hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02449
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CAPNS1 | Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) | UniProt NCBI |
| CD99L2 | CD99 antigen-like protein 2 (MIC2-like protein 1) (CD antigen CD99) | UniProt NCBI |
| CAPN1 | Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6710 | 3.35600554376e-06 | 0.666666666667 | CAPNS1 CAPN1 | Calpain 1 |
| REAC:R-HSA-8862803 | 0.00140483748394 | 0.666666666667 | CAPNS1 CAPN1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00140483748394 | 0.666666666667 | CAPNS1 CAPN1 | Neurodegenerative Diseases |
| WP:WP185 | 0.00408673569856 | 0.666666666667 | CAPNS1 CAPN1 | Integrin-mediated Cell Adhesion |
| TF:M05797 | 0.0283955176165 | 0.666666666667 | CD99L2 CAPN1 | Factor: ZNF613; motif: NGGTTAAAAATA |
| TF:M05797_0 | 0.0283955176165 | 0.666666666667 | CD99L2 CAPN1 | Factor: ZNF613; motif: NGGTTAAAAATA; match class: 0 |
| REAC:R-HSA-6809371 | 0.0316864591018 | 0.666666666667 | CAPNS1 CAPN1 | Formation of the cornified envelope |
| CORUM:6706 | 0.0499776345577 | 0.333333333333 | CAPN1 | CAPN1-HSP90AB1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CD99L2 | CAPN1 | 0.997 | 0.93 | bioplex (CAPN1) bioplex_WMM |
| CAPNS1 | CAPN1 | 0.992 | 0.912 | hein_WMM bioplex (CAPN1) bioplex_WMM hein (CAPN1) |
| CAPNS1 | CD99L2 | 0.008 | 0.043 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02449 has an average edge precision of 0.628 which is ranked 1789 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CAPNS1 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 |
| CD99L2 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 |
| CAPN1 | HuMAP2_00660 HuMAP2_01189 HuMAP2_02449 HuMAP2_02830 HuMAP2_05795 |