hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02343
Confidence: Medium  
ProteinsGenename | Protein Name | Links |
---|---|---|
E2F1 | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | UniProt   NCBI |
TFDP2 | Transcription factor Dp-2 (E2F dimerization partner 2) | UniProt   NCBI |
RB1 | Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110) | UniProt   NCBI |
E2F4 | Transcription factor E2F4 (E2F-4) | UniProt   NCBI |
E2F5 | Transcription factor E2F5 (E2F-5) | UniProt   NCBI |
E2F2 | Transcription factor E2F2 (E2F-2) | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  REAC:R-HSA-69231 | 5.67783245944e-14 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | Cyclin D associated events in G1 |
  REAC:R-HSA-69236 | 5.67783245944e-14 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | G1 Phase |
  WP:WP179 | 8.09532151655e-12 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | Cell Cycle |
  KEGG:04110 | 1.11652254558e-11 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | Cell cycle |
  REAC:R-HSA-453279 | 1.36793220389e-10 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | Mitotic G1-G1/S phases |
  REAC:R-HSA-1362300 | 2.18078791174e-09 | 0.666666666667 | TFDP2 E2F5 E2F4 E2F1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
  REAC:R-HSA-69202 | 4.37815496425e-09 | 0.833333333333 | TFDP2 E2F5 RB1 E2F1 E2F4 | Cyclin E associated events during G1/S transition |
  REAC:R-HSA-1362277 | 4.64286129501e-09 | 0.666666666667 | TFDP2 E2F5 E2F4 E2F1 | Transcription of E2F targets under negative control by DREAM complex |
  REAC:R-HSA-69656 | 4.95311014697e-09 | 0.833333333333 | TFDP2 E2F5 RB1 E2F1 E2F4 | Cyclin A:Cdk2-associated events at S phase entry |
  REAC:R-HSA-1538133 | 2.10041615528e-08 | 0.666666666667 | TFDP2 E2F5 E2F4 E2F1 | G0 and Early G1 |
  KEGG:04218 | 2.24952036407e-08 | 0.833333333333 | E2F5 E2F2 RB1 E2F1 E2F4 | Cellular senescence |
  REAC:R-HSA-69205 | 2.45022188621e-08 | 0.666666666667 | TFDP2 E2F5 E2F4 E2F1 | G1/S-Specific Transcription |
  GO:0090575 | 4.00189962098e-08 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | RNA polymerase II transcription factor complex |
  REAC:R-HSA-2559585 | 4.30144390958e-08 | 0.666666666667 | TFDP2 E2F2 RB1 E2F1 | Oncogene Induced Senescence |
  REAC:R-HSA-69206 | 4.58062236292e-08 | 0.833333333333 | TFDP2 E2F5 RB1 E2F1 E2F4 | G1/S Transition |
  GO:0044798 | 1.20766429174e-07 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | nuclear transcription factor complex |
  REAC:R-HSA-69242 | 1.26971687219e-07 | 0.833333333333 | TFDP2 E2F5 RB1 E2F1 E2F4 | S Phase |
  WP:WP45 | 1.79003354063e-07 | 0.666666666667 | TFDP2 E2F2 RB1 E2F1 | G1 to S cell cycle control |
  REAC:R-HSA-69278 | 2.75592746566e-07 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | Cell Cycle, Mitotic |
  WP:WP2446 | 6.67174766457e-07 | 0.666666666667 | TFDP2 E2F2 RB1 E2F1 | Retinoblastoma Gene in Cancer |
  REAC:R-HSA-1640170 | 8.1733071499e-07 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | Cell Cycle |
  GO:0005667 | 1.13272677546e-06 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | transcription factor complex |
  REAC:R-HSA-113501 | 1.70064822019e-06 | 0.5 | E2F1 RB1 TFDP2 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
  CORUM:1250 | 8.39001385941e-06 | 0.333333333333 | E2F1 RB1 | RB-E2F1 complex |
