hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02380
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAGEA9 | Melanoma-associated antigen 9 (Cancer/testis antigen 1.9) (CT1.9) (MAGE-9 antigen) | UniProt NCBI |
| NCOA2 | Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) | UniProt NCBI |
| KAT2A | Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97) | UniProt NCBI |
| ERI1 | 3'-5' exoribonuclease 1 (EC 3.1.-.-) (3'-5' exonuclease ERI1) (Eri-1 homolog) (Histone mRNA 3'-end-specific exoribonuclease) (Histone mRNA 3'-exonuclease 1) (Protein 3'hExo) (HEXO) | UniProt NCBI |
| CRTC3 | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) | UniProt NCBI |
| FAM216A | Protein FAM216A | UniProt NCBI |
| MAGEA10 | Melanoma-associated antigen 10 (Cancer/testis antigen 1.10) (CT1.10) (MAGE-10 antigen) | UniProt NCBI |
| KAT2B | Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57) | UniProt NCBI |
| FOXJ2 | Forkhead box protein J2 (Fork head homologous X) | UniProt NCBI |
| QSER1 | Glutamine and serine-rich protein 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04919 | 0.00176832627971 | 0.333333333333 | KAT2A KAT2B NCOA2 | Thyroid hormone signaling pathway |
| REAC:R-HSA-8941856 | 0.00502611584178 | 0.222222222222 | KAT2A KAT2B | RUNX3 regulates NOTCH signaling |
| REAC:R-HSA-210744 | 0.00586196406613 | 0.222222222222 | KAT2A KAT2B | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| KEGG:05166 | 0.0092388494149 | 0.333333333333 | KAT2A KAT2B CRTC3 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-9013695 | 0.010998087958 | 0.222222222222 | KAT2A KAT2B | NOTCH4 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-3214847 | 0.0136137218332 | 0.333333333333 | KAT2A KAT2B NCOA2 | HATs acetylate histones |
| WP:WP268 | 0.0142365065226 | 0.222222222222 | KAT2A KAT2B | Notch Signaling |
| REAC:R-HSA-9013508 | 0.0162516337822 | 0.222222222222 | KAT2A KAT2B | NOTCH3 Intracellular Domain Regulates Transcription |
| KEGG:04330 | 0.0177057130567 | 0.222222222222 | KAT2A KAT2B | Notch signaling pathway |
| REAC:R-HSA-350054 | 0.0225184776205 | 0.222222222222 | KAT2A KAT2B | Notch-HLH transcription pathway |
| REAC:R-HSA-186712 | 0.0260306873727 | 0.222222222222 | KAT2A KAT2B | Regulation of beta-cell development |
| CORUM:1338 | 0.0499262710315 | 0.111111111111 | KAT2B | FOXO3-PCAF complex, oxidative stress stimulated |
| CORUM:2641 | 0.0499262710315 | 0.111111111111 | KAT2B | CREBBP-KAT2B-MYOD1 complex |
| CORUM:6936 | 0.0499262710315 | 0.111111111111 | KAT2A | KAT2A-TRRAP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAGEA10 | FOXJ2 | 1.0 | 0.949 | hein_WMM bioplex (MAGEA10) bioplex_WMM hein (MAGEA10) |
| MAGEA10 | NCOA2 | 1.0 | 0.949 | hein_WMM bioplex (MAGEA10) bioplex_WMM hein (MAGEA10) |
| MAGEA10 | KAT2A | 1.0 | 0.949 | hein_WMM bioplex (MAGEA10) bioplex_WMM hein (MAGEA10) |
| MAGEA10 | FAM216A | 1.0 | 0.949 | hein_WMM bioplex (MAGEA10) bioplex_WMM hein (MAGEA10) |
| MAGEA9 | MAGEA10 | 0.809 | 0.769 | bioplex (MAGEA10) bioplex_WMM |
| MAGEA10 | ERI1 | 0.44 | 0.584 | bioplex (MAGEA10) bioplex_WMM |
| MAGEA10 | KAT2B | 0.119 | 0.392 | bioplex (MAGEA10) bioplex_WMM |
