hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02462
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATP2B4 | Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4) | UniProt NCBI |
| HSD17B6 | 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6) | UniProt NCBI |
| ATP2B1 | Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1) | UniProt NCBI |
| ATP2B3 | Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418359 | 2.22736463084e-07 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Reduction of cytosolic Ca++ levels |
| REAC:R-HSA-418360 | 3.10262114446e-06 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Platelet calcium homeostasis |
| KEGG:04978 | 4.07597108673e-06 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Mineral absorption |
| KEGG:04961 | 5.26171960509e-06 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Endocrine and other factor-regulated calcium reabsorption |
| KEGG:04970 | 1.7381246657e-05 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Salivary secretion |
| REAC:R-HSA-5578775 | 1.91225201676e-05 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Ion homeostasis |
| REAC:R-HSA-936837 | 2.1849215234e-05 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Ion transport by P-type ATPases |
| KEGG:04972 | 2.28687407492e-05 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Pancreatic secretion |
| KEGG:04925 | 2.94026709165e-05 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Aldosterone synthesis and secretion |
| GO:0005388 | 4.35775472874e-05 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | calcium transmembrane transporter activity, phosphorylative mechanism |
| KEGG:04261 | 9.34519130775e-05 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-418346 | 9.84181176004e-05 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Platelet homeostasis |
| KEGG:04022 | 0.000122203178829 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | cGMP-PKG signaling pathway |
| KEGG:04020 | 0.000175500256423 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Calcium signaling pathway |
| KEGG:04024 | 0.000214647688386 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | cAMP signaling pathway |
| REAC:R-HSA-5576891 | 0.00028199431919 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Cardiac conduction |
| REAC:R-HSA-983712 | 0.000897547675762 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Ion channel transport |
| REAC:R-HSA-397014 | 0.00111581489513 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Muscle contraction |
| GO:0015662 | 0.00147288799354 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | ion transmembrane transporter activity, phosphorylative mechanism |
| GO:1905056 | 0.00811409485621 | 0.5 | ATP2B1 ATP2B3 | calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration |
| GO:0030165 | 0.00848863295691 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | PDZ domain binding |
| GO:0019829 | 0.00898751047669 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | ATPase-coupled cation transmembrane transporter activity |
| GO:1903779 | 0.0106004966657 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | regulation of cardiac conduction |
| GO:0042625 | 0.0111781410126 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | ATPase-coupled ion transmembrane transporter activity |
| WP:WP536 | 0.0118694610121 | 0.5 | ATP2B1 ATP2B3 | Calcium Regulation in the Cardiac Cell |
| GO:1990034 | 0.0162267366884 | 0.5 | ATP2B1 ATP2B3 | calcium ion export across plasma membrane |
| REAC:R-HSA-109582 | 0.033540764945 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Hemostasis |
| GO:1901660 | 0.0405595771497 | 0.5 | ATP2B1 ATP2B3 | calcium ion export |
| REAC:R-HSA-382551 | 0.047385920536 | 0.75 | ATP2B4 ATP2B3 ATP2B1 | Transport of small molecules |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP2B3 | HSD17B6 | 0.379 | 0.549 | bioplex (HSD17B6) bioplex_WMM |
| ATP2B4 | HSD17B6 | 0.143 | 0.405 | bioplex (HSD17B6) bioplex_WMM |
| ATP2B1 | HSD17B6 | 0.055 | 0.309 | bioplex (HSD17B6) bioplex_WMM |
| ATP2B1 | ATP2B3 | 0.01 | 0.129 | bioplex_WMM gupta_WMM WMM_only |
| ATP2B4 | ATP2B1 | 0.009 | 0.112 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ATP2B4 | ATP2B3 | 0.008 | 0.032 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02462 has an average edge precision of 0.256 which is ranked 5283 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATP2B4 | HuMAP2_02462 HuMAP2_04031 HuMAP2_04174 |
| HSD17B6 | HuMAP2_02462 HuMAP2_04031 HuMAP2_04198 |
| ATP2B1 | HuMAP2_02462 HuMAP2_04031 HuMAP2_04198 |
| ATP2B3 | HuMAP2_02462 HuMAP2_04031 HuMAP2_04198 |