hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02351
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SF3B6 | Splicing factor 3B subunit 6 (Pre-mRNA branch site protein p14) (SF3b 14 kDa subunit) (SF3B14a) (Spliceosome-associated protein, 14-kDa) (Splicing factor 3b, subunit 6, 14kDa) | UniProt NCBI |
| SF3B3 | Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130) | UniProt NCBI |
| SF3B4 | Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49) | UniProt NCBI |
| SF3B5 | Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit) | UniProt NCBI |
| SF3B2 | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145) | UniProt NCBI |
| SF3B1 | Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) | UniProt NCBI |
| PHF5A | PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b) | UniProt NCBI |
| DDX42 | ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1737 | 7.72311614252e-28 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | SF3b complex |
| CORUM:2755 | 3.86417390398e-17 | 0.875 | SF3B1 SF3B5 SF3B3 SF3B6 SF3B2 SF3B4 PHF5A | 17S U2 snRNP |
| KEGG:03040 | 1.30261647488e-15 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | Spliceosome |
| REAC:R-HSA-72165 | 5.87530204088e-15 | 0.875 | SF3B1 SF3B5 SF3B3 SF3B2 SF3B6 DDX42 SF3B4 | mRNA Splicing - Minor Pathway |
| GO:0005689 | 5.9626307868e-15 | 0.875 | SF3B1 SF3B5 SF3B3 SF3B6 SF3B2 SF3B4 PHF5A | U12-type spliceosomal complex |
| CORUM:430 | 1.14957593036e-14 | 0.75 | SF3B1 SF3B5 SF3B3 SF3B2 SF3B6 SF3B4 | 18S U11/U12 snRNP |
| REAC:R-HSA-72163 | 6.30246704616e-14 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 9.02143810791e-14 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | mRNA Splicing |
| REAC:R-HSA-72203 | 6.04901220136e-13 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | Processing of Capped Intron-Containing Pre-mRNA |
| WP:WP411 | 4.32845222158e-10 | 0.75 | SF3B1 SF3B5 SF3B3 SF3B2 SF3B4 PHF5A | mRNA Processing |
| GO:0071005 | 1.46140232881e-09 | 0.75 | SF3B1 SF3B5 SF3B3 SF3B2 SF3B4 PHF5A | U2-type precatalytic spliceosome |
| GO:0071011 | 1.6560647881e-09 | 0.75 | SF3B1 SF3B5 SF3B3 SF3B2 SF3B4 PHF5A | precatalytic spliceosome |
| GO:0000377 | 1.69684163608e-09 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 1.69684163608e-09 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | mRNA splicing, via spliceosome |
| GO:0000375 | 1.83343792345e-09 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | RNA splicing, via transesterification reactions |
| REAC:R-HSA-8953854 | 2.29458867922e-09 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | Metabolism of RNA |
| GO:0005681 | 5.99791169406e-09 | 0.875 | SF3B1 SF3B5 SF3B3 SF3B6 SF3B2 SF3B4 PHF5A | spliceosomal complex |
| GO:0008380 | 6.73317232465e-09 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | RNA splicing |
| GO:0006397 | 1.21342588457e-08 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | mRNA processing |
| GO:0005684 | 6.10113623344e-08 | 0.75 | SF3B1 SF3B5 SF3B3 SF3B2 SF3B4 PHF5A | U2-type spliceosomal complex |
| CORUM:351 | 1.73129182849e-07 | 0.625 | SF3B1 SF3B3 SF3B4 SF3B2 SF3B6 | Spliceosome |
| GO:0016071 | 1.32830215932e-06 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | mRNA metabolic process |
| GO:0006396 | 2.51669931039e-06 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | RNA processing |
| GO:0005686 | 5.20982418286e-06 | 0.5 | SF3B1 SF3B5 PHF5A SF3B2 | U2 snRNP |
| CORUM:1183 | 1.7094730322e-05 | 0.375 | SF3B1 SF3B4 SF3B2 | CDC5L complex |
| GO:1990904 | 0.000314440449716 | 0.875 | SF3B1 SF3B5 SF3B3 SF3B6 SF3B2 SF3B4 PHF5A | ribonucleoprotein complex |
| CORUM:1181 | 0.000351537576296 | 0.375 | SF3B3 SF3B2 SF3B1 | C complex spliceosome |
| CORUM:0000000 | 0.000356401437906 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | CORUM root |