| MAGEA10 | CRTC3 | 0.103 | 0.366 | bioplex (MAGEA10) bioplex_WMM |
| MAGEA10 | QSER1 | 0.046 | 0.293 | hein_WMM bioplex (MAGEA10) bioplex_WMM hein (MAGEA10) |
| KAT2A | KAT2B | 0.031 | 0.24 | bioplex_WMM WMM_only |
| FAM216A | FOXJ2 | 0.011 | 0.152 | hein_WMM bioplex_WMM WMM_only |
| FAM216A | NCOA2 | 0.011 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| FOXJ2 | NCOA2 | 0.011 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| FAM216A | ERI1 | 0.01 | 0.105 | bioplex_WMM WMM_only |
| FOXJ2 | ERI1 | 0.01 | 0.105 | bioplex_WMM WMM_only |
| NCOA2 | QSER1 | 0.009 | 0.108 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NCOA2 | ERI1 | 0.009 | 0.111 | bioplex_WMM WMM_only |
| FOXJ2 | QSER1 | 0.009 | 0.113 | hein_WMM bioplex_WMM WMM_only |
| FAM216A | QSER1 | 0.009 | 0.113 | hein_WMM bioplex_WMM WMM_only |
| KAT2A | FAM216A | 0.009 | 0.114 | hein_WMM bioplex_WMM WMM_only |
| KAT2A | FOXJ2 | 0.009 | 0.114 | hein_WMM bioplex_WMM WMM_only |
| CRTC3 | ERI1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| FAM216A | CRTC3 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| FOXJ2 | CRTC3 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| NCOA2 | CRTC3 | 0.009 | 0.105 | bioplex_WMM youn_WMM WMM_only |
| MAGEA9 | FAM216A | 0.009 | 0.092 | bioplex_WMM WMM_only |
| MAGEA9 | FOXJ2 | 0.009 | 0.092 | bioplex_WMM WMM_only |
| MAGEA9 | ERI1 | 0.009 | 0.092 | bioplex_WMM WMM_only |
| KAT2A | NCOA2 | 0.009 | 0.095 | hein_WMM bioplex_WMM WMM_only |
| MAGEA9 | NCOA2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| ERI1 | QSER1 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| MAGEA9 | CRTC3 | 0.008 | 0.089 | bioplex_WMM WMM_only |
| FAM216A | KAT2B | 0.008 | 0.085 | bioplex_WMM WMM_only |
| KAT2B | ERI1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| FOXJ2 | KAT2B | 0.008 | 0.085 | bioplex_WMM WMM_only |
| KAT2A | ERI1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CRTC3 | QSER1 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| NCOA2 | KAT2B | 0.008 | 0.081 | bioplex_WMM WMM_only |
| MAGEA9 | QSER1 | 0.008 | 0.071 | bioplex_WMM WMM_only |
| KAT2B | CRTC3 | 0.008 | 0.058 | bioplex_WMM WMM_only |
| KAT2A | CRTC3 | 0.008 | 0.057 | bioplex_WMM WMM_only |
| KAT2A | QSER1 | 0.008 | 0.025 | hein_WMM bioplex_WMM WMM_only |
| MAGEA9 | KAT2B | 0.008 | 0.025 | bioplex_WMM WMM_only |
| MAGEA9 | KAT2A | 0.008 | 0.025 | bioplex_WMM WMM_only |
| KAT2B | QSER1 | 0.008 | 0.011 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02380 has an average edge precision of 0.214 which is ranked 5968 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAGEA9 | HuMAP2_00552 HuMAP2_02380 HuMAP2_03339 HuMAP2_06614 |
| NCOA2 | HuMAP2_01041 HuMAP2_01888 HuMAP2_02380 HuMAP2_03339 |
| KAT2A | HuMAP2_01041 HuMAP2_02144 HuMAP2_02380 HuMAP2_02884 HuMAP2_04385 HuMAP2_06559 HuMAP2_06947 |
| ERI1 | HuMAP2_02380 |
| CRTC3 | HuMAP2_02380 |
| FAM216A | HuMAP2_01041 HuMAP2_02380 HuMAP2_03339 |
| MAGEA10 | HuMAP2_00552 HuMAP2_01041 HuMAP2_01888 HuMAP2_02380 HuMAP2_03339 |
| KAT2B | HuMAP2_02144 HuMAP2_02380 HuMAP2_04385 HuMAP2_06559 HuMAP2_06947 |
| FOXJ2 | HuMAP2_01041 HuMAP2_01888 HuMAP2_02380 HuMAP2_03339 |
| QSER1 | HuMAP2_02380 HuMAP2_06842 |