  CORUM:5099 | 8.39001385941e-06 | 0.333333333333 | RB1 E2F4 | RB1(hypophosphorylated)-E2F4 complex |
  CORUM:5143 | 8.39001385941e-06 | 0.333333333333 | E2F1 RB1 | RB-E2F1 complex |
  REAC:R-HSA-113510 | 9.14488359438e-06 | 0.5 | E2F1 RB1 TFDP2 | E2F mediated regulation of DNA replication |
  KEGG:05219 | 1.30007694159e-05 | 0.5 | E2F2 RB1 E2F1 | Bladder cancer |
  CORUM:5656 | 2.51655344529e-05 | 0.333333333333 | E2F1 RB1 | CEBPE-E2F1-RB1 complex |
  REAC:R-HSA-2173796 | 2.6656058306e-05 | 0.5 | E2F5 E2F4 TFDP2 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
  CORUM:1488 | 5.0322056017e-05 | 0.333333333333 | E2F1 RB1 | DNMT1-RB1-HDAC1-E2F1 complex |
  REAC:R-HSA-2559583 | 5.92853293102e-05 | 0.666666666667 | TFDP2 E2F2 RB1 E2F1 | Cellular Senescence |
  KEGG:05218 | 6.30413655994e-05 | 0.5 | E2F2 RB1 E2F1 | Melanoma |
  KEGG:05223 | 6.94278084771e-05 | 0.5 | E2F2 RB1 E2F1 | Non-small cell lung cancer |
  REAC:R-HSA-2173793 | 7.30512953501e-05 | 0.5 | E2F5 E2F4 TFDP2 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
  WP:WP4255 | 8.13431193589e-05 | 0.5 | E2F2 RB1 E2F1 | Non-small cell lung cancer |
  KEGG:05214 | 8.34614014946e-05 | 0.5 | E2F2 RB1 E2F1 | Glioma |
  CORUM:2975 | 8.38550741504e-05 | 0.333333333333 | E2F5 E2F4 | SMAD3-E2F4/5-p107-DP1 complex |
  GO:0008134 | 9.11695314609e-05 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | transcription factor binding |
  KEGG:05212 | 9.51406370938e-05 | 0.5 | E2F2 RB1 E2F1 | Pancreatic cancer |
  REAC:R-HSA-6791312 | 0.000102304447254 | 0.5 | E2F1 E2F4 TFDP2 | TP53 Regulates Transcription of Cell Cycle Genes |
  KEGG:05220 | 0.000107857457806 | 0.5 | E2F2 RB1 E2F1 | Chronic myeloid leukemia |
  CORUM:5117 | 0.000125760085813 | 0.333333333333 | E2F5 E2F4 | RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2) |
  CORUM:5118 | 0.000125760085813 | 0.333333333333 | E2F5 E2F4 | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) |
  CORUM:1474 | 0.000125760085813 | 0.333333333333 | E2F5 E2F4 | SMAD3/4-E2F4/5-p107-DP1 complex |
  WP:WP4263 | 0.000136265489266 | 0.5 | E2F2 RB1 E2F1 | Pancreatic adenocarcinoma pathway |
  WP:WP2431 | 0.000168269602893 | 0.5 | E2F5 RB1 E2F1 | Spinal Cord Injury |
  KEGG:01522 | 0.000194995535624 | 0.5 | E2F2 RB1 E2F1 | Endocrine resistance |
  KEGG:05215 | 0.000194995535624 | 0.5 | E2F2 RB1 E2F1 | Prostate cancer |
  WP:WP4658 | 0.000204905145443 | 0.5 | E2F2 RB1 E2F1 | Small cell lung cancer |
  KEGG:05222 | 0.00020837684325 | 0.5 | E2F2 RB1 E2F1 | Small cell lung cancer |
  REAC:R-HSA-111448 | 0.000221597343492 | 0.333333333333 | E2F1 TFDP2 | Activation of NOXA and translocation to mitochondria |
  REAC:R-HSA-170834 | 0.000295535454473 | 0.5 | E2F5 E2F4 TFDP2 | Signaling by TGF-beta Receptor Complex |
  WP:WP236 | 0.000318766546489 | 0.5 | E2F1 RB1 E2F4 | Adipogenesis |
  WP:WP3969 | 0.000507481600471 | 0.333333333333 | E2F1 RB1 | H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity |
  KEGG:05224 | 0.000590221771159 | 0.5 | E2F2 RB1 E2F1 | Breast cancer |
  KEGG:05226 | 0.000603963314278 | 0.5 | E2F2 RB1 E2F1 | Gastric cancer |
  WP:WP4262 | 0.000644066937114 | 0.5 | E2F2 RB1 E2F1 | Breast cancer pathway |
  REAC:R-HSA-9006936 | 0.000667561375412 | 0.5 | E2F5 E2F4 TFDP2 | Signaling by TGF-beta family members |
  KEGG:05160 | 0.000675855226254 | 0.5 | E2F2 RB1 E2F1 | Hepatitis C |
