hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02424
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMN1 | Survival motor neuron protein (Component of gems 1) (Gemin-1) | UniProt NCBI |
| SMN1 | Survival motor neuron protein (Component of gems 1) (Gemin-1) | UniProt NCBI |
| DDX20 | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | UniProt NCBI |
| GEMIN2 | Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) | UniProt NCBI |
| GEMIN8 | Gem-associated protein 8 (Gemin-8) (Protein FAM51A1) | UniProt NCBI |
| GEMIN7 | Gem-associated protein 7 (Gemin-7) (SIP3) | UniProt NCBI |
| GEMIN6 | Gem-associated protein 6 (Gemin-6) (SIP2) | UniProt NCBI |
| GEMIN4 | Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97) | UniProt NCBI |
| LSM11 | U7 snRNA-associated Sm-like protein LSm11 | UniProt NCBI |
| GEMIN5 | Gem-associated protein 5 (Gemin5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1143 | 7.39509995372e-20 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | SMN complex |
| CORUM:1752 | 8.55866679422e-20 | 0.75 | GEMIN5 GEMIN2 GEMIN4 GEMIN7 GEMIN6 DDX20 | SMN complex |
| GO:0032797 | 4.09671104818e-18 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | SMN complex |
| CORUM:1751 | 7.18679681407e-18 | 0.75 | GEMIN5 GEMIN2 GEMIN4 GEMIN7 GEMIN6 DDX20 | SMN complex |
| GO:0034719 | 2.41347674848e-16 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | SMN-Sm protein complex |
| CORUM:1745 | 4.27917462687e-16 | 0.75 | GEMIN5 GEMIN2 GEMIN4 GEMIN7 GEMIN6 DDX20 | SMN complex |
| REAC:R-HSA-191859 | 4.38705473757e-15 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | snRNP Assembly |
| REAC:R-HSA-194441 | 4.38705473757e-15 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | Metabolism of non-coding RNA |
| GO:0120114 | 1.25710649186e-14 | 1.0 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 LSM11 DDX20 | Sm-like protein family complex |
| GO:0000387 | 1.56422651114e-13 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | spliceosomal snRNP assembly |
| CORUM:3284 | 1.58119379133e-12 | 0.5 | GEMIN5 GEMIN2 GEMIN4 DDX20 | SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN) |
| KEGG:03013 | 4.01037771643e-12 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | RNA transport |
| GO:0051170 | 6.91000797758e-10 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | import into nucleus |
| REAC:R-HSA-8953854 | 2.29458867922e-09 | 1.0 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 LSM11 DDX20 | Metabolism of RNA |
| CORUM:3296 | 4.70911134935e-09 | 0.375 | GEMIN5 GEMIN4 DDX20 | SMN complex (GEMIN5,4,3), SMN-independent intermediate |
| GO:0006397 | 1.21342588457e-08 | 1.0 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 LSM11 DDX20 | mRNA processing |
| CORUM:824 | 1.8831701816e-08 | 0.375 | GEMIN2 GEMIN4 DDX20 | Anti-SMN protein complex |
| GO:0022618 | 2.4292905145e-08 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | ribonucleoprotein complex assembly |
| GO:0071826 | 3.96305879143e-08 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | ribonucleoprotein complex subunit organization |
| CORUM:832 | 9.41110885571e-08 | 0.375 | GEMIN2 GEMIN4 DDX20 | Anti-Sm protein complex |
