hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02419
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDC73 | Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein) | UniProt NCBI |
| ELOA | Elongin-A (EloA) (Elongin 110 kDa subunit) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Transcription elongation factor B polypeptide 3) | UniProt NCBI |
| CTR9 | RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) | UniProt NCBI |
| LEO1 | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | UniProt NCBI |
| PAF1 | RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) | UniProt NCBI |
| WDR61 | WD repeat-containing protein 61 (Meiotic recombination REC14 protein homolog) (SKI8 homolog) (Ski8) [Cleaved into: WD repeat-containing protein 61, N-terminally processed] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1167 | 6.09820937128e-17 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | Paf complex |
| REAC:R-HSA-75955 | 4.87684378314e-13 | 1.0 | PAF1 CTR9 CDC73 LEO1 ELOA WDR61 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 4.87684378314e-13 | 1.0 | PAF1 CTR9 CDC73 LEO1 ELOA WDR61 | Formation of RNA Pol II elongation complex |
| GO:0016593 | 2.75202561382e-12 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | Cdc73/Paf1 complex |
| REAC:R-HSA-674695 | 3.79001374099e-12 | 1.0 | PAF1 CTR9 CDC73 LEO1 ELOA WDR61 | RNA Polymerase II Pre-transcription Events |
| GO:0032968 | 3.03945621632e-10 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | positive regulation of transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-8866654 | 6.13816459257e-10 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | E3 ubiquitin ligases ubiquitinate target proteins |
| GO:0006368 | 9.17610429398e-10 | 1.0 | PAF1 CTR9 CDC73 LEO1 ELOA WDR61 | transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-8852135 | 2.77049977827e-09 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | Protein ubiquitination |
| GO:0034243 | 3.96312010577e-09 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | regulation of transcription elongation from RNA polymerase II promoter |
| GO:0006354 | 5.3127668221e-09 | 1.0 | PAF1 CTR9 CDC73 LEO1 ELOA WDR61 | DNA-templated transcription, elongation |
| GO:0032786 | 5.82915372209e-09 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | positive regulation of DNA-templated transcription, elongation |
| GO:0001711 | 4.60828413382e-08 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | endodermal cell fate commitment |
| GO:0032784 | 6.72200990848e-08 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | regulation of DNA-templated transcription, elongation |
| GO:0045638 | 9.34955208324e-08 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | negative regulation of myeloid cell differentiation |
| GO:0008023 | 1.03878083327e-07 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | transcription elongation factor complex |
| GO:0033523 | 1.80981361376e-07 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | histone H2B ubiquitination |
| GO:0060795 | 6.65140313081e-07 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | cell fate commitment involved in formation of primary germ layer |
| GO:0016591 | 6.85127440347e-07 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | RNA polymerase II, holoenzyme |
| GO:1903707 | 1.3353372641e-06 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | negative regulation of hemopoiesis |
| WP:WP2853 | 2.800656837e-06 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | Endoderm Differentiation |
| GO:0055029 | 2.98904170003e-06 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 3.15131232749e-06 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | DNA-directed RNA polymerase complex |
| GO:0030880 | 3.68082360643e-06 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | RNA polymerase complex |
| GO:0031440 | 5.45777947309e-06 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | regulation of mRNA 3'-end processing |
| GO:0010390 | 8.66795236882e-06 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | histone monoubiquitination |
| GO:0035987 | 2.14812534311e-05 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | endodermal cell differentiation |
| GO:0000993 | 2.40824494048e-05 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | RNA polymerase II complex binding |
| GO:0001706 | 2.69127816091e-05 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | endoderm formation |
| GO:0045637 | 3.18810892015e-05 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | regulation of myeloid cell differentiation |
| GO:0006378 | 3.33134134934e-05 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | mRNA polyadenylation |
| REAC:R-HSA-73857 | 3.48623271686e-05 | 1.0 | PAF1 CTR9 CDC73 LEO1 ELOA WDR61 | RNA Polymerase II Transcription |
| GO:0007492 | 4.07918542432e-05 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | endoderm development |
| GO:0043631 | 4.07918542432e-05 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | RNA polyadenylation |
| GO:0043175 | 4.49707918505e-05 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | RNA polymerase core enzyme binding |
| GO:0016574 | 4.49707918505e-05 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | histone ubiquitination |
| REAC:R-HSA-74160 | 6.720667947e-05 | 1.0 | PAF1 CTR9 CDC73 LEO1 ELOA WDR61 | Gene expression (Transcription) |
| GO:0001098 | 9.85570254489e-05 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | basal transcription machinery binding |
| GO:0001099 | 9.85570254489e-05 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | basal RNA polymerase II transcription machinery binding |
| GO:0070063 | 0.000143725346999 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | RNA polymerase binding |
| GO:0006513 | 0.000165563014397 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | protein monoubiquitination |
