hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02452
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAD51B | DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1) | UniProt NCBI |
| RAD51D | DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD) | UniProt NCBI |
| XRCC2 | DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:68 | 9.0142507219e-10 | 1.0 | XRCC2 RAD51B RAD51D | BCDX2 complex |
| CORUM:258 | 9.0142507219e-10 | 1.0 | XRCC2 RAD51B RAD51D | BCDX2 complex |
| CORUM:251 | 9.0142507219e-10 | 1.0 | XRCC2 RAD51B RAD51D | BCDX2 complex |
| CORUM:261 | 2.25356268047e-09 | 1.0 | XRCC2 RAD51B RAD51D | RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex |
| KEGG:03440 | 2.97115076526e-07 | 1.0 | XRCC2 RAD51B RAD51D | Homologous recombination |
| GO:0033063 | 3.63274304092e-07 | 1.0 | XRCC2 RAD51B RAD51D | Rad51B-Rad51C-Rad51D-XRCC2 complex |
| REAC:R-HSA-5693554 | 1.16895196861e-06 | 1.0 | XRCC2 RAD51B RAD51D | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| GO:0033061 | 1.81637152046e-06 | 1.0 | XRCC2 RAD51B RAD51D | DNA recombinase mediator complex |
| REAC:R-HSA-5693568 | 2.23000067859e-06 | 1.0 | XRCC2 RAD51B RAD51D | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 2.45300074645e-06 | 1.0 | XRCC2 RAD51B RAD51D | Resolution of D-Loop Structures |
| CORUM:262 | 3.35600554376e-06 | 0.666666666667 | XRCC2 RAD51D | RAD51L3-XRCC2 complex |
| REAC:R-HSA-5693616 | 3.79279954124e-06 | 1.0 | XRCC2 RAD51B RAD51D | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-5693579 | 4.79270307132e-06 | 1.0 | XRCC2 RAD51B RAD51D | Homologous DNA Pairing and Strand Exchange |
| CORUM:2228 | 1.00675659188e-05 | 0.666666666667 | XRCC2 RAD51D | BLM-RAD51L3-XRCC2 complex |
| REAC:R-HSA-5685942 | 1.96383930727e-05 | 1.0 | XRCC2 RAD51B RAD51D | HDR through Homologous Recombination (HRR) |
| GO:0000400 | 5.08584025729e-05 | 1.0 | XRCC2 RAD51B RAD51D | four-way junction DNA binding |
| REAC:R-HSA-5693567 | 0.000160847790881 | 1.0 | XRCC2 RAD51B RAD51D | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| GO:0000217 | 0.000183816797871 | 1.0 | XRCC2 RAD51B RAD51D | DNA secondary structure binding |
| REAC:R-HSA-5693538 | 0.000184352717389 | 1.0 | XRCC2 RAD51B RAD51D | Homology Directed Repair |
| REAC:R-HSA-5693532 | 0.000324502864875 | 1.0 | XRCC2 RAD51B RAD51D | DNA Double-Strand Break Repair |
| REAC:R-HSA-73894 | 0.00245537461814 | 1.0 | XRCC2 RAD51B RAD51D | DNA Repair |
| GO:0005657 | 0.00378386515143 | 1.0 | XRCC2 RAD51B RAD51D | replication fork |
| GO:0042148 | 0.0135228859698 | 0.666666666667 | XRCC2 RAD51D | strand invasion |
| GO:0000725 | 0.0268132763851 | 1.0 | XRCC2 RAD51B RAD51D | recombinational repair |
| GO:0000724 | 0.0268132763851 | 1.0 | XRCC2 RAD51B RAD51D | double-strand break repair via homologous recombination |
| GO:0051321 | 0.033252767518 | 1.0 | XRCC2 RAD51B RAD51D | meiotic cell cycle |
| CORUM:256 | 0.0499776345577 | 0.333333333333 | RAD51B | RAD51B-RAD51C complex |
| CORUM:260 | 0.0499776345577 | 0.333333333333 | RAD51B | RAD51B-RAD51C complex |
| CORUM:5683 | 0.0499776345577 | 0.333333333333 | XRCC2 | hRAD51C-hXRCC3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC2 | RAD51D | 0.758 | 0.747 | bioplex (XRCC2) bioplex_WMM |
| XRCC2 | RAD51B | 0.045 | 0.284 | bioplex (XRCC2) bioplex_WMM |
| RAD51B | RAD51D | 0.01 | 0.134 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_02452 has an average edge precision of 0.388 which is ranked 3443 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RAD51B | HuMAP2_02452 HuMAP2_03298 HuMAP2_03506 |
| RAD51D | HuMAP2_02452 HuMAP2_03298 HuMAP2_03506 HuMAP2_03862 |
| XRCC2 | HuMAP2_00467 HuMAP2_02452 HuMAP2_03298 HuMAP2_03506 HuMAP2_03862 |