hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02439
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLR1C | DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40) | UniProt NCBI |
| POLR1A | DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) | UniProt NCBI |
| POLR1B | DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03020 | 1.22093847236e-07 | 1.0 | POLR1A POLR1B POLR1C | RNA polymerase |
| REAC:R-HSA-73863 | 2.02093811497e-06 | 1.0 | POLR1A POLR1B POLR1C | RNA Polymerase I Transcription Termination |
| WP:WP4022 | 5.09350508747e-06 | 1.0 | POLR1A POLR1B POLR1C | Pyrimidine metabolism |
| REAC:R-HSA-73762 | 7.29021391195e-06 | 1.0 | POLR1A POLR1B POLR1C | RNA Polymerase I Transcription Initiation |
| GO:0001054 | 2.59741127426e-05 | 1.0 | POLR1A POLR1B POLR1C | RNA polymerase I activity |
| GO:0005736 | 2.59741127426e-05 | 1.0 | POLR1A POLR1B POLR1C | RNA polymerase I complex |
| REAC:R-HSA-5250924 | 5.10580236014e-05 | 1.0 | POLR1A POLR1B POLR1C | B-WICH complex positively regulates rRNA expression |
| REAC:R-HSA-73772 | 5.28186451049e-05 | 1.0 | POLR1A POLR1B POLR1C | RNA Polymerase I Promoter Escape |
| REAC:R-HSA-5250913 | 8.18733958818e-05 | 1.0 | POLR1A POLR1B POLR1C | Positive epigenetic regulation of rRNA expression |
| REAC:R-HSA-427413 | 8.42814369371e-05 | 1.0 | POLR1A POLR1B POLR1C | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-5250941 | 9.17879069632e-05 | 1.0 | POLR1A POLR1B POLR1C | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 9.4385677915e-05 | 1.0 | POLR1A POLR1B POLR1C | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 9.70320053332e-05 | 1.0 | POLR1A POLR1B POLR1C | RNA Polymerase I Transcription |
| REAC:R-HSA-212165 | 0.000228431198544 | 1.0 | POLR1A POLR1B POLR1C | Epigenetic regulation of gene expression |
| GO:0006362 | 0.000331851076788 | 1.0 | POLR1A POLR1B POLR1C | transcription elongation from RNA polymerase I promoter |
| GO:0006363 | 0.000408229499224 | 1.0 | POLR1A POLR1B POLR1C | termination of RNA polymerase I transcription |
| GO:0006361 | 0.000450460137075 | 1.0 | POLR1A POLR1B POLR1C | transcription initiation from RNA polymerase I promoter |
| GO:0003899 | 0.0007056603357 | 1.0 | POLR1A POLR1B POLR1C | DNA-directed 5'-3' RNA polymerase activity |
| WP:WP405 | 0.000785169744646 | 0.666666666667 | POLR1A POLR1B | Eukaryotic Transcription Initiation |
| GO:0097747 | 0.000897287531108 | 1.0 | POLR1A POLR1B POLR1C | RNA polymerase activity |
| GO:0034062 | 0.000897287531108 | 1.0 | POLR1A POLR1B POLR1C | 5'-3' RNA polymerase activity |
| CORUM:5233 | 0.000925345287905 | 0.666666666667 | POLR1A POLR1B | TNF-alpha/NF-kappa B signaling complex 5 |
| GO:0006360 | 0.00295242108794 | 1.0 | POLR1A POLR1B POLR1C | transcription by RNA polymerase I |
| GO:0045815 | 0.00295242108794 | 1.0 | POLR1A POLR1B POLR1C | positive regulation of gene expression, epigenetic |
| GO:0006353 | 0.00564855215433 | 1.0 | POLR1A POLR1B POLR1C | DNA-templated transcription, termination |
| GO:0055029 | 0.0129761581422 | 1.0 | POLR1A POLR1B POLR1C | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 0.0133902908488 | 1.0 | POLR1A POLR1B POLR1C | DNA-directed RNA polymerase complex |
| GO:0030880 | 0.0146853637429 | 1.0 | POLR1A POLR1B POLR1C | RNA polymerase complex |
| GO:0006354 | 0.0170248502613 | 1.0 | POLR1A POLR1B POLR1C | DNA-templated transcription, elongation |
| GO:0016779 | 0.0201449224406 | 1.0 | POLR1A POLR1B POLR1C | nucleotidyltransferase activity |
| HP:0000453 | 0.0376620740847 | 0.666666666667 | POLR1A POLR1C | Choanal atresia |
| HP:0008551 | 0.0393048254184 | 0.666666666667 | POLR1A POLR1C | Microtia |
| HP:0000415 | 0.041834410056 | 0.666666666667 | POLR1A POLR1C | Abnormality of the choanae |
| HP:0008772 | 0.0426950555564 | 0.666666666667 | POLR1A POLR1C | Aplasia/Hypoplasia of the external ear |
| HP:0000327 | 0.0426950555564 | 0.666666666667 | POLR1A POLR1C | Hypoplasia of the maxilla |
| HP:0008771 | 0.0462248590062 | 0.666666666667 | POLR1A POLR1C | Aplasia/Hypoplasia of the ear |
| CORUM:1558 | 0.0499776345577 | 0.333333333333 | POLR1B | POLR1B-RRN3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLR1A | POLR1B | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (POLR1A) Malo fraction treiber_WMM |
| POLR1C | POLR1A | 1.0 | 0.949 | hein_WMM bioplex (POLR1C) bioplex_WMM hein (POLR1A) Malo fraction |
| POLR1C | POLR1B | 1.0 | 0.949 | hein_WMM bioplex (POLR1C) bioplex_WMM boldt Malo fraction boldt_WMM |
Images
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Complex HuMAP2_02439 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| POLR1C | HuMAP2_00232 HuMAP2_02024 HuMAP2_02071 HuMAP2_02439 HuMAP2_02562 HuMAP2_04738 |
| POLR1A | HuMAP2_00232 HuMAP2_00839 HuMAP2_01570 HuMAP2_02439 HuMAP2_02562 HuMAP2_04738 HuMAP2_04981 |
| POLR1B | HuMAP2_00232 HuMAP2_00839 HuMAP2_01570 HuMAP2_02439 HuMAP2_02562 HuMAP2_04738 |