| GO:0006913 | 2.22594050537e-07 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | nucleocytoplasmic transport |
| GO:0051169 | 2.40802029183e-07 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | nuclear transport |
| CORUM:1749 | 5.64097851901e-07 | 0.375 | GEMIN2 GEMIN4 DDX20 | SMN-PolII-RHA complex |
| GO:0000398 | 6.5070260524e-07 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | mRNA splicing, via spliceosome |
| GO:0000377 | 6.5070260524e-07 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 6.96111138858e-07 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | RNA splicing, via transesterification reactions |
| GO:0016071 | 1.32830215932e-06 | 1.0 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 LSM11 DDX20 | mRNA metabolic process |
| GO:0022613 | 2.1619418741e-06 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | ribonucleoprotein complex biogenesis |
| GO:0008380 | 2.1619418741e-06 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | RNA splicing |
| GO:0006396 | 2.51669931039e-06 | 1.0 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 LSM11 DDX20 | RNA processing |
| CORUM:3298 | 1.16880143691e-05 | 0.25 | GEMIN2 GEMIN5 | SMN complex (GEMIN2,5, SMN) |
| CORUM:3297 | 3.50546248845e-05 | 0.25 | GEMIN7 GEMIN6 | SMN complex (GEMIN6,7, UNRIP), SMN-independent intermediate |
| CORUM:1750 | 7.00904180673e-05 | 0.25 | GEMIN4 DDX20 | PPP4C-PPP4R2-Gemin3-Gemin4 complex |
| CORUM:1746 | 0.000245118829946 | 0.25 | GEMIN2 GEMIN4 | SMN containing complex |
| GO:0097504 | 0.00028444859377 | 0.375 | GEMIN2 GEMIN7 GEMIN6 | Gemini of coiled bodies |
| CORUM:0000000 | 0.000356401437906 | 1.0 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 LSM11 DDX20 | CORUM root |
| CORUM:1142 | 0.000419977984057 | 0.25 | GEMIN2 DDX20 | SMN complex |
| GO:0034622 | 0.000720385892789 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | cellular protein-containing complex assembly |
| GO:0016604 | 0.00583833513213 | 0.75 | GEMIN5 GEMIN2 GEMIN4 GEMIN6 LSM11 GEMIN7 | nuclear body |
| GO:0065003 | 0.020012843186 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | protein-containing complex assembly |
| GO:0046907 | 0.0266810279817 | 0.875 | GEMIN5 GEMIN2 GEMIN8 GEMIN7 GEMIN4 GEMIN6 DDX20 | intracellular transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DDX20 | GEMIN5 | 0.998 | 0.936 | hein_WMM youn (DDX20) bioplex (DDX20) bioplex_WMM youn_WMM hein (GEMIN5) gupta_WMM treiber_WMM |
| GEMIN4 | DDX20 | 0.997 | 0.93 | hein_WMM youn (DDX20) bioplex (DDX20) bioplex_WMM youn_WMM treiber_WMM |
| DDX20 | GEMIN7 | 0.99 | 0.909 | hein_WMM youn (DDX20) bioplex (DDX20) bioplex_WMM youn_WMM hein (GEMIN7) |
| GEMIN7 | GEMIN8 | 0.968 | 0.88 | hein_WMM bioplex (GEMIN8) bioplex_WMM youn_WMM hein (GEMIN7) |
| GEMIN8 | GEMIN6 | 0.883 | 0.818 | hein_WMM bioplex (GEMIN6,GEMIN8) bioplex_WMM youn_WMM |
| SMN1 | GEMIN6 | 0.834 | 0.78 | hein_WMM bioplex (SMN1) bioplex_WMM youn_WMM hein (SMN1) |
| SMN1 | DDX20 | 0.797 | 0.764 | hein_WMM youn (DDX20) bioplex_WMM youn_WMM hein (SMN1) gupta_WMM treiber_WMM |
| DDX20 | GEMIN8 | 0.683 | 0.711 | hein_WMM youn (DDX20) bioplex (DDX20,GEMIN8) bioplex_WMM youn_WMM |
| DDX20 | GEMIN6 | 0.598 | 0.668 | hein_WMM youn (DDX20) bioplex (DDX20,GEMIN6) bioplex_WMM youn_WMM |
