex_WMM |
| BECN1 | PIK3R4 | 0.101 | 0.364 | hein_WMM bioplex_WMM youn_WMM hein (BECN1) |
Images
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Complex HuMAP2_02338 has an average edge precision of 0.752 which is ranked 1132 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATG14 | HuMAP2_02338 HuMAP2_04661 |
| PIK3C3 | HuMAP2_02338 HuMAP2_04661 |
| NRBF2 | HuMAP2_00914 HuMAP2_02338 HuMAP2_02669 HuMAP2_04661 |
| BECN1 | HuMAP2_02338 HuMAP2_04661 |
| PIK3R4 | HuMAP2_02338 HuMAP2_04661 |