hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02376
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PPP1R13B | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) | UniProt NCBI |
| RASSF7 | Ras association domain-containing protein 7 (HRAS1-related cluster protein 1) | UniProt NCBI |
| TP53BP2 | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | UniProt NCBI |
| FRMD6 | FERM domain-containing protein 6 (Willin) | UniProt NCBI |
| RASSF8 | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-139915 | 0.000485460775426 | 0.4 | PPP1R13B TP53BP2 | Activation of PUMA and translocation to mitochondria |
| REAC:R-HSA-6803211 | 0.000606744453221 | 0.4 | PPP1R13B TP53BP2 | TP53 Regulates Transcription of Death Receptors and Ligands |
| REAC:R-HSA-6804759 | 0.00105126658749 | 0.4 | PPP1R13B TP53BP2 | Regulation of TP53 Activity through Association with Co-factors |
| REAC:R-HSA-6803205 | 0.00105126658749 | 0.4 | PPP1R13B TP53BP2 | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| REAC:R-HSA-6803204 | 0.00255837003151 | 0.4 | PPP1R13B TP53BP2 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| REAC:R-HSA-114452 | 0.00584945327803 | 0.4 | PPP1R13B TP53BP2 | Activation of BH3-only proteins |
| REAC:R-HSA-5633008 | 0.0104745816743 | 0.4 | PPP1R13B TP53BP2 | TP53 Regulates Transcription of Cell Death Genes |
| REAC:R-HSA-109606 | 0.0164283536306 | 0.4 | PPP1R13B TP53BP2 | Intrinsic Pathway for Apoptosis |
| KEGG:04390 | 0.0421802717446 | 0.4 | FRMD6 TP53BP2 | Hippo signaling pathway |
| CORUM:644 | 0.0499494897235 | 0.2 | PPP1R13B | ASPP1-SAM68 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TP53BP2 | RASSF8 | 1.0 | 0.949 | hein_WMM bioplex (RASSF8) bioplex_WMM boldt youn_WMM hein (RASSF8) gupta_WMM boldt_WMM |
| RASSF8 | PPP1R13B | 0.983 | 0.899 | bioplex (RASSF8) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RASSF7 | TP53BP2 | 0.978 | 0.894 | hein_WMM bioplex (RASSF7) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RASSF7 | PPP1R13B | 0.475 | 0.609 | bioplex (RASSF7) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| FRMD6 | RASSF8 | 0.181 | 0.436 | bioplex (FRMD6,RASSF8) bioplex_WMM boldt_WMM |
| FRMD6 | TP53BP2 | 0.047 | 0.29 | bioplex (FRMD6) bioplex_WMM boldt_WMM |
| TP53BP2 | PPP1R13B | 0.02 | 0.186 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RASSF7 | RASSF8 | 0.014 | 0.138 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| FRMD6 | PPP1R13B | 0.008 | 0.024 | bioplex_WMM WMM_only |
| FRMD6 | RASSF7 | 0.0 | 0.009 | bioplex (FRMD6) bioplex_WMM |
Images
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Complex HuMAP2_02376 has an average edge precision of 0.443 which is ranked 2918 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PPP1R13B | HuMAP2_00604 HuMAP2_02149 HuMAP2_02376 HuMAP2_05899 |
| RASSF7 | HuMAP2_00604 HuMAP2_02376 HuMAP2_04686 HuMAP2_05899 |
| TP53BP2 | HuMAP2_00604 HuMAP2_01276 HuMAP2_02376 HuMAP2_02503 HuMAP2_04109 HuMAP2_04686 |
| FRMD6 | HuMAP2_00008 HuMAP2_01276 HuMAP2_02376 HuMAP2_02503 HuMAP2_04109 HuMAP2_04491 |
| RASSF8 | HuMAP2_00604 HuMAP2_01053 HuMAP2_01276 HuMAP2_02149 HuMAP2_02376 HuMAP2_02503 HuMAP2_04109 |