| GO:0001704 | 0.000189796378442 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | formation of primary germ layer |
| GO:0061695 | 0.000213275731053 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | transferase complex, transferring phosphorus-containing groups |
| GO:0031442 | 0.000217734118711 | 0.5 | CDC73 LEO1 PAF1 | positive regulation of mRNA 3'-end processing |
| GO:0030099 | 0.000260256231992 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | myeloid cell differentiation |
| GO:0002683 | 0.000356638145596 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | negative regulation of immune system process |
| GO:0007369 | 0.000807281467413 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | gastrulation |
| GO:1903706 | 0.000915395559194 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | regulation of hemopoiesis |
| GO:0031124 | 0.001058235898 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | mRNA 3'-end processing |
| GO:0016570 | 0.00141416171115 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | histone modification |
| GO:0016569 | 0.00177296577542 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | covalent chromatin modification |
| GO:0045596 | 0.00236068657071 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | negative regulation of cell differentiation |
| GO:0045165 | 0.00249974066558 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | cell fate commitment |
| GO:0035327 | 0.00278918949629 | 0.5 | PAF1 WDR61 CTR9 | transcriptionally active chromatin |
| GO:0050684 | 0.00306979744334 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | regulation of mRNA processing |
| REAC:R-HSA-597592 | 0.00391856777133 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | Post-translational protein modification |
| GO:0050685 | 0.00416378298645 | 0.5 | CDC73 LEO1 PAF1 | positive regulation of mRNA processing |
| GO:0031123 | 0.00463345801571 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | RNA 3'-end processing |
| GO:2001162 | 0.00676235117068 | 0.333333333333 | WDR61 CTR9 | positive regulation of histone H3-K79 methylation |
| GO:2001160 | 0.00676235117068 | 0.333333333333 | WDR61 CTR9 | regulation of histone H3-K79 methylation |
| GO:0031062 | 0.00734442516369 | 0.5 | PAF1 WDR61 CTR9 | positive regulation of histone methylation |
| GO:0030097 | 0.0103700256678 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | hemopoiesis |
| GO:0048534 | 0.0117187153774 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | hematopoietic or lymphoid organ development |
| GO:0051093 | 0.0123203537618 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | negative regulation of developmental process |
| GO:0002520 | 0.0160093787736 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | immune system development |
| GO:0034729 | 0.020283420769 | 0.333333333333 | WDR61 CTR9 | histone H3-K79 methylation |
| GO:0031060 | 0.0222806450818 | 0.5 | PAF1 WDR61 CTR9 | regulation of histone methylation |
| GO:0016567 | 0.0232452530705 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | protein ubiquitination |
| REAC:R-HSA-392499 | 0.0232605972232 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | Metabolism of proteins |
| GO:0006325 | 0.0260155392968 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | chromatin organization |
| GO:0006357 | 0.0329980810507 | 1.0 | PAF1 CTR9 CDC73 LEO1 ELOA WDR61 | regulation of transcription by RNA polymerase II |
| GO:0032446 | 0.0424115510531 | 0.833333333333 | CDC73 CTR9 LEO1 WDR61 PAF1 | protein modification by small protein conjugation |
| GO:0048598 | 0.0457293961323 | 0.666666666667 | CDC73 LEO1 CTR9 PAF1 | embryonic morphogenesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PAF1 | CDC73 | 1.0 | 0.949 | hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73) Malo fraction boldt_WMM |
| PAF1 | CTR9 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CTR9) Malo fraction boldt_WMM |
| LEO1 | CDC73 | 1.0 | 0.949 | hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73,LEO1) Malo fraction boldt_WMM |
| CDC73 | WDR61 | 1.0 | 0.949 | hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73,WDR61) Malo fraction boldt_WMM |
| CDC73 | CTR9 | 1.0 | 0.949 | hein_WMM bioplex (CDC73) bioplex_WMM Guru boldt youn_WMM hein (CDC73,CTR9) Malo fraction boldt_WMM |
| LEO1 | CTR9 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CTR9,LEO1) Malo fraction boldt_WMM |
| PAF1 | WDR61 | 0.999 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (WDR61) Malo fraction boldt_WMM |
| LEO1 | PAF1 | 0.998 | 0.945 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (LEO1) Malo fraction boldt_WMM |
| LEO1 | WDR61 | 0.997 | 0.929 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (LEO1,WDR61) Malo fraction boldt_WMM |
| WDR61 | CTR9 | 0.988 | 0.901 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CTR9) Malo fraction boldt_WMM |
| ELOA | CTR9 | 0.1 | 0.362 | hein_WMM boldt youn_WMM hein (CTR9) boldt_WMM |
| LEO1 | ELOA | 0.041 | 0.271 | hein_WMM boldt youn_WMM hein (LEO1) boldt_WMM |
| CDC73 | ELOA | 0.01 | 0.097 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PAF1 | ELOA | 0.009 | 0.098 | hein_WMM boldt youn_WMM boldt_WMM |
| WDR61 | ELOA | 0.008 | 0.084 | hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM |
Images
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Complex HuMAP2_02419 has an average edge precision of 0.689 which is ranked 1422 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDC73 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_03117 |
| ELOA | HuMAP2_00070 HuMAP2_02419 HuMAP2_04183 HuMAP2_05769 |
| CTR9 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_06434 |
| LEO1 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_03117 |
| PAF1 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 HuMAP2_06434 |
| WDR61 | HuMAP2_00070 HuMAP2_01728 HuMAP2_02419 |