hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02405
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDHA2 | Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II) | UniProt NCBI |
| PDK1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | UniProt NCBI |
| PDK3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204174 | 2.51774270163e-07 | 1.0 | PDK3 PDHA2 PDK1 | Regulation of pyruvate dehydrogenase (PDH) complex |
| REAC:R-HSA-70268 | 1.64282711281e-06 | 1.0 | PDK3 PDHA2 PDK1 | Pyruvate metabolism |
| REAC:R-HSA-5362517 | 4.44201748073e-06 | 1.0 | PDK3 PDHA2 PDK1 | Signaling by Retinoic Acid |
| REAC:R-HSA-71406 | 9.93609173322e-06 | 1.0 | PDK3 PDHA2 PDK1 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP4206 | 0.000182100906477 | 0.666666666667 | PDHA2 PDK1 | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| REAC:R-HSA-1428517 | 0.000330512177188 | 1.0 | PDK3 PDHA2 PDK1 | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05230 | 0.000987288198645 | 0.666666666667 | PDHA2 PDK1 | Central carbon metabolism in cancer |
| REAC:R-HSA-9006931 | 0.00107518583524 | 1.0 | PDK3 PDHA2 PDK1 | Signaling by Nuclear Receptors |
| KEGG:04066 | 0.00220707183162 | 0.666666666667 | PDHA2 PDK1 | HIF-1 signaling pathway |
| GO:0097411 | 0.00405722906526 | 0.666666666667 | PDK3 PDK1 | hypoxia-inducible factor-1alpha signaling pathway |
| GO:0004740 | 0.00811409485621 | 0.666666666667 | PDK3 PDK1 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| GO:0006090 | 0.0288576025313 | 1.0 | PDK3 PDHA2 PDK1 | pyruvate metabolic process |
| GO:0010510 | 0.0378589948753 | 0.666666666667 | PDK3 PDK1 | regulation of acetyl-CoA biosynthetic process from pyruvate |
| GO:0050812 | 0.0378589948753 | 0.666666666667 | PDK3 PDK1 | regulation of acyl-CoA biosynthetic process |
| WP:WP528 | 0.0499785733994 | 0.333333333333 | PDHA2 | Acetylcholine Synthesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PDHA2 | PDK3 | 1.0 | 0.949 | bioplex (PDK3) bioplex_WMM |
| PDK3 | PDK1 | 1.0 | 0.949 | hein_WMM bioplex (PDK1,PDK3) bioplex_WMM youn_WMM hein (PDK1) |
| PDHA2 | PDK1 | 0.008 | 0.027 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02405 has an average edge precision of 0.642 which is ranked 1712 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDHA2 | HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06120 HuMAP2_06177 |
| PDK1 | HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_03608 |
| PDK3 | HuMAP2_00749 HuMAP2_01188 HuMAP2_02405 HuMAP2_02908 HuMAP2_06086 |