hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02354
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUP214 | Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) | UniProt NCBI |
| NUP88 | Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup88) | UniProt NCBI |
| NUP62 | Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-168333 | 1.47287948045e-06 | 1.0 | NUP214 NUP88 NUP62 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168271 | 1.47287948045e-06 | 1.0 | NUP214 NUP88 NUP62 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168274 | 1.47287948045e-06 | 1.0 | NUP214 NUP88 NUP62 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-5619107 | 1.47287948045e-06 | 1.0 | NUP214 NUP88 NUP62 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-170822 | 1.47287948045e-06 | 1.0 | NUP214 NUP88 NUP62 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-180746 | 1.82536345868e-06 | 1.0 | NUP214 NUP88 NUP62 | Nuclear import of Rev protein |
| REAC:R-HSA-180910 | 1.82536345868e-06 | 1.0 | NUP214 NUP88 NUP62 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-159227 | 1.82536345868e-06 | 1.0 | NUP214 NUP88 NUP62 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-165054 | 2.02093811497e-06 | 1.0 | NUP214 NUP88 NUP62 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-159230 | 2.02093811497e-06 | 1.0 | NUP214 NUP88 NUP62 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-4085377 | 2.02093811497e-06 | 1.0 | NUP214 NUP88 NUP62 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-3301854 | 2.23000067859e-06 | 1.0 | NUP214 NUP88 NUP62 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-176033 | 2.45300074645e-06 | 1.0 | NUP214 NUP88 NUP62 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 2.45300074645e-06 | 1.0 | NUP214 NUP88 NUP62 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-3232142 | 2.69038791546e-06 | 1.0 | NUP214 NUP88 NUP62 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 3.49336799851e-06 | 1.0 | NUP214 NUP88 NUP62 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 3.49336799851e-06 | 1.0 | NUP214 NUP88 NUP62 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 3.79279954124e-06 | 1.0 | NUP214 NUP88 NUP62 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168253 | 3.79279954124e-06 | 1.0 | NUP214 NUP88 NUP62 | Host Interactions with Influenza Factors |
| REAC:R-HSA-168325 | 4.44201748073e-06 | 1.0 | NUP214 NUP88 NUP62 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4570464 | 5.16137253834e-06 | 1.0 | NUP214 NUP88 NUP62 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4615885 | 5.16137253834e-06 | 1.0 | NUP214 NUP88 NUP62 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-2980766 | 6.37978016717e-06 | 1.0 | NUP214 NUP88 NUP62 | Nuclear Envelope Breakdown |
| REAC:R-HSA-194441 | 8.81209945571e-06 | 1.0 | NUP214 NUP88 NUP62 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 8.81209945571e-06 | 1.0 | NUP214 NUP88 NUP62 | snRNP Assembly |
| REAC:R-HSA-6784531 | 1.11518017806e-05 | 1.0 | NUP214 NUP88 NUP62 | tRNA processing in the nucleus |
| KEGG:03013 | 1.76006400333e-05 | 1.0 | NUP214 NUP88 NUP62 | RNA transport |
| REAC:R-HSA-3371453 | 1.96383930727e-05 | 1.0 | NUP214 NUP88 NUP62 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-4551638 | 1.96383930727e-05 | 1.0 | NUP214 NUP88 NUP62 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-70171 | 2.05735546476e-05 | 1.0 | NUP214 NUP88 NUP62 | Glycolysis |
| REAC:R-HSA-1169408 | 2.15379400217e-05 | 1.0 | NUP214 NUP88 NUP62 | ISG15 antiviral mechanism |
| REAC:R-HSA-159236 | 2.2531998792e-05 | 1.0 | NUP214 NUP88 NUP62 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 2.56967114485e-05 | 1.0 | NUP214 NUP88 NUP62 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 2.9144670159e-05 | 1.0 | NUP214 NUP88 NUP62 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-72202 | 3.28880140401e-05 | 1.0 | NUP214 NUP88 NUP62 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-5619102 | 3.69388822082e-05 | 1.0 | NUP214 NUP88 NUP62 | SLC transporter disorders |