  KEGG:04934 | 0.000753196125616 | 0.5 | E2F2 RB1 E2F1 | Cushing syndrome |
  REAC:R-HSA-139915 | 0.000797179114843 | 0.333333333333 | E2F1 TFDP2 | Activation of PUMA and translocation to mitochondria |
  GO:2000134 | 0.000807281467413 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | negative regulation of G1/S transition of mitotic cell cycle |
  GO:1902807 | 0.00084563217517 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | negative regulation of cell cycle G1/S phase transition |
  GO:0000790 | 0.000873104551204 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | nuclear chromatin |
  GO:0043565 | 0.000937137248598 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | sequence-specific DNA binding |
  KEGG:05161 | 0.00100038089965 | 0.5 | E2F2 RB1 E2F1 | Hepatitis B |
  KEGG:05225 | 0.00107971996751 | 0.5 | E2F2 RB1 E2F1 | Hepatocellular carcinoma |
  KEGG:05167 | 0.00120635789569 | 0.5 | E2F2 RB1 E2F1 | Kaposi sarcoma-associated herpesvirus infection |
  REAC:R-HSA-68689 | 0.0012174763081 | 0.333333333333 | E2F2 E2F1 | CDC6 association with the ORC:origin complex |
  REAC:R-HSA-2262752 | 0.00129372739211 | 0.666666666667 | TFDP2 E2F2 RB1 E2F1 | Cellular responses to stress |
  REAC:R-HSA-212436 | 0.00148146469319 | 0.833333333333 | TFDP2 E2F5 RB1 E2F1 E2F4 | Generic Transcription Pathway |
  KEGG:05169 | 0.0016442646368 | 0.5 | E2F2 RB1 E2F1 | Epstein-Barr virus infection |
  REAC:R-HSA-2559580 | 0.0017268331725 | 0.5 | E2F2 TFDP2 E2F1 | Oxidative Stress Induced Senescence |
  GO:0045892 | 0.00190067692149 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | negative regulation of transcription, DNA-templated |
  GO:1903507 | 0.00192724402011 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | negative regulation of nucleic acid-templated transcription |
  GO:1902679 | 0.00194064316741 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | negative regulation of RNA biosynthetic process |
  KEGG:05166 | 0.00204927990704 | 0.5 | E2F2 RB1 E2F1 | Human T-cell leukemia virus 1 infection |
  KEGG:05163 | 0.00220846662002 | 0.5 | E2F2 RB1 E2F1 | Human cytomegalovirus infection |
  GO:0000785 | 0.00236443918887 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | chromatin |
  GO:0051726 | 0.0023963010185 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | regulation of cell cycle |
  REAC:R-HSA-73857 | 0.00253857262834 | 0.833333333333 | TFDP2 E2F5 RB1 E2F1 E2F4 | RNA Polymerase II Transcription |
  REAC:R-HSA-8953897 | 0.00265671127538 | 0.666666666667 | TFDP2 E2F2 RB1 E2F1 | Cellular responses to external stimuli |
  GO:0003700 | 0.00284417483428 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | DNA-binding transcription factor activity |
  GO:2000045 | 0.0028699930952 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | regulation of G1/S transition of mitotic cell cycle |
  GO:0044454 | 0.00288133296855 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | nuclear chromosome part |
  GO:0051253 | 0.00321383237853 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | negative regulation of RNA metabolic process |
  GO:0000228 | 0.0033810209942 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | nuclear chromosome |
  REAC:R-HSA-6804114 | 0.00338255333894 | 0.333333333333 | E2F4 TFDP2 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
  WP:WP2828 | 0.00349951078021 | 0.333333333333 | E2F1 RB1 | Bladder Cancer |
