hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02446
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TMX2 | Thioredoxin-related transmembrane protein 2 (Cell proliferation-inducing gene 26 protein) (Thioredoxin domain-containing protein 14) | UniProt NCBI |
| THEM6 | Protein THEM6 (Mesenchymal stem cell protein DSCD75) (Thioesterase superfamily member 6) | UniProt NCBI |
| ARL8B | ADP-ribosylation factor-like protein 8B (ADP-ribosylation factor-like protein 10C) (Novel small G protein indispensable for equal chromosome segregation 1) | UniProt NCBI |
| SRPRA | Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) | UniProt NCBI |
| SRPRB | Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03060 | 0.0010832092153 | 0.4 | SRPRB SRPRA | Protein export |
| REAC:R-HSA-381038 | 0.0126969553517 | 0.4 | SRPRB SRPRA | XBP1(S) activates chaperone genes |
| REAC:R-HSA-381070 | 0.0138877528683 | 0.4 | SRPRB SRPRA | IRE1alpha activates chaperones |
| REAC:R-HSA-381119 | 0.0454350363854 | 0.4 | SRPRB SRPRA | Unfolded Protein Response (UPR) |
| MIRNA:hsa-miR-1251-3p | 0.0482780268961 | 0.4 | ARL8B SRPRA | hsa-miR-1251-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SRPRB | SRPRA | 1.0 | 0.949 | hein_WMM bioplex (SRPRA,SRPRB) bioplex_WMM Guru boldt youn_WMM hein (SRPRA) gupta_WMM fraction boldt_WMM |
| THEM6 | SRPRB | 0.058 | 0.326 | bioplex (SRPRB) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SRPRB | ARL8B | 0.023 | 0.208 | bioplex (SRPRB) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| SRPRB | TMX2 | 0.022 | 0.207 | bioplex (SRPRB) bioplex_WMM |
| THEM6 | SRPRA | 0.007 | 0.006 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TMX2 | ARL8B | 0.006 | 0.004 | bioplex_WMM WMM_only |
| SRPRA | ARL8B | 0.006 | 0.008 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SRPRA | TMX2 | 0.005 | 0.011 | bioplex_WMM WMM_only |
| THEM6 | ARL8B | 0.005 | 0.013 | bioplex_WMM youn_WMM WMM_only |
| THEM6 | TMX2 | 0.004 | 0.011 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02446 has an average edge precision of 0.174 which is ranked 6484 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TMX2 | HuMAP2_02446 |
| THEM6 | HuMAP2_01699 HuMAP2_02446 |
| ARL8B | HuMAP2_02446 |
| SRPRA | HuMAP2_01699 HuMAP2_02248 HuMAP2_02446 HuMAP2_05917 HuMAP2_06129 |
| SRPRB | HuMAP2_01699 HuMAP2_02446 HuMAP2_05917 |