| REAC:R-HSA-70326 | 3.98163024387e-05 | 1.0 | NUP214 NUP88 NUP62 | Glucose metabolism |
| REAC:R-HSA-3371556 | 4.44066869e-05 | 1.0 | NUP214 NUP88 NUP62 | Cellular response to heat stress |
| REAC:R-HSA-72306 | 7.71957896197e-05 | 1.0 | NUP214 NUP88 NUP62 | tRNA processing |
| REAC:R-HSA-5578749 | 7.71957896197e-05 | 1.0 | NUP214 NUP88 NUP62 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-162909 | 0.000132738992005 | 1.0 | NUP214 NUP88 NUP62 | Host Interactions of HIV factors |
| REAC:R-HSA-168273 | 0.000160847790881 | 1.0 | NUP214 NUP88 NUP62 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-211000 | 0.000168445978677 | 1.0 | NUP214 NUP88 NUP62 | Gene Silencing by RNA |
| REAC:R-HSA-68875 | 0.000168445978677 | 1.0 | NUP214 NUP88 NUP62 | Mitotic Prophase |
| REAC:R-HSA-162599 | 0.00017233319357 | 1.0 | NUP214 NUP88 NUP62 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168255 | 0.000192668461855 | 1.0 | NUP214 NUP88 NUP62 | Influenza Life Cycle |
| REAC:R-HSA-162587 | 0.000228431198544 | 1.0 | NUP214 NUP88 NUP62 | HIV Life Cycle |
| REAC:R-HSA-168254 | 0.000238014806299 | 1.0 | NUP214 NUP88 NUP62 | Influenza Infection |
| REAC:R-HSA-5619115 | 0.000279028834908 | 1.0 | NUP214 NUP88 NUP62 | Disorders of transmembrane transporters |
| REAC:R-HSA-3108232 | 0.000336595223393 | 1.0 | NUP214 NUP88 NUP62 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.000374667089817 | 1.0 | NUP214 NUP88 NUP62 | SUMOylation |
| REAC:R-HSA-913531 | 0.000387967964833 | 1.0 | NUP214 NUP88 NUP62 | Interferon Signaling |
| GO:0071431 | 0.000495506150782 | 1.0 | NUP214 NUP88 NUP62 | tRNA-containing ribonucleoprotein complex export from nucleus |
| GO:0006409 | 0.000495506150782 | 1.0 | NUP214 NUP88 NUP62 | tRNA export from nucleus |
| GO:0051031 | 0.000594407580071 | 1.0 | NUP214 NUP88 NUP62 | tRNA transport |
| GO:0097064 | 0.0007056603357 | 1.0 | NUP214 NUP88 NUP62 | ncRNA export from nucleus |
| REAC:R-HSA-162906 | 0.000819826928908 | 1.0 | NUP214 NUP88 NUP62 | HIV Infection |
| REAC:R-HSA-72203 | 0.000960089475622 | 1.0 | NUP214 NUP88 NUP62 | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-71387 | 0.00133225455863 | 1.0 | NUP214 NUP88 NUP62 | Metabolism of carbohydrates |
| GO:0075733 | 0.00225266395968 | 1.0 | NUP214 NUP88 NUP62 | intracellular transport of virus |
| GO:0046794 | 0.00265735153444 | 1.0 | NUP214 NUP88 NUP62 | transport of virus |
| REAC:R-HSA-5663205 | 0.00340936351327 | 1.0 | NUP214 NUP88 NUP62 | Infectious disease |
| GO:0006110 | 0.00378386515143 | 1.0 | NUP214 NUP88 NUP62 | regulation of glycolytic process |
| REAC:R-HSA-68886 | 0.00398320383305 | 1.0 | NUP214 NUP88 NUP62 | M Phase |
| GO:0016925 | 0.00475834847216 | 1.0 | NUP214 NUP88 NUP62 | protein sumoylation |
| GO:0043470 | 0.00475834847216 | 1.0 | NUP214 NUP88 NUP62 | regulation of carbohydrate catabolic process |
| GO:1902579 | 0.00475834847216 | 1.0 | NUP214 NUP88 NUP62 | multi-organism localization |
| GO:0044766 | 0.00475834847216 | 1.0 | NUP214 NUP88 NUP62 | multi-organism transport |
| REAC:R-HSA-2262752 | 0.00501472976187 | 1.0 | NUP214 NUP88 NUP62 | Cellular responses to stress |
| GO:1900034 | 0.00638454589443 | 1.0 | NUP214 NUP88 NUP62 | regulation of cellular response to heat |
| GO:0005643 | 0.00664337883609 | 1.0 | NUP214 NUP88 NUP62 | nuclear pore |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | NUP214 NUP88 NUP62 | Cellular responses to external stimuli |
| GO:1900542 | 0.00929437307021 | 1.0 | NUP214 NUP88 NUP62 | regulation of purine nucleotide metabolic process |
| GO:0006140 | 0.00996606725847 | 1.0 | NUP214 NUP88 NUP62 | regulation of nucleotide metabolic process |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | NUP214 NUP88 NUP62 | Cell Cycle, Mitotic |
| GO:1903578 | 0.011404996777 | 1.0 | NUP214 NUP88 NUP62 | regulation of ATP metabolic process |
| GO:0006096 | 0.0117851633362 | 1.0 | NUP214 NUP88 NUP62 | glycolytic process |