  GO:0000083 | 0.00366468326223 | 0.5 | E2F1 RB1 TFDP2 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
  WP:WP4320 | 0.00369881973951 | 0.333333333333 | E2F1 RB1 | The effect of progerin on the involved genes in Hutchinson-Gilford Progeria Syndrome |
  GO:1902806 | 0.00410051335196 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | regulation of cell cycle G1/S phase transition |
  REAC:R-HSA-74160 | 0.00435080618405 | 0.833333333333 | TFDP2 E2F5 RB1 E2F1 E2F4 | Gene expression (Transcription) |
  WP:WP2586 | 0.00477752328717 | 0.333333333333 | E2F1 RB1 | Aryl Hydrocarbon Receptor |
  WP:WP1971 | 0.0050096749716 | 0.333333333333 | E2F1 RB1 | Integrated Cancer Pathway |
  GO:0045934 | 0.00502823107793 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | negative regulation of nucleobase-containing compound metabolic process |
  GO:2000113 | 0.00505801329557 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | negative regulation of cellular macromolecule biosynthetic process |
  WP:WP3998 | 0.00524729006009 | 0.333333333333 | E2F1 RB1 | Prader-Willi and Angelman Syndrome |
  GO:0010558 | 0.0055872573376 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | negative regulation of macromolecule biosynthetic process |
  GO:0031327 | 0.00674685170049 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | negative regulation of cellular biosynthetic process |
  GO:0035189 | 0.00676235117068 | 0.333333333333 | E2F1 RB1 | Rb-E2F complex |
  GO:0045893 | 0.0067848978567 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | positive regulation of transcription, DNA-templated |
  GO:1903508 | 0.00690011073089 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | positive regulation of nucleic acid-templated transcription |
  GO:0007093 | 0.006914256367 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | mitotic cell cycle checkpoint |
  GO:1902680 | 0.00693887539792 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | positive regulation of RNA biosynthetic process |
  GO:0009890 | 0.00725557716859 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | negative regulation of biosynthetic process |
  REAC:R-HSA-114452 | 0.00959640616298 | 0.333333333333 | E2F1 TFDP2 | Activation of BH3-only proteins |
  GO:0051254 | 0.0100903948874 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | positive regulation of RNA metabolic process |
  WP:WP2032 | 0.0114940114472 | 0.333333333333 | E2F1 RB1 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
  WP:WP707 | 0.0122135301057 | 0.333333333333 | E2F1 RB1 | DNA Damage Response |
  REAC:R-HSA-8953750 | 0.012367185342 | 0.333333333333 | E2F1 TFDP2 | Transcriptional Regulation by E2F6 |
  WP:WP1530 | 0.0133332445565 | 0.333333333333 | E2F1 RB1 | miRNA Regulation of DNA Damage Response |
  GO:0044427 | 0.0151552637177 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | chromosomal part |
  GO:0140110 | 0.0182161362706 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | transcription regulator activity |
  WP:WP2261 | 0.0182958407223 | 0.333333333333 | E2F1 RB1 | Signaling Pathways in Glioblastoma |
  GO:0003677 | 0.0183905219298 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | DNA binding |
  GO:0010557 | 0.0183905219298 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | positive regulation of macromolecule biosynthetic process |