| GO:0097525 | 0.000666904519799 | 0.5 | SF3B1 SF3B5 PHF5A SF3B2 | spliceosomal snRNP complex |
| GO:0030532 | 0.0010043755339 | 0.5 | SF3B1 SF3B5 PHF5A SF3B2 | small nuclear ribonucleoprotein complex |
| GO:0120114 | 0.00193552303911 | 0.5 | SF3B1 SF3B5 PHF5A SF3B2 | Sm-like protein family complex |
| GO:1990935 | 0.0126230555186 | 0.25 | SF3B5 SF3B4 | splicing factor binding |
| GO:0003723 | 0.0270720656443 | 0.875 | PHF5A SF3B5 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | RNA binding |
| HPA:043010_13 | 0.0384534319764 | 0.375 | SF3B3 PHF5A SF3B2 | skin 1; Langerhans[Supported,High] |
| KEGG:00000 | 0.045111549543 | 1.0 | PHF5A SF3B5 SF3B3 SF3B6 SF3B2 DDX42 SF3B4 SF3B1 | KEGG root term |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SF3B1 | SF3B2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SF3B3 | SF3B5 | 1.0 | 0.949 | bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| SF3B3 | SF3B2 | 1.0 | 0.949 | bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SF3B1 | SF3B3 | 1.0 | 0.949 | bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SF3B1 | SF3B5 | 1.0 | 0.949 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SF3B1 | SF3B4 | 1.0 | 0.949 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| SF3B5 | SF3B6 | 1.0 | 0.949 | bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| SF3B2 | SF3B4 | 1.0 | 0.949 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| SF3B1 | SF3B6 | 0.999 | 0.949 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SF3B2 | PHF5A | 0.999 | 0.947 | hein_WMM bioplex_WMM youn_WMM fraction boldt_WMM |
| SF3B2 | SF3B5 | 0.998 | 0.938 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SF3B1 | PHF5A | 0.997 | 0.93 | hein_WMM bioplex_WMM youn_WMM fraction boldt_WMM |
| SF3B2 | SF3B6 | 0.997 | 0.929 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SF3B3 | SF3B6 | 0.996 | 0.927 | bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PHF5A | SF3B4 | 0.988 | 0.901 | bioplex_WMM youn_WMM fraction boldt_WMM |
| SF3B5 | SF3B4 | 0.988 | 0.901 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SF3B4 | SF3B6 | 0.988 | 0.901 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM |
| SF3B5 | PHF5A | 0.988 | 0.901 | bioplex_WMM fraction treiber_WMM |
| SF3B3 | SF3B4 | 0.988 | 0.901 | bioplex_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| SF3B3 | PHF5A | 0.988 | 0.901 | bioplex_WMM fraction boldt_WMM treiber_WMM |
| DDX42 | SF3B2 | 0.988 | 0.901 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| DDX42 | SF3B5 | 0.879 | 0.813 | bioplex_WMM youn_WMM gupta_WMM fraction |
| PHF5A | SF3B6 | 0.56 | 0.65 | bioplex_WMM youn_WMM fraction boldt_WMM treiber_WMM |
| DDX42 | SF3B3 | 0.526 | 0.634 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| DDX42 | PHF5A | 0.103 | 0.366 | bioplex_WMM youn_WMM fraction |
| DDX42 | SF3B4 | 0.007 | 0.004 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| DDX42 | SF3B6 | 0.006 | 0.003 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| DDX42 | SF3B1 | 0.005 | 0.011 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_02351 has an average edge precision of 0.786 which is ranked 982 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SF3B6 | HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |
| SF3B3 | HuMAP2_02124 HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |
| SF3B4 | HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |
| SF3B5 | HuMAP2_02124 HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |
| SF3B2 | HuMAP2_02124 HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |
| SF3B1 | HuMAP2_02124 HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |
| PHF5A | HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |
| DDX42 | HuMAP2_00646 HuMAP2_02351 HuMAP2_02806 HuMAP2_05865 |