| GO:0006757 | 0.0121736852044 | 1.0 | NUP214 NUP88 NUP62 | ATP generation from ADP |
| GO:0046031 | 0.0129761581422 | 1.0 | NUP214 NUP88 NUP62 | ADP metabolic process |
| GO:0009135 | 0.0138131421388 | 1.0 | NUP214 NUP88 NUP62 | purine nucleoside diphosphate metabolic process |
| GO:0009179 | 0.0138131421388 | 1.0 | NUP214 NUP88 NUP62 | purine ribonucleoside diphosphate metabolic process |
| GO:0006606 | 0.0142448028307 | 1.0 | NUP214 NUP88 NUP62 | protein import into nucleus |
| GO:0009185 | 0.0146853637429 | 1.0 | NUP214 NUP88 NUP62 | ribonucleoside diphosphate metabolic process |
| GO:0006165 | 0.0151349156943 | 1.0 | NUP214 NUP88 NUP62 | nucleoside diphosphate phosphorylation |
| GO:0046939 | 0.0155935495032 | 1.0 | NUP214 NUP88 NUP62 | nucleotide phosphorylation |
| GO:0034605 | 0.0160613559883 | 1.0 | NUP214 NUP88 NUP62 | cellular response to heat |
| GO:0060964 | 0.0170248502613 | 1.0 | NUP214 NUP88 NUP62 | regulation of gene silencing by miRNA |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | NUP214 NUP88 NUP62 | Cell Cycle |
| GO:0071427 | 0.0180261250619 | 1.0 | NUP214 NUP88 NUP62 | mRNA-containing ribonucleoprotein complex export from nucleus |
| GO:0060147 | 0.0180261250619 | 1.0 | NUP214 NUP88 NUP62 | regulation of posttranscriptional gene silencing |
| GO:0006406 | 0.0180261250619 | 1.0 | NUP214 NUP88 NUP62 | mRNA export from nucleus |
| GO:0009132 | 0.0180261250619 | 1.0 | NUP214 NUP88 NUP62 | nucleoside diphosphate metabolic process |
| GO:0060966 | 0.0180261250619 | 1.0 | NUP214 NUP88 NUP62 | regulation of gene silencing by RNA |
| REAC:R-HSA-8953854 | 0.0206735000409 | 1.0 | NUP214 NUP88 NUP62 | Metabolism of RNA |
| GO:0051028 | 0.0206993698472 | 1.0 | NUP214 NUP88 NUP62 | mRNA transport |
| GO:0009408 | 0.0236246361809 | 1.0 | NUP214 NUP88 NUP62 | response to heat |
| REAC:R-HSA-1280215 | 0.0245091821355 | 1.0 | NUP214 NUP88 NUP62 | Cytokine Signaling in Immune system |
| GO:0051170 | 0.0248678516681 | 1.0 | NUP214 NUP88 NUP62 | import into nucleus |
| GO:0043467 | 0.0248678516681 | 1.0 | NUP214 NUP88 NUP62 | regulation of generation of precursor metabolites and energy |
| GO:0071426 | 0.0268132763851 | 1.0 | NUP214 NUP88 NUP62 | ribonucleoprotein complex export from nucleus |
| GO:0071166 | 0.0274836082947 | 1.0 | NUP214 NUP88 NUP62 | ribonucleoprotein complex localization |
| GO:0006090 | 0.0288576025313 | 1.0 | NUP214 NUP88 NUP62 | pyruvate metabolic process |
| GO:0006405 | 0.033252767518 | 1.0 | NUP214 NUP88 NUP62 | RNA export from nucleus |
| GO:0006109 | 0.0364177948924 | 1.0 | NUP214 NUP88 NUP62 | regulation of carbohydrate metabolic process |
| GO:0035195 | 0.0397775372938 | 1.0 | NUP214 NUP88 NUP62 | gene silencing by miRNA |
| GO:0009266 | 0.0406485782564 | 1.0 | NUP214 NUP88 NUP62 | response to temperature stimulus |
| GO:0017038 | 0.043337807111 | 1.0 | NUP214 NUP88 NUP62 | protein import |
| GO:0060968 | 0.043337807111 | 1.0 | NUP214 NUP88 NUP62 | regulation of gene silencing |
| GO:0035194 | 0.0480789908723 | 1.0 | NUP214 NUP88 NUP62 | posttranscriptional gene silencing by RNA |
| GO:0016441 | 0.0490669153423 | 1.0 | NUP214 NUP88 NUP62 | posttranscriptional gene silencing |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NUP214 | NUP88 | 1.0 | 0.949 | hein_WMM bioplex (NUP88) bioplex_WMM Guru youn_WMM hein (NUP214) Malo gupta_WMM fraction boldt_WMM |
| NUP214 | NUP62 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (NUP214) Malo gupta_WMM fraction boldt_WMM |
| NUP88 | NUP62 | 0.995 | 0.924 | hein_WMM bioplex (NUP88) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_02354 has an average edge precision of 0.941 which is ranked 394 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NUP214 | HuMAP2_01628 HuMAP2_02354 HuMAP2_05637 HuMAP2_05690 |
| NUP88 | HuMAP2_01628 HuMAP2_02354 HuMAP2_05637 HuMAP2_05690 HuMAP2_06331 |
| NUP62 | HuMAP2_01628 HuMAP2_02128 HuMAP2_02354 HuMAP2_05690 HuMAP2_06331 |