  GO:0000075 | 0.0184709841663 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | cell cycle checkpoint |
  GO:0007050 | 0.0184709841663 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | cell cycle arrest |
  KEGG:04350 | 0.0185486461013 | 0.333333333333 | E2F5 E2F4 | TGF-beta signaling pathway |
  GO:0005694 | 0.0188325821521 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | chromosome |
  GO:0045935 | 0.0190118679492 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | positive regulation of nucleobase-containing compound metabolic process |
  GO:0000976 | 0.0192711859306 | 0.833333333333 | TFDP2 E2F2 RB1 E2F1 E2F4 | transcription regulatory region sequence-specific DNA binding |
  MIRNA:hsa-miR-98-5p | 0.0201144200719 | 0.666666666667 | E2F5 E2F4 E2F1 E2F2 | hsa-miR-98-5p |
  GO:0071930 | 0.020283420769 | 0.333333333333 | E2F1 RB1 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle |
  GO:0000122 | 0.0207154160577 | 0.833333333333 | E2F5 E2F2 RB1 E2F1 E2F4 | negative regulation of transcription by RNA polymerase II |
  WP:WP615 | 0.021546686463 | 0.333333333333 | E2F1 RB1 | Senescence and Autophagy in Cancer |
  GO:0007049 | 0.0218766736595 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | cell cycle |
  GO:1901991 | 0.0222594167129 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | negative regulation of mitotic cell cycle phase transition |
  GO:0000082 | 0.0236425639653 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | G1/S transition of mitotic cell cycle |
  GO:0031328 | 0.0236537874457 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | positive regulation of cellular biosynthetic process |
  GO:0009891 | 0.0255496072011 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | positive regulation of biosynthetic process |
  KEGG:05200 | 0.0260948095216 | 0.5 | E2F2 RB1 E2F1 | Pathways in cancer |
  REAC:R-HSA-109606 | 0.0269276420577 | 0.333333333333 | E2F1 TFDP2 | Intrinsic Pathway for Apoptosis |
  GO:1990837 | 0.028320562987 | 0.833333333333 | TFDP2 E2F2 RB1 E2F1 E2F4 | sequence-specific double-stranded DNA binding |
  GO:1901988 | 0.0287203705471 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | negative regulation of cell cycle phase transition |
  GO:0090068 | 0.0292695060103 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | positive regulation of cell cycle process |
  GO:0044843 | 0.0298264479231 | 0.666666666667 | TFDP2 E2F1 RB1 E2F4 | cell cycle G1/S phase transition |
  GO:0010628 | 0.0317362653276 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | positive regulation of gene expression |
  GO:0006357 | 0.0329980810507 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | regulation of transcription by RNA polymerase II |
  GO:0010629 | 0.0362595770553 | 1.0 | E2F1 E2F4 E2F5 TFDP2 RB1 E2F2 | negative regulation of gene expression |
  MIRNA:hsa-miR-519d-3p | 0.0364157760598 | 0.666666666667 | E2F5 RB1 E2F1 E2F2 | hsa-miR-519d-3p |
  MIRNA:hsa-miR-1178-5p | 0.0371299472089 | 0.333333333333 | RB1 E2F4 | hsa-miR-1178-5p |
  MIRNA:hsa-miR-20b-5p | 0.0385495620595 | 0.666666666667 | E2F5 RB1 E2F1 E2F2 | hsa-miR-20b-5p |
  REAC:R-HSA-3700989 | 0.0393483138606 | 0.5 | E2F1 E2F4 TFDP2 | Transcriptional Regulation by TP53 |
  MIRNA:hsa-miR-23b-3p | 0.0404895558515 | 0.5 | E2F1 RB1 E2F4 | hsa-miR-23b-3p |
