hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02425
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GBA | Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.104) (D-glucosyl-N-acylsphingosine glucohydrolase) (Imiglucerase) | UniProt NCBI |
| GPX4 | Phospholipid hydroperoxide glutathione peroxidase (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) | UniProt NCBI |
| GALE | UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:01100 | 0.0105851300972 | 1.0 | GPX4 GALE GBA | Metabolic pathways |
| REAC:R-HSA-5609977 | 0.0498572752401 | 0.333333333333 | GALE | Defective GALE can cause Epimerase-deficiency galactosemia (EDG) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GALE | GPX4 | 0.124 | 0.395 | bioplex (GALE) bioplex_WMM Guru fraction |
| GPX4 | GBA | 0.081 | 0.351 | bioplex_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_02425 has an average edge precision of 0.373 which is ranked 3603 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GBA | HuMAP2_02425 HuMAP2_02471 HuMAP2_03443 HuMAP2_04766 HuMAP2_06484 |
| GPX4 | HuMAP2_02425 HuMAP2_02733 HuMAP2_03443 HuMAP2_06776 |
| GALE | HuMAP2_00199 HuMAP2_02425 HuMAP2_02775 HuMAP2_03443 HuMAP2_06565 |