hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02340
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UTP4 | U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component) | UniProt NCBI |
| NOL7 | Nucleolar protein 7 (Nucleolar protein of 27 kDa) | UniProt NCBI |
| HEATR1 | HEAT repeat-containing protein 1 (Protein BAP28) (U3 small nucleolar RNA-associated protein 10 homolog) [Cleaved into: HEAT repeat-containing protein 1, N-terminally processed] | UniProt NCBI |
| WDR75 | WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog) | UniProt NCBI |
| NOL11 | Nucleolar protein 11 | UniProt NCBI |
| UTP15 | U3 small nucleolar RNA-associated protein 15 homolog | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6790901 | 8.77427940368e-10 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | rRNA modification in the nucleus and cytosol |
| REAC:R-HSA-6791226 | 2.44317380739e-07 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 3.20449539048e-07 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 4.14453936466e-07 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | rRNA processing |
| KEGG:03008 | 4.54936912922e-07 | 0.666666666667 | HEATR1 UTP15 UTP4 WDR75 | Ribosome biogenesis in eukaryotes |
| GO:0034455 | 1.81637152046e-06 | 0.5 | HEATR1 NOL11 UTP4 | t-UTP complex |
| GO:0045943 | 2.18611257075e-06 | 0.666666666667 | HEATR1 UTP15 NOL11 WDR75 | positive regulation of transcription by RNA polymerase I |
| GO:0006356 | 8.66795236882e-06 | 0.666666666667 | HEATR1 UTP15 NOL11 WDR75 | regulation of transcription by RNA polymerase I |
| GO:0006364 | 5.93143067578e-05 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | rRNA processing |
| GO:0016072 | 7.66174643411e-05 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | rRNA metabolic process |
| REAC:R-HSA-8953854 | 0.000150175559311 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | Metabolism of RNA |
| GO:2000234 | 0.000152436922042 | 0.5 | HEATR1 UTP15 WDR75 | positive regulation of rRNA processing |
| GO:0090070 | 0.000152436922042 | 0.5 | HEATR1 UTP15 WDR75 | positive regulation of ribosome biogenesis |
| GO:0006360 | 0.000165563014397 | 0.666666666667 | HEATR1 UTP15 NOL11 WDR75 | transcription by RNA polymerase I |
| GO:0042254 | 0.000277631504382 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | ribosome biogenesis |
| GO:2000232 | 0.00039905855691 | 0.5 | HEATR1 UTP15 WDR75 | regulation of rRNA processing |
| GO:0090069 | 0.000518697707158 | 0.5 | HEATR1 UTP15 WDR75 | regulation of ribosome biogenesis |
| GO:0005730 | 0.000793435083069 | 1.0 | NOL7 WDR75 NOL11 HEATR1 UTP15 UTP4 | nucleolus |
| GO:0034470 | 0.00120907776661 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | ncRNA processing |
| GO:0022613 | 0.00270779091032 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | ribonucleoprotein complex biogenesis |
| GO:0034660 | 0.00405016747169 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | ncRNA metabolic process |
| GO:0044452 | 0.0109703973512 | 0.666666666667 | NOL11 UTP15 UTP4 HEATR1 | nucleolar part |
| MIRNA:hsa-miR-16-5p | 0.0146926265904 | 0.833333333333 | NOL11 HEATR1 UTP15 UTP4 WDR75 | hsa-miR-16-5p |
| GO:0030490 | 0.0178456165824 | 0.5 | HEATR1 NOL11 UTP4 | maturation of SSU-rRNA |
| GO:0003723 | 0.0386338629612 | 1.0 | NOL7 WDR75 NOL11 HEATR1 UTP15 UTP4 | RNA binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UTP4 | NOL11 | 0.916 | 0.839 | bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| UTP15 | UTP4 | 0.57 | 0.656 | hein_WMM bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| UTP15 | NOL11 | 0.428 | 0.576 | bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| UTP4 | WDR75 | 0.398 | 0.559 | bioplex (UTP4) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| HEATR1 | UTP15 | 0.237 | 0.47 | bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| UTP15 | NOL7 | 0.06 | 0.336 | bioplex (NOL7) bioplex_WMM youn_WMM treiber_WMM |
| WDR75 | NOL7 | 0.048 | 0.295 | bioplex (NOL7) bioplex_WMM youn_WMM |
| UTP15 | WDR75 | 0.013 | 0.151 | bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| WDR75 | NOL11 | 0.009 | 0.101 | bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| NOL7 | NOL11 | 0.008 | 0.068 | bioplex (NOL7) bioplex_WMM youn_WMM |
| HEATR1 | UTP4 | 0.008 | 0.024 | bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| HEATR1 | NOL7 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only boldt_WMM |
| HEATR1 | NOL11 | 0.007 | 0.008 | bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| UTP4 | NOL7 | 0.006 | 0.004 | bioplex (NOL7,UTP4) bioplex_WMM youn_WMM treiber_WMM |
| HEATR1 | WDR75 | 0.0 | 0.001 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_02340 has an average edge precision of 0.273 which is ranked 4984 out of all 6965 complexes.
Related Complexes