  WP:WP366 | 0.0416969783243 | 0.333333333333 | E2F5 E2F4 | TGF-beta Signaling Pathway |
  GO:0006977 | 0.0447070305646 | 0.5 | E2F1 E2F4 TFDP2 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
  GO:0044212 | 0.0447640451545 | 0.833333333333 | TFDP2 E2F2 RB1 E2F1 E2F4 | transcription regulatory region DNA binding |
  GO:0001067 | 0.0447640451545 | 0.833333333333 | TFDP2 E2F2 RB1 E2F1 E2F4 | regulatory region nucleic acid binding |
  GO:0072431 | 0.0472791215337 | 0.5 | E2F1 E2F4 TFDP2 | signal transduction involved in mitotic G1 DNA damage checkpoint |
  GO:1902400 | 0.0472791215337 | 0.5 | E2F1 E2F4 TFDP2 | intracellular signal transduction involved in G1 DNA damage checkpoint |
  REAC:R-HSA-68867 | 0.0499130144295 | 0.333333333333 | E2F2 E2F1 | Assembly of the pre-replicative complex |
  GO:0072413 | 0.0499477329172 | 0.5 | E2F1 E2F4 TFDP2 | signal transduction involved in mitotic cell cycle checkpoint |
  GO:1902403 | 0.0499477329172 | 0.5 | E2F1 E2F4 TFDP2 | signal transduction involved in mitotic DNA integrity checkpoint |
  GO:1902402 | 0.0499477329172 | 0.5 | E2F1 E2F4 TFDP2 | signal transduction involved in mitotic DNA damage checkpoint |
  CORUM:6588 | 0.0499726005494 | 0.166666666667 | E2F1 | E2F-1-DP-1 complex |
  CORUM:5663 | 0.0499726005494 | 0.166666666667 | RB1 | TRIM27-RB1 complex |
  CORUM:5160 | 0.0499726005494 | 0.166666666667 | E2F4 | E2F4-p130 complex |
  CORUM:5146 | 0.0499726005494 | 0.166666666667 | RB1 | RB1-TFAP2A complex |
  CORUM:3853 | 0.0499726005494 | 0.166666666667 | RB1 | Rb-HDAC1 complex |
Edges
Protein 1 | Protein 2 | Score | Precision | Evidence |
---|---|---|---|---|
 TFDP2 |  E2F2 | 0.999 | 0.946           | bioplex (TFDP2)     bioplex_WMM     |
 E2F1 |  TFDP2 | 0.996 | 0.926           | bioplex (TFDP2)     bioplex_WMM     |
 TFDP2 |  E2F5 | 0.967 | 0.879           | bioplex (TFDP2)     bioplex_WMM     boldt_WMM     |
 TFDP2 |  E2F4 | 0.753 | 0.747           | bioplex (TFDP2)     bioplex_WMM     boldt_WMM     |
 TFDP2 |  RB1 | 0.034 | 0.262           | bioplex (TFDP2)     bioplex_WMM     |
 E2F5 |  E2F4 | 0.012 | 0.145           | bioplex_WMM     boldt (E2F4)     boldt_WMM     |
 E2F1 |  E2F2 | 0.01 | 0.105           | bioplex_WMM     WMM_only     |
 E2F2 |  E2F5 | 0.009 | 0.102           | bioplex_WMM     WMM_only     |
 E2F1 |  E2F5 | 0.009 | 0.102           | bioplex_WMM     WMM_only     |
 E2F2 |  E2F4 | 0.009 | 0.096           | bioplex_WMM     WMM_only     |
 E2F1 |  E2F4 | 0.009 | 0.096           | bioplex_WMM     WMM_only     |
 E2F1 |  RB1 | 0.008 | 0.019           | bioplex_WMM     WMM_only     |
 E2F2 |  RB1 | 0.008 | 0.019           | bioplex_WMM     WMM_only     |
 E2F4 |  RB1 | 0.007 | 0.013           | bioplex_WMM     WMM_only     |
 E2F5 |  RB1 | 0.007 | 0.01           | bioplex_WMM     WMM_only     |
Images
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Complex HuMAP2_02343 has an average edge precision of 0.298 which is ranked 4631 out of all 6965 complexes.
Related Complexes
Genename | Complexes |
---|---|
E2F1 | HuMAP2_00571 HuMAP2_01975 HuMAP2_02343 HuMAP2_06111 |
TFDP2 | HuMAP2_00571 HuMAP2_01975 HuMAP2_02343 HuMAP2_06111 |
RB1 | HuMAP2_02343 |
E2F4 | HuMAP2_01975 HuMAP2_02343 HuMAP2_04984 HuMAP2_06111 |
E2F5 | HuMAP2_00593 HuMAP2_02343 HuMAP2_04040 HuMAP2_06111 |
E2F2 | HuMAP2_00571 HuMAP2_01975 HuMAP2_02343 HuMAP2_06111 |