| GEMIN2 | DDX20 | 0.536 | 0.641 | hein_WMM youn (DDX20) bioplex (DDX20,GEMIN2) bioplex_WMM youn_WMM |
| GEMIN2 | GEMIN8 | 0.355 | 0.54 | hein_WMM bioplex (GEMIN8) bioplex_WMM youn_WMM treiber_WMM |
| GEMIN2 | GEMIN6 | 0.226 | 0.467 | hein_WMM bioplex (GEMIN6) bioplex_WMM youn_WMM |
| GEMIN4 | GEMIN6 | 0.127 | 0.4 | hein_WMM bioplex (GEMIN6) bioplex_WMM youn_WMM |
| GEMIN2 | GEMIN7 | 0.121 | 0.393 | hein_WMM bioplex (GEMIN2) bioplex_WMM youn_WMM hein (GEMIN7) |
| GEMIN4 | GEMIN8 | 0.114 | 0.384 | hein_WMM bioplex (GEMIN8) bioplex_WMM youn_WMM |
| GEMIN4 | GEMIN2 | 0.109 | 0.375 | hein_WMM bioplex (GEMIN2) bioplex_WMM youn_WMM |
| GEMIN2 | GEMIN5 | 0.09 | 0.355 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN5) |
| GEMIN8 | GEMIN5 | 0.087 | 0.352 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN5) |
| SMN1 | GEMIN7 | 0.059 | 0.328 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN7,SMN1) |
| GEMIN6 | GEMIN5 | 0.058 | 0.323 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN5) |
| DDX20 | LSM11 | 0.057 | 0.321 | hein_WMM youn (DDX20) bioplex (DDX20) bioplex_WMM youn_WMM |
| LSM11 | GEMIN5 | 0.053 | 0.299 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN5) |
| DDX20 | SMN1 | 0.052 | 0.3 | bioplex (DDX20) bioplex_WMM |
| GEMIN6 | SMN1 | 0.051 | 0.296 | bioplex (GEMIN6) bioplex_WMM |
| SMN1 | GEMIN2 | 0.046 | 0.292 | hein_WMM bioplex_WMM youn_WMM hein (SMN1) treiber_WMM |
| GEMIN8 | SMN1 | 0.031 | 0.239 | bioplex (GEMIN8) bioplex_WMM |
| GEMIN7 | GEMIN6 | 0.029 | 0.232 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN7) |
| SMN1 | SMN1 | 0.029 | 0.23 | bioplex (SMN1) bioplex_WMM |
| GEMIN4 | GEMIN7 | 0.026 | 0.224 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN7) |
| SMN1 | GEMIN8 | 0.02 | 0.187 | hein_WMM bioplex_WMM youn_WMM hein (SMN1) treiber_WMM |
| GEMIN7 | GEMIN5 | 0.02 | 0.19 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN5,GEMIN7) |
| GEMIN8 | LSM11 | 0.018 | 0.177 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| GEMIN4 | GEMIN5 | 0.014 | 0.138 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN5) treiber_WMM |
| GEMIN6 | LSM11 | 0.013 | 0.147 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| GEMIN4 | SMN1 | 0.013 | 0.148 | hein_WMM bioplex_WMM youn_WMM hein (SMN1) gupta_WMM |
| GEMIN4 | LSM11 | 0.012 | 0.148 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| GEMIN2 | SMN1 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| GEMIN2 | LSM11 | 0.011 | 0.142 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SMN1 | LSM11 | 0.009 | 0.109 | hein_WMM youn_WMM hein (SMN1) |
| GEMIN4 | SMN1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| GEMIN7 | SMN1 | 0.009 | 0.105 | bioplex_WMM WMM_only |
| SMN1 | LSM11 | 0.009 | 0.091 | bioplex_WMM WMM_only |
| SMN1 | GEMIN5 | 0.008 | 0.068 | bioplex_WMM WMM_only |
| GEMIN7 | LSM11 | 0.005 | 0.013 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN7) |
| SMN1 | GEMIN5 | 0.005 | 0.011 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN5,SMN1) gupta_WMM |
Images
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Complex HuMAP2_02424 has an average edge precision of 0.362 which is ranked 3724 out of all 6965 complexes.
Related Complexes